1 per 500 - 1,000 males are affected by Klinefelter syndrome, Genetics Home Reference website ... see also overview of Klinefelter syndrome.
approx 1 in 500 or 0.20% or 544,000 people in USA [Source statistic for calcuation: "1 per 500 - 1,000 males are affected by Klinefelter syndrome, Genetics Home Reference website" -- see also general information about data sources]
Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Klinefelter syndrome as a "rare disease". More information about Klinefelter syndrome is available from Orphanet
1-in-500 to 1-in-1000 male births (NIDCD) ... see also overview of Klinefelter syndrome.
approx 1 in 68,000 or 0.00% or 4,000 people in USA [Source statistic for calcuation: "1-in-500 to 1-in-1000 male births (NIDCD)" -- see also general information about data sources]
4,000 per year, 333 per month, 76 per week, 10 per day, 0 per hour, 0 per minute, 0 per second. [Source statistic for calculation: "1-in-500 to 1-in-1000 male births (NIDCD)" -- see also general information about data sources]
The following statistics relate to the incidence of Klinefelter syndrome:
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Klinefelter syndrome.
Klinefelter's syndrome, probably the most common cause of hypogonadism, appears in approximately 1 in every 500 males. This disorder usually results from one extra X chromosome, giving such patients a 47,XXY complement instead of the normal 46,XY. (See Fertilization in Klinefelter's syndrome, page 36.) In the rare mosaic form of this syndrome, some cells contain the extra X chromosomes, whereas others contain the normal XY complement.
The extra chromosome responsible for Klinefelter's syndrome probably results from either meiotic nondisjunction during parental gametogenesis or from meiotic nondisjunction in the zygote. The incidence of meiotic nondisjunction increases with maternal age.
Source: Professional Guide to Diseases (Eighth Edition), 2005
The term 'prevalence' of Klinefelter syndrome usually refers to the estimated population of people who are managing Klinefelter syndrome at any given time. The term 'incidence' of Klinefelter syndrome refers to the annual diagnosis rate, or the number of new cases of Klinefelter syndrome diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.
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