TREATMENTS &
RESEARCH
Search the
latest
treatment
information
here.
latest
treatment
information
here.
Dr. Huntley's
Diagnosis
Checklist
Have a symptom?
See what questions
a doctor would ask.
See what questions
a doctor would ask.
Conditions by People Affected (Prevalence or Incidence)
Conditions here are listed by a combined measure of either prevalence or incidence. This gives an approximate measure of the "people affected" by the condition in any year. Prevalence refers to the total pool of people affected, whereas incidence is the annual number of new cases. Lifelong diseases like diabetes can have a low incidence but a large cumulative prevalence count, whereas short-lived diseases like flu can have a high incidence but a low prevalence. For comparison between prevalence and incidence rates see also our conditions by prevalence and conditions by incidence. See also details about prevalence and incidence statistics for more information.
In most cases, the prevalence counts
and incidence rates refer to the USA
or other industrialized nations.
Our estimates show
274
conditions affecting a million or more Americans,
184
conditions between 100,000 and a million,
and
10687
conditions of less than 100,000 US people.
| Condition | Percent | Rate | US People | Data |
| 1. Diarrhea | 100.00% | 1 in 1 | 272 million | almost 100% annually (NIDDK) |
| 2. Common Headache | 90.00% | 1 in 1 | 244.8 million | 90% approximately; almost everyone gets some each year. |
| 3. Respiratory conditions | 78.90% | 1 in 1 | 214.6 million | 78.9 per 100 (NHIS96) |
| 4. Nonsyndromic deafness | 70.00% | 1 in 1 | 190.4 million | 70-80% of cases of congenital hearing loss are not associated with any syndrome in the US, Genetics Home Reference website |
| 5. Dental caries | 55.57% | 1 in 2 | 151.2 million | 2,534,161 annual cases in Victoria 1996 (DHS-VIC) |
| 6. Cytomegalovirus | 50.00% | 1 in 2 | 136 million | 50% approximately; almost half of young adults (NIAID) |
| 7. Cold sores | 50.00% | 1 in 2 | 136 million | estimated 50 to 80% of Americans have HSV-1 |
| 8. Refractive Eye Disorders | 44.12% | 1 in 2 | 120 million | 120 million people |
| 9. High Cholesterol | 37.13% | 1 in 3 | 101 million | estimated 101 million Americans have cholesterol >= 200 mg/dL (CDC) |
| 10. Infectious Diarrhea | 36.40% | 1 in 3 | 99 million | 99 million new cases in the USA 1980 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 11. Flu | 36.00% | 1 in 3 | 97.9 million | 36 per 100 (NHIS96); 35 million annually up to 50 million annually (NIAID/CDC); 10-20% yearly (NIAID) |
| 12. Overweight | 35.70% | 1 in 3 | 97.1 million | 97.1 million American adults |
| 13. Chronic Illness | 33.09% | 1 in 3 | 90 million | 90 million people in USA (CDC) |
| 14. Tetrahydrobiopterin Deficiency | 30.00% | 1 in 3 | 81.6 million | 30% of infants born with high phenylalanine levels have tetrahydrobiopterin deficiency in China, Genetics Home Reference website |
| 15. Familial atrial fibrillation | 30.00% | 1 in 3 | 81.6 million | estimated 30% of cases of atrial fibrillation are inherited (familial), Genetics Home Reference website |
| 16. Food poisoning | 27.94% | 1 in 3 | 76 million | about 76 million cases annually in USA (NIDDK) |
| 17. Myopia | 25.74% | 1 in 3 | 70 million | 70 million Americans; over 25 percent of all adult Americans. |
| 18. Insulin Resistance | 25.00% | 1 in 4 | 68 million | about 25% of the USA population have insulin resistance |
| 19. Metabolic Syndrome | 25.00% | 1 in 4 | 68 million | about 25% of the USA population have insulin resistance |
| 20. Genital herpes | 24.63% | 1 in 4 | 67 million | 67 million people (NIAID) |
| 21. Sexually Transmitted Diseases | 23.90% | 1 in 4 | 65 million | 65 million people living with an incurable STD (CDC) |
| 22. Common cold | 22.79% | 1 in 4 | 62 million | 62 million cases (NIAID); 23.6 per 100 (NHIS96); estimated 1 billion colds in the USA annually; Children get 6-10 yearly, adults 2-4 yearly; over 60's less than 1 a year. |
| 23. Cardiovascular Disease | 22.72% | 1 in 4 | 61.8 million | 61,800,000 cases in the USA (American Heart Association, 2004) |
| 24. Hyperopia | 22.40% | 1 in 4 | 60.9 million | 22.4% of population self-reported having long-sightedness in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW) |
