Clinical Trials for Irritable bowel syndrome

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Irritable bowel syndrome is grouped into the following categories:-

• View by trial name
• View by drugs used in Irritable bowel syndrome clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Irritable bowel syndrome:

• Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - MD-1100 Acetate
• A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c - This study is currently recruiting patients (Current: 23 Nov 2006) - DDP733
• Study Of Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy - This study has been completed (Current: 23 Nov 2006) - Alosetron
• Investigation of the Safety and Efficacy of Renzapride in Constipation Predominant Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Renzapride
• Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy - This study is no longer recruiting patients (Current: 23 Nov 2006) - alosetron
• An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - duloxetine
• Treatment of Functional Bowel Disorders - This study has been completed (Current: 23 Nov 2006) - Desipramine
• Acupuncture for Irritable Bowel Syndrome - This study has been completed (Current: 23 Nov 2006)
• Genetics of Fibromyalgia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study has been completed (Current: 23 Nov 2006)
• A Study of Crofelmer to Treat Diarrhea Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - crofelmer
• Eight-Weeks Of Treatment With Talnetant In Subjects With Irritable Bowel Syndrome (IBS) - This study has been completed (Current: 23 Nov 2006) - talnetant
• Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - dextromethorphan,naloxone,fentanyl,lidocaine
• Nursing Management of IBS: Improving Outcomes - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of YM060 in Diarrhea-Predominant Irritable Bowel Syndrome (d-IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - YM060
• Cerebral Resonance Magnetic Imaging During Rectal Distention - This study is currently recruiting patients (Current: 23 Nov 2006)
• DARWIN Study: A Randomization/Withdrawal Efficacy Study of Dexloxiglumide in C-IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - dexloxiglumide
• Study to Assess the Efficacy and Safety of Rifaximin Administered BID in the Treatment of Patients With Diarrhea-Associated Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - Rifaximin
• Effect of Butyrogenic Fibers in IBS Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Diet
• A Six-Month Study to Compare Outcome Differences and Visceral Response ... Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effect of Acupuncture on Symptoms of Diarrhea and Pain in IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Phase IIA Study of BMS-562086 in Patients With Irritable Bowel Syndrome - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - BMS-562086
• Phase 3 Study of YM060 in Patients With Diarrhea-Predominant Irritable Bowel Syndrome (d-IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - YM060
• Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lubiprostone
• Rifaximin for the Treatment of Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - Rifaximin
• The Effect of Probioticson Bloating in IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - Probiotic bacteria (Trevis R)
• A Study To Investigate GW427353 In Subjects With Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006) - GW427353,Placebo
• A Study To Investigate The Effect Of GW427353 On Gastrointestinal Transit In Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006) - Placebo,GW427353
• Pilot Study to Assess the Effects of AV608 on Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - AV608
• Brain Imaging and Pain in Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - placebo
• Acupuncture for Irritable Bowel Syndrome (IBS) - This study has been completed (Current: 23 Nov 2006)
• Efficacy of an Encapsulated Probiotic Bifidobacterium Infantis 35624 in Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - Bifidobacterium infantis 35624
• A Study To Investigate The Effect Of PD-217,014 On Abdominal Pain/Discomfort In Patients With IBS. - This study has been completed (Current: 23 Nov 2006) - PD-217,014
• Effect of Menstrual Cycle on CNS Processing of Gut Stimuli in IBS and Control - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
• 8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - DDP225
• Evaluation of Patient Education in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth. - This study is currently recruiting patients (Current: 23 Nov 2006) - Bacillus clausii
• Probiotics for Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lactobacillus plantarum MF 1298
• Efficacy of TMS in Chronic Idiopathic Pain Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Effects Of GW876008 On The Stomach In Patients With Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - GW876008
• Efficacy and Safety of DNK333 in Women With Diarrhea-Predominant Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - DNK333
• Study to Determine the Effectiveness of the Probiotic E. Coli Strain M17 in Treating Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006) - E. Coli Strain M17 Probiotic
• Study to Assess the Effect Of Alosetron On Mucosal Blood Flow - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - alosetron
• Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - GW876008
• Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lubiprostone
• The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Dose Ranging Study With the Probiotic Combination (VSL#3) in Diarrhea IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - VSL#3
• Development of Limited Contact CBT Treatment for IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Telomere Repair Gene Mutation in Inflammatory Bowel Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or No Fibre? - This study is currently recruiting patients (Current: 23 Nov 2006) - psyllium fibre (dietary supplement),wheat bran (dietary supplement),rice wheat (placebo)

