Glossary for Leukocyte Adhesion Defect

• Congenital Disorders of Glycosylation: Congenital disorders of glycosylation is a group of disorders involving abnormally synthesis of N-linked oligosaccharides. There is a long chain of events involved in the synthesis and defects may occur with any of the compounds or enzymes involved in the process. Progressive impairment and regression of skills often occurs after a period of normal development following birth.
• Digestive symptoms: Any symptoms affecting the digestive tract.
• Gum symptoms: Dental symptoms affecting the gums
• Immune disorders: Disorders that affect the immune system
• Immune symptoms: Symptoms affecting the immune system
• Infection: Infections as a symptom.
• Leukocyte adhesion deficiency type 1: A rare inherited disorder characterized by abnormal neutrophil functioning which reduces the body's immunity. The abnormal neutrophils are unable to be transported to sites of infection due to their inability to adhere to certain blood vessel components which would normally lead them to the infection site. Infections may be life-threatening as the body is unable to destroy bacteria effectively. Type 1 LAD specifically involves a lack of receptor proteins on the neutrophil which prevents it from adhering.
• Leukocytosis: Increased concentration of white blood cells in the blood.
• Neutropenia: Reduced number of granulocytes in the blood
• Primary Immune Deficiency: Various types of immune deficiencies; usually genetic.
• Skin infections: Infection or inflammation of the skin.

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