| 25. Smoking | 22.30% | 1 in 4 | 60.7 million | 22.3% of Americans smoke (CDC); 23 million American women smoke (NHLBI) |
| 26. Mental illness | 22.10% | 1 in 4 | 60.1 million | about 22.1 percent of American adults annually or 44.3 million people (NIMH) |
| 27. Toxoplasmosis | 22.06% | 1 in 4 | 60 million | More than 60 million in USA but few have symptoms (DPD) |
| 28. Digestive Diseases | 22.06% | 1 in 4 | 60 million | 60 to 70 million cases in the USA 1985 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447) |
| 29. Injury | 21.69% | 1 in 4 | 59 million | 59 million cases (IOM) |
| 30. Epstein-Barr virus | 20.00% | 1 in 5 | 54.4 million | as many as 20% of people carry the virus in their throats |
| 31. Hypertension | 18.38% | 1 in 5 | 50 million | 50 million Americans (NHLBI); 217 per 1000 (NHIS95) |
| 32. Dandruff | 18.38% | 1 in 5 | 50 million | 50 million |
| 33. Allergies | 18.38% | 1 in 5 | 50 million | 50-60 million (NIAID); 9-16% (NIAID); 50 million cases annually (NIAID); 10% of American women (NHWIC); 8,526,000 children respiratory allergies (NHIS-97); 7,304,000 children non-respiratory allergies (NHIS-97) |
| 34. Headache | 16.54% | 1 in 6 | 45 million | 45 million Americans get chronic headaches. 20 million American women (NWHIC). |
| 35. Chronic headache | 16.54% | 1 in 6 | 45 million | estimated 45 million Americans (NINDS) |
| 36. Astigmatism | 16.54% | 1 in 6 | 45 million | 45 million Americans (dubious estimate based on "two thirds of people with myopia also have astigmatism") |
| 37. Anxiety Disorders | 16.40% | 1 in 6 | 44.6 million | estimated 16.4% adults (USSG); 19.1 million American adults (NIMH); 13.3% of adults (NIMH) |
| 38. Impaired glucose tolerance | 15.07% | 1 in 6 | 41 million | estimated 41 million people aged 40-74 have pre-diabetes in the US 1988-94 (National Diabetes Statistics fact sheet, NIDDK, 2003) |
| 39. Premenstrual syndrome | 15.00% | 1 in 6 | 40.8 million | 30-40% women suffer some impairment of daily activity (NWHIC); 75% women have some symptoms; 3-8% women have severe PMS (NWHIC). |
| 40. Hives | 15.00% | 1 in 6 | 40.8 million | about 15% Americans each year (NWHIC) |
| 41. Orthopedic disorders | 14.90% | 1 in 6 | 40.5 million | 149 per 1000 - NHIS95 |
| 42. Sleep disorders | 14.71% | 1 in 6 | 40 million | approximately 40 million Americans (NHLBI) |
| 43. Obesity | 14.63% | 1 in 6 | 39.8 million | 39.8 million American adults; more than 57% of American adults are overweight (CDC) |
| 44. Arthritis | 13.60% | 1 in 7 | 37 million | 37 million Americans (NIAMS) |
| 45. Sinusitis | 13.60% | 1 in 7 | 37 million | 37 million annually in the USA; 33 million reported to CDC (NIAID) |
| 46. Hay fever | 12.87% | 1 in 7 | 35 million | 35 million Americans (NIAID: pollen allergies) |
| 47. Pollen allergy | 12.87% | 1 in 7 | 35 million | estimated 35 million Americans with pollen allergies (NIAID) |
| 48. Androgenetic alopecia | 12.87% | 1 in 7 | 35 million | estimated 35 million men suffer from androgenetic alopecia in the US, Genetics Home Reference website |
| 49. Chronic Sinusitis | 12.83% | 1 in 7 | 34.9 million | 12.6% (NIAID); 152 per 1000 - NHIS95 |
| 50. Insomnia | 11.76% | 1 in 8 | 32 million | 32 million (unreliable estimate) |
| 51. Chronic lower respiratory diseases | 11.76% | 1 in 8 | 32 million | estimated 32 million including 15 million undiagnosed |
| 52. Lung conditions | 11.03% | 1 in 9 | 30 million | more than 30 million Americans with chronic lung diseases (NWHIC) |
| 53. Impotence | 11.03% | 1 in 9 | 30 million | 30 million men (NIDDK) |
| 54. Lactose Intolerance | 11.03% | 1 in 9 | 30 million | 30 million people to 50 million people (NIDDK 1994); about 25% of population (1994/NIDDK) |
| 55. Osteoporosis | 10.29% | 1 in 9 | 28 million | 28 million Americans (10 million with osteoporosis; 18 million with low bone mass); eight million American women and 2 million men (NWHIC) |
| 56. Migraine | 10.29% | 1 in 9 | 28 million | 28 million Americans (NINDS) |
| 57. Mole | 10.00% | 1 in 10 | 27.2 million | common; most people have 10-40 moles. |
| 58. Molluscum contagiosum | 10.00% | 1 in 10 | 27.2 million | Common. |
| 59. Scabies | 10.00% | 1 in 10 | 27.2 million | common |
| 60. Retroverted uterus | 10.00% | 1 in 10 | 27.2 million | about 1 in 5 women |
| 61. Subfertility | 10.00% | 1 in 10 | 27.2 million | about 1 in 10 couples |
