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Diagnosis of Leukocyte Adhesion Defect

Leukocyte Adhesion Defect Diagnosis: Book Excerpts

Diagnostic Tests for Leukocyte Adhesion Defect: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about diagnostis of Leukocyte Adhesion Defect.


Leukocytosis: Differential Diagnosis
(In A Page: Pediatric Signs and Symptoms)

  • Neutrophilia
    –Increased production: Chronic infection or inflammation, tumor, drug-related, myeloproliferative disorders, chronic idiopathic neutrophilia, leukemoid reaction (Down syndrome, sepsis), chronic blood loss
    –Increased release from marrow/ demargination: Corticosteroids, stress, exercise, hypoxia, endotoxin, acute infection
    –Decreased removal from circulation due to splenectomy/asplenia, corticosteroids, leukocyte adhesion deficiency
    –Others: Hemolysis, infarction, diabetic ketoacidosis, renal failure, hepatic failure, thyrotoxicosis
  • Lymphocytosis
    –Infection: EBV, CMV
    –Heme/onc: Leukemia, neutropenia
    –Endocrine: Thyrotoxicosis, Addison
  • Basophilia
    –Infection: Sinusitis, Varicella, smallpox
    –Endocrine: Hypothyroidism, ovulation, pregnancy, stress
    –Drugs
    –Heme/onc: Hemolytic anemia, Hodgkin disease, CML, polycythemia vera
    –Inflammatory/collagen vascular disease
  • Monocytosis
    –Infection: Syphilis, tuberculosis, subacute bacterial endocarditis, malaria, typhoid fever, Rocky Mountain spotted fever
    –Heme/onc: Recovering marrow, hemolysis/hemolytic anemia, leukemias, Hodgkin disease, non-Hodgkin lymphoma, postsplenectomy, myeloproliferative disorders, congenital and acquired neutropenia, metastatic solid tumors
    –Chronic inflammatory, collagen vascular
    • Eosinophilia: Can be inherited
      –Allergy/asthma; parasitic infection
      –Heme/onc: Hodgkin disease, leukemias, immunodeficiency, postsplenectomy, solid tumors, pernicious anemia
      –Chronic inflammatory/collagen vascular/
    • Other: Rheumatoid arthritis, periarteritis nodosa, cirrhosis, Loeffler syndrome, sarcoid, dialysis

Workup and Diagnosis

  • History: Duration of leukocytosis; fever, frequent infections, cough, acute illness; symptoms associated with malignancy (malaise, lethargy, night sweats, bruising, weight loss, bone pain, epistaxis, bleeding gums, hematochezia, petechiae); known allergies/sensitivities; joint symptoms; bowel habits (diarrhea with parasites), travel; steroid use; radiation therapy; failure to thrive, delayed puberty
  • Family history: Myeloproliferative disease, hematologic malignancies, sarcoid, hepatosplenomegaly, early infant death
  • Physical exam: General appearance, growth parameters; iritis, uveitis, mucositis, allergic shiners, pharyngeal cobblestoning; rash, purpura, petechiae, ecchymoses, striae; lymph nodes; hepatomegaly, splenomegaly; thryoid exam; joint swelling, decreased range of motion
  • Labs
    –CBC with differential and peripheral smear, ESR
    –Leukocyte alkaline phosphatase
    –Liver and renal function
    –Stool hemoccult
    –Specific infectious titers
    –Specific autoimmune or rheumatologic tests
  • Studies (as indicated by history and physical exam)
    –CXR
    –Bone marrow exam

» READ BOOK EXCERPT ONLINE »

Source: In A Page: Pediatric Signs and Symptoms, 2007

LEUKOCYTOSIS: Approach to the Diagnosis
(Differential Diagnosis in Primary Care)

Because infection is the most common and often the most life-threatening cause, the history and physical are of most importance in locating a source. All suspicious body fluids should be analyzed and cultured. Urinalysis, urine culture, blood cultures and spinal fluid cultures are just a few. It is important to look at the blood smear and differential count. If the count is very high, a pathologist or hematologist should be called in without delay. An infectious disease specialist may be necessary.

» READ BOOK EXCERPT ONLINE »

Source: Differential Diagnosis in Primary Care, 2007

LEUKOCYTOSIS: Approach to the Diagnosis
(Differential Diagnosis in Primary Care)

Because infection is the most common and often the most life-threatening cause, the history and physical are of most importance in locating a source. All suspicious body fluids should be analyzed and cultured. Urinalysis, urine culture, blood cultures, and spinal fluid cultures are just a few. It is important to look at the blood smear and differential count. If the count is very high, a pathologist or hematologist should be called in without delay. An infectious disease specialist may be necessary.

» READ BOOK EXCERPT ONLINE »

Source: Differential Diagnosis in Primary Care, 2007


 » Next page: Signs of Leukocyte Adhesion Defect

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