Treatments for Juvenile myoclonic epilepsy
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Epilepsy:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Generally, treatment of epilepsy consists of anticonvulsant therapy to reduce the number of future seizures. The most commonly prescribed drugs include phenytoin, carbamazepine, phenobarbital, gabapentin, or primidone administered individually for generalized tonic-clonic seizures and complex partial seizures. Valproic acid, clonazepam, and ethosuximide are commonly prescribed for absence seizures. Gabapentin and felbamate are also anticonvulsant drugs.
A patient taking anticonvulsant medications requires monitoring for toxic signs: nystagmus, ataxia, lethargy, dizziness, drowsiness, slurred speech, irritability, nausea, and vomiting.
If drug therapy fails, treatment may include surgical removal of a demonstrated focal lesion to attempt to stop seizures. Emergency treatment of status epilepticus usually consists of diazepam (or lorazepam), phenytoin, or phenobarbital; dextrose 50% I.V. (when seizures are secondary to hypoglycemia); and thiamine I.V. (in chronic alcoholism or withdrawal).
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Epilepsy:
Treatment
(Handbook of Diseases)
Therapy includes treatment of the underlying disorder or condition causing the seizures, avoidance of precipitating factors, suppression of recurrent seizures by prophylactic therapy, antiepileptic medications or surgery, and addressing psychological and social issues.
Generally, treatment of epilepsy consists of drug therapy specific to the type of seizure. The most commonly prescribed drugs include phenytoin, carbamazepine, phenobarbital, valproic acid, and primidone administered individually for generalized tonic-clonic seizures and complex partial seizures.
CLINICAL TIP: I.V. fosphenytoin is an alternative to phenytoin that’s just as effective, with a long half-life and minimal central nervous system depression. In addition, it can be administered rapidly without the adverse cardiovascular effects that occur with phenytoin.
Valproic acid, clonazepam, and ethosuximide are commonly prescribed for absence seizures. A patient taking an anticonvulsant requires monitoring for signs of toxicity, such as nystagmus, ataxia, lethargy, dizziness, drowsiness, slurred speech, irritability, nausea, and vomiting.
If drug therapy fails, a vagus nerve stimulator implant may help reduce the incidence of focal seizure. Transcranial magnetic stimulators are also under study and have been shown to help some patients. Treatment may also include surgical removal of a demonstrated focal lesion in an attempt to stop seizures.
CLINICAL TIP: Some children may respond to a ketogenic diet, rich in fats and low in carbohydrates. A dietitian should be consulted if this is prescribed.
Emergency treatment of status epilepticus usually consists of I.V. administration of diazepam, lorazepam, phenytoin, or phenobarbital; dextrose 50% (when seizures are secondary to hypoglycemia); and thiamine (in chronic alcoholism or withdrawal).
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
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