| 62. Allergic rhinitis | 10.00% | 1 in 10 | 27.2 million | 10% of the population with allergic rhinitis/hay fever in the US (Mayo Clinic) |
| 63. Otosclerosis | 10.00% | 1 in 10 | 27.2 million | as many as 10% of Caucasians have the condition but most do not get symptoms; about 1 in 100 cases actually lose hearing from otosclerosis |
| 64. Extra Nipples | 10.00% | 1 in 10 | 27.2 million | about 1 in 10 people but most are small and mistaken for freckles or moles |
| 65. Glucose-6-Phosphate Dehydrogenase Deficiency | 10.00% | 1 in 10 | 27.2 million | 1 in 10 African-American males suffer from glucose-6-phosphate dehydrogenase deficiency in the US, Genetics Home Reference website |
| 66. Amyotrophic lateral sclerosis, familial | 10.00% | 1 in 10 | 27.2 million | 10% of all cases of amyotrophic lateral sclerosis are familial, Genetics Home Reference website |
| 67. Depressive disorders | 9.50% | 1 in 10 | 25.8 million | 9.5 percent of adult Americans (NIMH) |
| 68. Rare diseases | 9.19% | 1 in 10 | 25 million | about 25 million Americans (ORD); each disease less than 200,000 Americans by definition. |
| 69. Presbyopia | 9.00% | 1 in 11 | 24.5 million | 9.0% of population self-reported having presbyopia in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW) |
| 70. Back Impairment | 8.50% | 1 in 11 | 23.1 million | 85 per 1000 - NHIS95 (deformity or orthopedic impairment of back) |
| 71. Heart disease | 8.09% | 1 in 12 | 22 million | 22 million adults in the US 2000 (Centers for Disease Control and Prevention) |
| 72. Hearing Impairment | 8.09% | 1 in 12 | 22 million | 22 million; 158 per 1000 (NHIS95) |
| 73. Thyroid disorders | 7.35% | 1 in 13 | 20 million | 20 million Americans (NWHIC) |
| 74. Human Papillomavirus | 7.35% | 1 in 13 | 20 million | 20 million Americans currently infected (NIAID; CDC 2001) |
| 75. Osteoarthritis | 7.35% | 1 in 13 | 20 million | 20 million people (NIAMS); more than 16 million people (NWHIC) |
| 76. Mood disorders | 7.10% | 1 in 14 | 19.3 million | estimated 7.1% adults (USSG) |
| 77. Ischemic heart disease | 6.80% | 1 in 14 | 18.5 million | 68 per 1000 (NHIS95) |
| 78. Sleep apnea | 6.62% | 1 in 15 | 18 million | estimated 18 million Americans (NHLBI) |
| 79. Asthma | 6.40% | 1 in 15 | 17.4 million | 6.4% USA (NIAID); 17 million Americans (NIAID) including 5 million children; 8.1 million children (NHIS-97), 51 per 1000 - NHIS95; 14.5 million; 5% of population (NWHIC); 14.9 million in 1995 (NHLBI) |
| 80. Acne | 6.25% | 1 in 16 | 17 million | 17 million Americans, almost 85% of people 12-24 years of age. |
| 81. Diabetes | 5.88% | 1 in 17 | 16 million | 16 million Americans with 10.3 million diagnosed and 8.1 million women (NWHIC); 65 per 1000 - NHIS95; 8 million - perhaps 16 million if include not-yet-diagnosed. |
| 82. Type 2 diabetes | 5.88% | 1 in 17 | 16 million | 16 million Americans (NWHIC, includes undiagnosed); 7.2 million (actually diagnosed) |
| 83. Gallstones | 5.88% | 1 in 17 | 16 million | 16 to 22 million people in the USA 1976-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, NIDDK, 1994) |
| 84. Crouzon Syndrome | 5.88% | 1 in 17 | 16 million | 16 million newborns suffer from Crouzon syndrome, Genetics Home Reference website |
| 85. Alcoholism | 5.55% | 1 in 18 | 15.1 million | estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA) |
| 86. Alcohol abuse | 5.55% | 1 in 18 | 15.1 million | estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA) |
| 87. Eczema | 5.51% | 1 in 18 | 15 million | 15 million people (NIAMS); 10% infants/children estimated (NIAMS); 9% (NIAID); 8.5 million |
| 88. Gynecomastia | 5.51% | 1 in 18 | 15 million | 15 million - 15% of adult men to some extent (unreliable estimate) |
| 89. Heartburn | 5.51% | 1 in 18 | 15 million | 15 million Americans have it daily (NIDDK) |
| 90. Depression | 5.30% | 1 in 18 | 14.4 million | estimated 5.3% adults (USSG); 17 million people; approximately 4% of adolescents get seriously depressed (NIMH); annually 12% of women ; 7% of men; lifetime risk of an episode for women 20%. 3-4 million men USA. |
| 91. Arrhythmias | 5.30% | 1 in 18 | 14.4 million | 53 per 1000 (NHIS95: heart rhythm disorders); 21 per 1000 (NHIS95: heart murmurs) |
| 92. Urinary stones | 5.20% | 1 in 19 | 14.1 million | 5.2% of adults in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003) |
