What is Leukocyte Adhesion Defect?

What is Leukocyte Adhesion Defect?

• Leukocyte Adhesion Defect: A rare inherited disorder characterized by abnormal neutrophil functioning which reduces the body's immunity. The abnormal neutrophils are unable to be transported to sites of infection due to their inability to adhere to certain blood vessel components which would normally lead them to the infection site. Infections may be life-threatening as the body is unable to destroy bacteria effectively.

Leukocyte Adhesion Defect is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Leukocyte Adhesion Defect, or a subtype of Leukocyte Adhesion Defect, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Leukocyte Adhesion Defect: Introduction

Types of Leukocyte Adhesion Defect:

Broader types of Leukocyte Adhesion Defect:

• Primary Immune Deficiency
• Immune disorders
• more types...»

How serious is Leukocyte Adhesion Defect?

Complications of Leukocyte Adhesion Defect: see complications of Leukocyte Adhesion Defect

What causes Leukocyte Adhesion Defect?

Causes of Leukocyte Adhesion Defect: see causes of Leukocyte Adhesion Defect

What are the symptoms of Leukocyte Adhesion Defect?

Symptoms of Leukocyte Adhesion Defect: see symptoms of Leukocyte Adhesion Defect

Complications of Leukocyte Adhesion Defect: see complications of Leukocyte Adhesion Defect

Onset of Leukocyte Adhesion Defect: usually early childhood

Leukocyte Adhesion Defect: Testing

Diagnostic testing: see tests for Leukocyte Adhesion Defect.

Misdiagnosis: see misdiagnosis and Leukocyte Adhesion Defect.

How is it treated?

Treatments for Leukocyte Adhesion Defect: see treatments for Leukocyte Adhesion Defect
Research for Leukocyte Adhesion Defect: see research for Leukocyte Adhesion Defect

Organs Affected by Leukocyte Adhesion Defect:

Organs and body systems related to Leukocyte Adhesion Defect include:

• Immune system

Name and Aliases of Leukocyte Adhesion Defect

Main name of condition: Leukocyte Adhesion Defect

LAD, Leucocyte adhesion defect

LAD 1, LFA 1 immunodeficiency, Lymphocyte function-associated antigen 1 immunodeficiency, Leukocyte adhesion deficiency type 1
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Research the causes of these diseases that are similar to, or related to, Leukocyte Adhesion Defect:

• Localized bacterial infections
• CDG-IIc
• Neutropenia
• Leukocytosis
• Congenital disorders of glycosylation
• Dysfunctional lipid-linked oligosaccharide precursor synthesis
• Dysfunctional trimming/processing of the protein-bound oligosaccharide
• Aseptic meningitis

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