Conditions here are listed
according to
social costs, which are the
estimated US dollar costs of the condition.
In most cases, the source data refers to the USA
or other industrialized nations.
| Condition | Cost ($) | Data |
| 1. Cardiovascular Disease | 329.2 billion | $329.2 billion with $199.5b direct, $30.9b morbidity, $98.8b mortality (NHLBI 2002) |
| 2. Injury | 259 billion | estimated $260 billion (IOM) |
| 3. Heart disease | 213 billion | $214.0 billion with $115.0b direct, $19.0b morbidity, $80.0b mortality (NHLBI 2002) |
| 4. Alcoholism | 184 billion | $185 billion each year for alcoholism in the US (Mayo Clinic) |
| 5. Occupational Injuries | 120 billion | more than $121 billion annually (CDC-OC) |
| 6. Lung conditions | 115.9 billion | $115.9 billion with $65.4b direct, $23.8b morbidity, $26.7b mortality (NHLBI 2002) |
| 7. Coronary heart disease | 111.8 billion | $111.8 billion with $58.2b direct, $8.4b morbidity, $45.b mortality (NHLBI 2002) |
| 8. Digestive Diseases | 106 billion | $107 billion in the USA 1992 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994) |
| 9. Overweight | 99.2 billion | $99.2 billion total including direct $51.6 billion and indirect $47.6 billion (NIDDK) |
| 10. Alzheimer's Disease | 80 billion | $80 to $100 billion in health care expenses and lost wages of both patients and their caregivers (NIA) |
| 11. Stroke | 49.4 billion | $49.4 billion with $30.8b direct, $5.6b morbidity, $13.0b mortality (NHLBI 2002) |
| 12. Hypertension | 47.2 billion | $47.2 billion with $34.4b direct, $6.7b morbidity, $6.1bb mortality (NHLBI 2002) |
| 13. Obesity | 32 billion | $33 billion annually spent on weight-loss products and services (NIDDK) |
| 14. COPD | 32.1 billion | $32.1 billion with $18.0b direct, $6.8b morbidity, $7.3b mortality (NHLBI 2002) |
| 15. Drug-resistant infectious agents | 30 billion | as high as $30 billion (NIAID) |
| 16. Congestive Heart Failure | 23.2 billion | $23.2 billion with $21.4b direct, unavailable morbidity, $1.8b mortality (NHLBI 2002); $3.4 billion was paid by Medicare in 1995 (CDC-OC) |
| 17. End-stage renal disease | 22.8 billion | $22.8 billion in public and private spending for ESRD program costs in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003) |
| 18. Allergies | 17 billion | $18 billion annually (NIAID) |
| 19. Sexually Transmitted Diseases | 17 billion | approximately $17 billion including HIV (NIAID) |
| 20. Osteoporosis | 17 billion | $17 billion in direct expenditure in the USA (National Osteoporosis Foundation, 2004) |
| 21. Medical misadventure | 17 billion | $17 to $29 billion per year (Institute of Medicine report). |
| 22. Urinary Incontinence | 16.3 billion | $16.3 billion in the USA 2001 (Obstetrics and Gynecology, 98:398-406, 2001) |
| 23. Arthritis | 15.2 billion | $15.2 billion annually |
| 24. Asthma | 13 billion | $14.0 billion with $9.4b direct, $2.7b morbidity, $1.9b mortality (NHLBI 2002) |
| 25. Migraine | 12 billion | $13 billion in missed work or reduced productivity annually (NINDS) |
| 26. Blood conditions | 9.7 billion | $9.7 billion with $7.1b direct, $0.7b morbidity, $1.9b mortality (NHLBI 2002) |
| 27. Obsessive-compulsive disorder | 8.4 billion | $8.4 billion in 1990 in social and economic losses in the USA (NIMH) |
| 28. Pelvic Inflammatory Disease | 6 billion | estimated $7 billion in 1997 (NIAID) |
| 29. HIV/AIDS | 6.7 billion | approximately $6.7 billion in 1994 (NIAID) |
| 30. Anemia | 6.4 billion | $6.4 billion with $4.9b direct, $0.6b morbidity, $0.9b mortality (NHLBI 2002) |
| 31. Peptic Ulcer | 5 billion | $6 billion annually (DBMD) |
| 32. Sinusitis | 5.8 billion | more than $5.8 billion in 1996 (NIAID) |
| 33. Chronic Sinusitis | 5.8 billion | more than $5.8 billion in US health care expenditure (NIAID) |
| 34. Food poisoning | 5 billion | $5 to $6 billion (NIAID) |
| 35. Nosocomial infections | 4.5 billion | more than $4.5 billion in 1992 (CDC/NNIS 1992) |
| 36. Human Papillomavirus | 3.8 billion | estimated $3.8 billion in 1994 (NIAID) |
| 37. Heart failure | 3.4 billion | $3.4 billion in 1995 in the USA |
| 38. Autism | 2 billion | more than $3 billion each year in health and educational services (NIMH) |
| 39. Chlamydia | 2 billion | more than $2 billion |
| 40. Urinary stones | 1.8 billion | $1.83 billion (direct and indirect) for evaluation and treatment in the USA 1993 (Journal of Urology, 1995) |
| 41. Kidney stones | 1.8 billion | $1.83 billion was spent on indirectly and directly on the evaluation and treatment of kidney stones in the US 1993 (Weighted Analysis of 1999 NAMCS, 2003, NIDDK) |
| 42. Gonorrhea | 1.1 billion | almost $1.1 billion (NIAID) |
| 43. Rotavirus | 1 billion | more than $1 billion in total costs to society including $264 million direct costs (CDC-OC) |
| 44. Chickenpox | 918 million | estimated $918 million in 1993 |
| 45. Cervical Cancer | 736 million | approximately $737 million |
| 46. Hepatitis C | 600 million | $600 million (CDC-OC) |
| 47. Group B Streptococcal Infections | 293 million | $294 million annually in direct medical costs of neonatal disease before prevention (DBMD) |
| 48. Guillain-Barre Syndrome | 247 million | $247 million to $1.8 billion for Campylobacter induced GBS (NIAID) |
| 49. Genital herpes | 237 million | approximately $237 million in 1994 (NIAID) |
| 50. Hepatitis A | 200 million | $200 million in 1991 (CDC-OC) |
| 51. Hepatitis B | 156 million | $156 million in 1994 (NIAID) |
| 52. Syphilis | 106 million | estimated $106 million in 1994 (NIAID) |
| 53. Lyme disease | 60 million | estimated $60 million a year (NIAID) |
| 54. Japanese encephalitis | 1 million | less than $1 million annually (DVBID) |
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