| 93. Raynaud's phenomenon | 5.00% | 1 in 20 | 13.6 million | 5-10% (NIAMS estimate). Scleroderma-related disorders including Raynaud's phenomenon between 250,000 and 992,500. |
| 94. Uterine fibroids | 5.00% | 1 in 20 | 13.6 million | 10-20% women (NWHIC) |
| 95. Endometriosis | 5.00% | 1 in 20 | 13.6 million | 10 to 20 percent of American women of childbearing age have endometriosis (NIDCD); up to 2 million women in the UK. |
| 96. Red-green color blindness | 5.00% | 1 in 20 | 13.6 million | about 10% of males |
| 97. Congenital myotonic dystrophy | 5.00% | 1 in 20 | 13.6 million | 5 per 100 000 people suffer from myotonic dystrophy in the US |
| 98. X-linked adrenoleukodystrophy - Addison disease only | 5.00% | 1 in 20 | 13.6 million | 10% of males with X-linked adrenoleukodystrophy have the Addison only form of the disease, Genetics Home Reference website |
| 99. Chronic Obstructive Pulmonary Disease | 4.96% | 1 in 20 | 13.5 million | 13.5 million Americans (NHLBI) |
| 100. Coronary heart disease | 4.85% | 1 in 20 | 13.2 million | estimated 13,200,000 in the USA 2001 (American Heart Association, 2004) |
| 101. Urinary Incontinence | 4.78% | 1 in 20 | 13 million | 13 million adults (NIDDK); 1 in 10 over 65 (NWHIC). |
| 102. Rosacea | 4.78% | 1 in 20 | 13 million | 13 million people in the United States (NIAMS) |
| 103. Acute Bronchitis | 4.60% | 1 in 21 | 12.5 million | 4.6 per 100 (NHIS96: acute bronchitis); 14.2 million cases annually |
| 104. Varicose veins | 4.50% | 1 in 22 | 12.2 million | 45 per 1000 (NHIS95) |
| 105. Tinnitus | 4.50% | 1 in 22 | 12.2 million | 45 per 1000 (NHIS95); 12 million Americans |
| 106. Chronic Bronchitis | 4.45% | 1 in 22 | 12.1 million | 12.1 million Americans (NHLBI) |
| 107. Obstructive sleep apnea | 4.41% | 1 in 22 | 12 million | 12 million Americans |
| 108. Genetic Disease | 4.41% | 1 in 22 | 12 million | 12 million Americans - unreliable estimate, (perhaps 2.5% births) |
| 109. Phobias | 4.23% | 1 in 23 | 11.5 million | 11.5 million adults (NIMH); 8.0% adults (NIMH) |
| 110. Iron deficiency anemia | 4.12% | 1 in 24 | 11.2 million | 187,979 annual cases in Victoria 1996 (DHS-VIC); 20% women of childbearing age; 2% adult men (NWHIC) |
| 111. Cornea disorders | 4.04% | 1 in 24 | 11 million | 11,000,000 people experience corneal disorders such as herpes or dry eye in the US (Research to Prevent Blindness, NISE, NSF) |
| 112. Dysthymia | 4.01% | 1 in 24 | 10.9 million | about 10.9 million American adults (NIMH); estimated 1.6% adults (USSG) |
| 113. Presbycusis | 3.90% | 1 in 25 | 10.6 million | 30-35% over 65 have some hearing loss, 40-50% over 70. |
| 114. Hemorrhoids | 3.82% | 1 in 26 | 10.4 million | 10.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 115. Social phobia | 3.70% | 1 in 27 | 10.1 million | 5.3 million adult Americans (NIMH); 3.7% adults (NIMH); 2.0% adults (USSG) |
| 116. Latent tuberculosis | 3.68% | 1 in 27 | 10 million | estimated 10 to 15 million people in USA (NIAID) |
| 117. Jaw conditions | 3.68% | 1 in 27 | 10 million | estimated 10 million women in the USA (NWHIC) |
| 118. Traveler's diarrhea | 3.68% | 1 in 27 | 10 million | estimated 10 million (DBMD) |
| 119. Enteroviruses | 3.68% | 1 in 27 | 10 million | estimated 10-15 million cases annually in USA (DVRD) |
| 120. Age-related macular degeneration | 3.68% | 1 in 27 | 10 million | 10,000,000 people have reduced vision due to age-related macular degeneration in the US (Research to Prevent Blindness, NISE, NSF) |
| 121. Post-traumatic stress disorder | 3.60% | 1 in 27 | 9.8 million | 5.2 million adult Americans (NIMH); 3.6% adults (NIMH); about 30% of war veterans. |
| 122. Indigestion | 3.50% | 1 in 28 | 9.5 million | 35 per 1000 - NHIS95 (frequent indigestion) |
| 123. Dermatitis | 3.30% | 1 in 30 | 8 million | 33 per 1000 (NHIS95) |
| 124. Insect sting allergies | 3.30% | 1 in 30 | 8 million | 3.3% (NIAID); up to 5% of the population (NHWIC) |
| 125. Bursitis | 3.20% | 1 in 31 | 8.7 million | 32 per 1000 (NHIS95) |
| 126. Autoimmune diseases | 3.13% | 1 in 31 | 8.5 million | 8,511,845 people in the USA 1996 1 |
| 127. Dry skin | 3.10% | 1 in 32 | 8.4 million | 31 per 1000 - NHIS95 (trouble with dry/itching skin) |
| 128. Disc Disorders | 3.10% | 1 in 32 | 8.4 million | 31 per 1000 (NHIS95: intervertebrate disc disorders) |
