Sideroblastic anemias

Sideroblastic anemias: Excerpt from Professional Guide to Diseases (Eighth Edition)

Sideroblastic anemias are a group of heterogenous disorders with a common defect; they fail to use iron in hemoglobin (Hb) synthesis, despite the availability of adequate iron stores. These anemias may be hereditary or acquired; the acquired form, in turn, can be primary or secondary. Hereditary sideroblastic anemia commonly responds to treatment with pyridoxine. Correction of the secondary acquired form depends on the causative disorder; the primary acquired (idiopathic) form, however, resists treatment and usually proves fatal within 10 years after onset of complications or a concomitant disease.

Causes and incidence

Hereditary sideroblastic anemia appears to be transmitted by X-linked inheritance, occurring mostly in young males; females are carriers and usually show no signs of this disorder.

The acquired form may be secondary to ingestion of or exposure to toxins, such as alcohol and lead, or to certain drugs. It can also occur as a complication of other diseases, such as rheumatoid arthritis, lupus erythematosus, multiple myeloma, tuberculosis, and severe infections.

The primary acquired form, known as refractory anemia with ringed sideroblasts, is most common in elderly people. It’s commonly associated with thrombocytopenia or leukopenia as part of a myelodysplastic syndrome.

In sideroblastic anemia, normoblasts fail to use iron to synthesize Hb. As a result, iron is deposited in the mitochondria of normoblasts, which are then termed ringed sideroblasts.

Signs and symptoms

Sideroblastic anemias usually produce nonspecific clinical effects, which may exist for several years before being identified. Such effects include anorexia, fatigue, weakness, dizziness, pale skin and mucous membranes and, occasionally, enlarged lymph nodes. Heart and liver failure may develop due to excessive iron accumulation in these organs, causing dyspnea, exertional angina, slight jaundice, and hepatosplenomegaly. Hereditary sideroblastic anemia is associated with increased GI absorption of iron, causing signs of hemosiderosis. Additional symptoms in secondary sideroblastic anemia depend upon the underlying cause.

Diagnosis

Confirming diagnosis  Ringed sideroblasts on microscopic examination of bone marrow aspirate, stained with Prussian blue or alizarin red dye, confirm this diagnosis. (See Ringed sideroblast.)

Microscopic examination of blood shows erythrocytes to be hypochromic or normochromic and slightly macrocytic. Red cell precursors may be megaloblastic, with anisocytosis (abnormal variation in red blood cell [RBC] size) and poikilocytosis (abnormal variation in RBC shape). Unlike iron deficiency anemia, sideroblastic anemia lowers Hb levels and raises serum iron and transferrin levels. In turn, faulty Hb production raises urobilinogen and bilirubin levels. Platelets and leukocytes remain normal, but, occasionally, thrombocytopenia or leukopenia occurs.

Treatment

Treatment of sideroblastic anemias depends on the underlying cause. The hereditary form usually responds to several weeks of treatment with high doses of pyridoxine (vitamin B₆). The acquired secondary form generally subsides after the causative drug or toxin is removed, or the underlying condition is adequately treated. Folic acid supplements may also be beneficial when concomitant megaloblastic nuclear changes in RBC precursors are present. Elderly patients with sideroblastic anemia (usually the primary acquired form) are less likely to improve quickly and are more likely to develop serious complications. Deferoxamine may be used to treat chronic iron overload in selected patients.

Carefully crossmatched transfusions (providing needed Hb) or high doses of androgens are effective palliative measures for some patients with the primary acquired form of sideroblastic anemia. However, this form is essentially refractory to treatment and usually leads to death from acute leukemia or from respiratory or cardiac complications.

Some patients with sideroblastic anemia may benefit from phlebotomy to prevent hemochromatosis (the accumulation of iron in body tissues). Phlebotomy steps up the rate of erythropoiesis and uses up excess iron stores; thus, it reduces serum and total-body iron levels.

Special considerations

❑ Administer medications as ordered. Teach the patient the importance of continuing prescribed therapy, even after he begins to feel better.

❑ Provide frequent rest periods if the patient becomes easily fatigued.

❑ If phlebotomy is scheduled, explain the procedure thoroughly to help reduce anxiety. If this procedure must be repeated frequently, provide a high-protein diet to help replace the protein lost during phlebotomy. Encourage the patient to follow a similar diet at home.

❑ Always inquire about the possibility of exposure to lead in the home (especially for children) or on the job.

❑ Identify patients who abuse alcohol; refer them for appropriate therapy.

Pictures

Book Source Details

• Book Title: Professional Guide to Diseases (Eighth Edition)
• Author(s): Springhouse
• Year of Publication: 2005
• Copyright Details: Professional Guide to Diseases (Eighth Edition), Copyright © 2005 Lippincott Williams & Wilkins.

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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

More About This Book: Title: Professional Guide to Diseases (Eighth Edition) Authors: Springhouse Publisher: Lippincott Williams & Wilkins Copyright: 2005 ISBN: 1-58255-370-X

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