Drugs used in Clinical Trials for Irritable bowel syndrome

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Irritable bowel syndrome:

• AV608 - Pilot Study to Assess the Effects of AV608 on Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Alosetron - Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Alosetron - Study Of Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy - This study has been completed (Current: 23 Nov 2006)
• Alosetron - Study to Assess the Effect Of Alosetron On Mucosal Blood Flow - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• BMS-562086 - A Phase IIA Study of BMS-562086 in Patients With Irritable Bowel Syndrome - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Bacillus clausii - EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bifidobacterium infantis 35624 - Efficacy of an Encapsulated Probiotic Bifidobacterium Infantis 35624 in Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Crofelmer - A Study of Crofelmer to Treat Diarrhea Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• DDP225 - 8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• DDP733 - A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c - This study is currently recruiting patients (Current: 23 Nov 2006)
• DNK333 - Efficacy and Safety of DNK333 in Women With Diarrhea-Predominant Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Desipramine - Treatment of Functional Bowel Disorders - This study has been completed (Current: 23 Nov 2006)
• Dexloxiglumide - DARWIN Study: A Randomization/Withdrawal Efficacy Study of Dexloxiglumide in C-IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dextromethorphan - Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Diet - Effect of Butyrogenic Fibers in IBS Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Duloxetine - An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• E. Coli Strain M17 Probiotic - Study to Determine the Effectiveness of the Probiotic E. Coli Strain M17 in Treating Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fentanyl - Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW427353 - A Study To Investigate GW427353 In Subjects With Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW427353 - A Study To Investigate The Effect Of GW427353 On Gastrointestinal Transit In Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW876008 - Effects Of GW876008 On The Stomach In Patients With Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW876008 - Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Lactobacillus plantarum MF 1298 - Probiotics for Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Lidocaine - Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lubiprostone - Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Lubiprostone - Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• MD-1100 Acetate - Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Naloxone - Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• PD-217,014 - A Study To Investigate The Effect Of PD-217,014 On Abdominal Pain/Discomfort In Patients With IBS. - This study has been completed (Current: 23 Nov 2006)
• Placebo - A Study To Investigate GW427353 In Subjects With Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - A Study To Investigate The Effect Of GW427353 On Gastrointestinal Transit In Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Brain Imaging and Pain in Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Probiotic bacteria (Trevis R) - The Effect of Probioticson Bloating in IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Psyllium Fibre (Dietary Supplement) - Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or No Fibre? - This study is currently recruiting patients (Current: 23 Nov 2006)
• Renzapride - Investigation of the Safety and Efficacy of Renzapride in Constipation Predominant Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rice Wheat (Placebo) - Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or No Fibre? - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rifaximin - Rifaximin for the Treatment of Irritable Bowel Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Rifaximin - Study to Assess the Efficacy and Safety of Rifaximin Administered BID in the Treatment of Patients With Diarrhea-Associated Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Talnetant - Eight-Weeks Of Treatment With Talnetant In Subjects With Irritable Bowel Syndrome (IBS) - This study has been completed (Current: 23 Nov 2006)
• Tegaserod - The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• VSL#3 - Dose Ranging Study With the Probiotic Combination (VSL#3) in Diarrhea IBS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Wheat Bran (Dietary Supplement) - Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or No Fibre? - This study is currently recruiting patients (Current: 23 Nov 2006)
• YM060 - A Study of YM060 in Diarrhea-Predominant Irritable Bowel Syndrome (d-IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• YM060 - Phase 3 Study of YM060 in Patients With Diarrhea-Predominant Irritable Bowel Syndrome (d-IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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