| 129. Acute urinary conditions | 3.09% | 1 in 32 | 8.4 million | 8.405 million new conditions (NIDDK) |
| 130. Acute Nonulcer dyspepsia | 3.01% | 1 in 33 | 8.2 million | 8.2 million new cases (1988/NIDDK) |
| 131. Paget's disease of bone | 3.00% | 1 in 33 | 8.2 million | about 3% of people aged over 40; 10% by age 80. |
| 132. Retinoblastoma | 3.00% | 1 in 33 | 8.2 million | 3% of cancers in children under the age of 15 are due to retinoblastomas, Genetics Home Reference website |
| 133. Congenital conditions | 3.00% | 1 in 33 | 8.2 million | 3-4% of babies (NWHIC) |
| 134. Gastroesophageal Reflux Disease | 3.00% | 1 in 33 | 8.2 million | 3-7% of the population in the USA 1985 for "GERD and related esophageal disorders" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 135. Urinary tract infections (child) | 3.00% | 1 in 33 | 8.2 million | 3% of girls and 1% of boys before age 11 |
| 136. Cerebrovascular Conditions | 3.00% | 1 in 33 | 8.2 million | 30 per 1000 - NHIS95 |
| 137. Amyotrophic lateral sclerosis type 1 | 3.00% | 1 in 33 | 8.2 million | 3% of sporadic cases of amyotrophic lateral sclerosis are type 1, Genetics Home Reference website |
| 138. Generalized anxiety disorder | 2.80% | 1 in 35 | 7.6 million | 4 million adult Americans (NIMH); 2.8% adults (NIMH); estimated 3.4% adults (USSG) |
| 139. Heart attack | 2.76% | 1 in 36 | 7.5 million | 7.5 million people with AMI (NHLBI) |
| 140. Squint | 2.76% | 1 in 36 | 7.5 million | 7,500,000 people suffer from strabismus or cross eyes in the US (Research to Prevent Blindness, NISE, NSF) |
| 141. Kidney disease | 2.72% | 1 in 36 | 7.4 million | 7.4 million adults in the USA 1988-94 (American Journal of Kidney Disease) |
| 142. Prostate conditions | 2.60% | 1 in 38 | 7.1 million | 52 per 1000 men - NHIS95; 2,803 million men (NIDDK) |
| 143. Ingrown nails | 2.60% | 1 in 38 | 7.1 million | 26 per 1000 - NHIS95 (trouble with ingrown nails) |
| 144. Middle ear infection | 2.57% | 1 in 38 | 7 million | 7 million annually |
| 145. Callus | 2.50% | 1 in 40 | 6.8 million | 25 per 1000 - NHIS95 (trouble with corns or calluses) |
| 146. Corns | 2.50% | 1 in 40 | 6.8 million | 25 per 1000 - NHIS95 (trouble with corns or calluses) |
| 147. Polycystic ovary syndrome | 2.50% | 1 in 40 | 6.8 million | 5-10% women of childbearing age (20-40); 30% of women have some PCOS symptoms (NWHIC). |
| 148. Fecal incontinence | 2.39% | 1 in 41 | 6.5 million | 6.5 million Americans |
| 149. Angina | 2.35% | 1 in 42 | 6.4 million | 6.4 million Americans (NHLBI) |
| 150. Specific phobias | 2.32% | 1 in 43 | 6.3 million | estimated 6.3 million adult Americans (NIMH); estimated 8.3% adults (USSG) |
| 151. Occupational Injuries | 2.32% | 1 in 43 | 6.3 million | 6.3 million workers in 1994 (CDC-OC) |
| 152. Obsessive-compulsive disorder | 2.30% | 1 in 43 | 6.3 million | 3.3 million adult Americans (NIMH); 2.3% adults (NIMH); 1 in 50 people (NWHIC); 2.4% adults (USSG) |
| 153. Cystitis | 2.28% | 1 in 43 | 6.2 million | 6.2 million adults self-reported having a bladder infection for more than 3 months in the US 1988-1994 (Weighted Analysis of 1988-1994, NHANES, NIDDK) |
| 154. Infertility | 2.24% | 1 in 44 | 6.1 million | 6.1 million people in 1997 (NWHIC); 5.3 million Americans or 9% of reproductive age (NWHIC/American Society for Reproductive Medicine) |
| 155. Back pain | 2.21% | 1 in 45 | 6 million | 6 million cases annually (unreliable estimate) |
| 156. Chest pain | 2.21% | 1 in 45 | 6 million | 6 million cases annually (unreliable estimate) |
| 157. Nonulcer dyspepsia | 2.13% | 1 in 46 | 5.8 million | 5.8 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994) |
| 158. Anti-Social Personality Disorder | 2.10% | 1 in 47 | 5.7 million | estimated 2.1% adults (USSG) |
| 159. Periodontitis | 2.07% | 1 in 48 | 5.6 million | 94,482 annual cases in Victoria 1996 (DHS-VIC) |
| 160. Cataracts | 2.02% | 1 in 49 | 5.5 million | 5,500,000 people have a cataract interfering with their vision in the US (Research to Prevent Blindness, NISE, NSF) |
| 161. Psoriasis | 2.02% | 1 in 49 | 5.5 million | 5.5 million people in the USA (NIAMS) |
| 162. Autoimmune thyroid diseases | 2.00% | 1 in 50 | 5.4 million | 4 out of 100 women some type of autoimmune thyroid disease |
| 163. Borderline Personality Disorder | 2.00% | 1 in 50 | 5.4 million | 2 percent of adults (NIMH) |
