As with all medical conditions, there may be many causal factors. Further relevant information on causes of Klinefelter syndrome may be found in:
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Klinefelter's syndrome, probably the most common cause of hypogonadism, appears in approximately 1 in every 500 males. This disorder usually results from one extra X chromosome, giving such patients a 47,XXY complement instead of the normal 46,XY. (See Fertilization in Klinefelter's syndrome, page 36.) In the rare mosaic form of this syndrome, some cells contain the extra X chromosomes, whereas others contain the normal XY complement.
The extra chromosome responsible for Klinefelter's syndrome probably results from either meiotic nondisjunction during parental gametogenesis or from meiotic nondisjunction in the zygote. The incidence of meiotic nondisjunction increases with maternal age.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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