Causes: Lesch-Nyhan syndrome:
These raw materials are called purines, and they are an essential part of DNA and RNA. The body can either make purines (de novo synthesis) or recycle them (the resalvage pathway). Many enzymes are involved in these pathways. When one of these enzymes is missing, a wide range of problems can occur.
(Source: Genes and Disease by the National Center for Biotechnology)
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Lesch-Nyhan syndrome may be found in:
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