| 164. Cyclic vomiting syndrome | 2.00% | 1 in 50 | 5.4 million | 1 in 50 children (perhaps) |
| 165. Penicillin allergy | 2.00% | 1 in 50 | 5.4 million | 2-3% of people (2-3% of hospitalized patients) |
| 166. Mitral-valve prolapse | 2.00% | 1 in 50 | 5.4 million | 2% of the adult population (NHLBI estimate) |
| 167. Hereditary nonpolyposis colon cancer | 2.00% | 1 in 50 | 5.4 million | 2-7% of all colorectal cancers are due to hereditary nonpolyposis colorectal cancer |
| 168. Bunions | 1.92% | 1 in 51 | 5.2 million | 19.25 per 1000 - NHIS95 (trouble with bunions) |
| 169. Female genital disorders | 1.90% | 1 in 52 | 5.2 million | 38 per 1000 women (NHIS95) |
| 170. Trichomoniasis | 1.84% | 1 in 54 | 5 million | 5 million cases annually in the USA (CDC 2001) |
| 171. Irritable bowel syndrome | 1.84% | 1 in 54 | 5 million | 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, 1994); 11 per 1000 (NHIS95) |
| 172. Peptic Ulcer | 1.84% | 1 in 54 | 5 million | 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994) |
| 173. Eating disorders | 1.84% | 1 in 54 | 5 million | 5 million women (NWHIC); 1-4% of young women |
| 174. Pneumonia | 1.76% | 1 in 56 | 4.8 million | 4.8 million annual cases (1996); 1.8 per 100 (NHIS96) |
| 175. Heart failure | 1.76% | 1 in 56 | 4.8 million | 4.8 million (NHLBI); 2 to 3 million Americans (NHLBI) |
| 176. Congestive Heart Failure | 1.76% | 1 in 56 | 4.8 million | 4.8 million Americans (NHLBI); 2% age 40-59; 5% age 60-69; 10% over 70's |
| 177. Panic disorder | 1.70% | 1 in 58 | 4.6 million | approximately 2.4 million Americans (NIMH) |
| 178. Atherosclerosis | 1.70% | 1 in 58 | 4.6 million | 17 per 1000 - NHIS95 |
| 179. Learning disabilities | 1.69% | 1 in 59 | 4.6 million | 4.6 million children (NHIS-97) |
| 180. Stroke | 1.69% | 1 in 59 | 4.6 million | estimated 4.6 million (NHLBI) |
| 181. Automobile accidents injury | 1.68% | 1 in 59 | 4.6 million | 4,563,000 cases requiring emergency department visits in 2000 (CDC) |
| 182. Abdominal Hernia | 1.65% | 1 in 60 | 4.5 million | 4.5 million people in the USA 1988-90 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 183. Constipation | 1.62% | 1 in 61 | 4.4 million | 4.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 184. Edema | 1.60% | 1 in 62 | 4.4 million | 1.6% of population self-reported having oedema in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW) |
| 185. Tachycardia | 1.60% | 1 in 62 | 4.4 million | 16 per 1000 (NHIS95) |
| 186. Falls | 1.52% | 1 in 65 | 4.1 million | 69,264 annual cases in Victoria 1996 (DHS-VIC) |
| 187. Kidney conditions | 1.50% | 1 in 66 | 4.1 million | 15 per 1000 (NHIS95: "kidney trouble") |
| 188. Undescended Testicle | 1.50% | 1 in 66 | 4.1 million | 3% of male babies; about 30% of premature male babies. |
| 189. Childbirth | 1.49% | 1 in 67 | 4 million | 4,043,000 annual live births ending Aug 2001 (NVSR 50:7 2002); 4,058,814 annually in 1999 in USA (CDC) |
| 190. Shoulder conditions | 1.47% | 1 in 68 | 4 million | about 4 million annual cases in USA (NIAMS) |
| 191. Alzheimer's Disease | 1.47% | 1 in 68 | 4 million | more than 4 million Americans (CDC); estimated 4 million people in the U.S (NHWIC) |
| 192. Chlamydia | 1.47% | 1 in 68 | 4 million | estimated 4 million cases (NIAID/CDC) [4-8 million cases] including undiagnosed (about 600,000 diagnosed). |
| 193. Pregnancy | 1.47% | 1 in 68 | 4 million | more than 4 million; 1 million adolescent U.S. females become pregnant every year |
| 194. Drug abuse | 1.47% | 1 in 68 | 4 million | more than 4 million women need treatment for drug abuse (NWHIC) |
| 195. Chronic Hepatitis C | 1.47% | 1 in 68 | 4 million | Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK). |
| 196. Deafness | 1.47% | 1 in 68 | 4 million | 4 million people (unreliable estimate) |
| 197. Thrombotic thrombocytopenic purpura, acquired | 1.47% | 1 in 68 | 4 million | estimated 4-7 million people are diagnosed with thrombotic thrombocytopenic purpura each year in the US, Genetics Home Reference website |
| 198. Fibromyalgia | 1.36% | 1 in 73 | 3.7 million | 3.7 million Americans (NIAMS) |
| 199. Open Wound | 1.32% | 1 in 75 | 3.6 million | 60,052 annual cases of open wounds in Victoria 1996 (DHS-VIC) |
| 200. Color blindness | 1.30% | 1 in 76 | 3.5 million | 13 per 1000 - NHIS95 |
| 201. Anemia | 1.29% | 1 in 77 | 3.5 million | 3.5 million (NHLBI) |
| 202. Attention Deficit Hyperactivity Disorder | 1.21% | 1 in 82 | 3.3 million | 3.3 million children have ADD in USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH). |
| 203. Rheumatic fever | 1.20% | 1 in 83 | 3.3 million | 12 per 1000 (NHIS95) |
| 204. Bipolar disorder | 1.20% | 1 in 83 | 3.3 million | 1.2 percent of the population; 2.3 million adult Americans (NIMH) |
| 205. Colitis | 1.20% | 1 in 83 | 3.3 million | 12 per 1000 (NHIS95: "enteritis or colitis") |
| 206. Enteritis | 1.20% | 1 in 83 | 3.3 million | 12 per 1000 (NHIS95: "enteritis or colitis") |
| 207. Acute rheumatic fever | 1.20% | 1 in 83 | 3.3 million | 12 per 1000 (NHIS95) |
| 208. Agoraphobia | 1.18% | 1 in 84 | 3.2 million | approximately 3.2 million American adults ages 18 to 54 (NIMH); estimated 4.9% adults (USSG) |
| 209. Bladder conditions | 1.15% | 1 in 86 | 3.1 million | 3.139 million cases (chronic, NIDDK); 25 per 1000 - NHIS95 (bladder disorders) |
| 210. Graves Disease | 1.12% | 1 in 89 | 3 million | 3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC) |
| 211. Pubic lice | 1.10% | 1 in 90 | 3 million | 3 million new cases annually estimated (NIAID) |
| 212. Rotavirus | 1.10% | 1 in 90 | 3 million | 3 million cases in the USA each year. |
| 213. Von Willebrand disease | 1.10% | 1 in 90 | 3 million | estimated 3 million mostly undiagnosed |
| 214. Open-angle glaucoma | 1.10% | 1 in 90 | 3 million | about 3 million Americans, many not yet diagnosed. |
| 215. Peanut allergies | 1.10% | 1 in 90 | 3 million | 3 million Americans (peanut and tree nut combined; NIAID) |
| 216. Dental conditions | 1.10% | 1 in 90 | 2 million | 1.1 per 100 (NHIS96: acute dental conditions) |
| 217. Stuttering | 1.00% | 1 in 100 | 2.7 million | about 1% of adults |
| 218. Deuteranopia | 1.00% | 1 in 100 | 2.7 million | about 1% of white males |
| 219. Protanopia | 1.00% | 1 in 100 | 2.7 million | about 1% of white males |
| 220. Food allergies | 1.00% | 1 in 100 | 2.7 million | 1% of the adult population have a true immune reaction to food (NHWIC) |
| 221. Latex allergies | 1.00% | 1 in 100 | 2.7 million | 1-6% (NIAID) |
| 222. Speech impairment | 1.00% | 1 in 100 | 2.7 million | 10 per 1000 (NHIS95) |
| 223. Glomus vagale tumors | 1.00% | 1 in 100 | 2.7 million | 1% of glomus tumors are malignant |
| 224. Gastritis | 0.99% | 1 in 100 | 2.7 million | 2.7 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 225. Rheumatoid arthritis | 0.92% | 1 in 108 | 2.5 million | 2.5 million Americans (NWHIC); 1% of US population (NIAMS) |
| 226. Campylobacter food poisoning | 0.92% | 1 in 108 | 2.5 million | 2.5 million cases per year (CDC estimate/NIAID); 2 million cases to 8 million cases a year |
| 227. Paralysis | 0.90% | 1 in 111 | 2.4 million | 9 per 1000 - NHIS95 (paralysis of extremeties complete/partial) |
| 228. Vision Impairment | 0.88% | 1 in 113 | 2.4 million | 2.4 million Americans |
| 229. Death | 0.88% | 1 in 113 | 2.4 million | 2,391,399 annual deaths in 1999 (NVHS Sep 2001); annual risk of dying about 0.877% (NVSR 2001) |
| 230. Epilepsy | 0.85% | 1 in 118 | 2.3 million | 2.3 million Americans (CDC) |
| 231. Uveitis | 0.85% | 1 in 118 | 2.3 million | 2,300,000 people suffer uveitis in the US (Research to Prevent Blindness, NISE, NSF) |
| 232. Congenital heart defects | 0.83% | 1 in 120 | 2.3 million | 1 million (NHLBI) |
| 233. Schizophrenia | 0.81% | 1 in 123 | 2.2 million | Approximately 2.2 million American adults (NIMH); estimated 1.3% adults (USSG); more than 2 million Americans |
| 234. Adverse reaction | 0.81% | 1 in 123 | 2.2 million | 2.2 million adverse drug reactions after administration of FDA-approved drugs in USA 1996 (American Medical Association) |
| 235. Deviated Septum | 0.80% | 1 in 124 | 2.2 million | 8 per 1000 - NHIS95 |
| 236. Glaucoma | 0.74% | 1 in 136 | 2 million | 2,000,000 people are visually impaired by glaucoma in the US (Research to Prevent Blindness, NISE, NSF) |
| 237. Vitiligo | 0.74% | 1 in 136 | 2 million | 2 to 5 million people in the USA (1-2% worldwide); 1,059,560 people in the USA 1996 1 |
| 238. Male infertility | 0.74% | 1 in 136 | 2 million | at least 2 million annual cases (based on NWHIC) |
| 239. Female infertility | 0.74% | 1 in 136 | 2 million | at least 2 million annual cases (based on NWHIC) |
| 240. Diverticular Disease | 0.74% | 1 in 136 | 2 million | 2 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 241. Hepatitis C | 0.74% | 1 in 136 | 2 million | estimated 2 to 5 million HCV chronic carriers |
| 242. Alcoholic liver disease | 0.74% | 1 in 136 | 2 million | More than 2 million Americans (NIAAA) |
| 243. Emphysema | 0.74% | 1 in 136 | 2 million | 2 million Americans (NHLBI); 17 per 1000 - NHIS95; 2 million annually |
| 244. Nosocomial infections | 0.74% | 1 in 136 | 2 million | estimated 2 million cases annually or about 10% of American hospital patients (CDC/NNIS 1992) |
| 245. Atrial Fibrillation | 0.74% | 1 in 136 | 2 million | 2 million (NHLBI) |
| 246. Mycoplasma pneumoniae | 0.74% | 1 in 136 | 2 million | estimated 2 million cases annually (DBMD) |
| 247. Polymyalgia rheumatica | 0.70% | 1 in 142 | 1.9 million | 700 per 100,000 people over 50. |
| 248. Chronic tonsilitis | 0.70% | 1 in 142 | 1.9 million | 7 per 1000 - NHIS95 (chronic disease of tonsils or adenoids) |
| 249. Amputation | 0.70% | 1 in 142 | 1.9 million | 7 per 1000 (NHIS95: excludes toes/fingers only) |
| 250. Binge eating disorder | 0.70% | 1 in 142 | 1.9 million | 0.7% to 4% of the general population (NWHIC); 2-5% of adults (NIMH); 2% of adults (NIDDK); 2% adults or 1-2 million adults (NWHIC) |
| 251. Birth Injury | 0.70% | 1 in 142 | 1.9 million | 7 per 1,000 births2. |
| 252. Retina Conditions | 0.66% | 1 in 151 | 1.8 million | 1,800,000 people have severely impaired vision because of retinal disease in the US (Research to Prevent Blindness, NISE, NSF) |
| 253. Hepatitis B | 0.55% | 1 in 181 | 1.5 million | estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001) |
| 254. Fractures | 0.55% | 1 in 181 | 1.5 million | 1.5 million osteoporosis-related fractures |
| 255. Bulimia nervosa | 0.55% | 1 in 181 | 1.5 million | estimated 1.1 to 4.2 percent of females (NIMH); 2-3% of young women (NWHIC) |
| 256. Hashimoto's Thyroiditis | 0.55% | 1 in 182 | 1.5 million | 1,490,371 adults and 205,159 children in the USA 1996 1 |
| 257. Lupus | 0.51% | 1 in 194 | 1.4 million | 1.4 million people in the United States, 1 in 85 (NWHIC) |
| 258. Salmonella food poisoning | 0.51% | 1 in 194 | 1.4 million | estimated 1.4 million cases (CDC estimate/NIAID, many unreported) |
| 259. Mild Traumatic Brain Injury | 0.51% | 1 in 194 | 1.4 million | Estimated 1.4 million MTBI injuries per year in the USA (CDC) |
| 260. Wegener's granulomatosis | 0.50% | 1 in 200 | 1.4 million | uncommon |
| 261. HTLV | 0.50% | 1 in 200 | 1.4 million | uncommon |
| 262. HTLV-1 | 0.50% | 1 in 200 | 1.4 million | uncommon |
| 263. Peyronie's disease | 0.50% | 1 in 200 | 1.4 million | 1 per 100 men |
| 264. Sebaceous cyst | 0.50% | 1 in 200 | 1.4 million | 5 per 1000 - NHIS95 |
| 265. Cerebral cavernous malformations | 0.50% | 1 in 200 | 1.4 million | 0.5% of people suffer from cerebral cavernous malformations worldwide, Genetics Home Reference website |
| 266. Bladder Incontinence (Pregnancy) | 0.49% | 1 in 203 | 1.3 million | 1-in-3 pregnant women approximately |
| 267. Cancer | 0.46% | 1 in 217 | 1.2 million | 1,248,900 annual cases (SEER 2002 estimate) |
| 268. Medical misadventure | 0.42% | 1 in 238 | 1.1 million | 1.14 million total patient safety incidents occurred among 37 million hospitalisations in the US 2000-02 (Patient Safety in American Hospitals, Health Grades 2004) |
| 269. Blindness | 0.40% | 1 in 247 | 1.1 million | 1,100,000 people are legally blind in the US (Research to Prevent Blindness, NISE, NSF) |
| 270. Celiac Disease | 0.40% | 1 in 249 | 1.1 million | 1 in 250 Americans estimated rate; actual diagnosis rate is 1 in 4,700 Americans; 1 in 250 in Italy; 1 in 300 in Ireland; 20,000 diagnosed (Reader's Digest Feb 2004) |
| 271. 2-methylbutyryl-coenzyme A dehydrogenase deficiency | 0.40% | 1 in 249 | 1.1 million | 1 per 250 - 500 people from Hmong populations in southeast Asia and America suffer from 2-methylbutyryl-coenzyme A dehydrogenase deficiency though many are asymptomatic, Genetics Home Reference website |
| 272. Familial Mediterranean fever | 0.40% | 1 in 249 | 1.1 million | estimated 1 per 250 - 1,000 people of Armenian, Arabic, Turkish, Jewish and Mediterranean ancestry suffer from Familial Mediterranean Fever, Genetics Home Reverence website |
| 273. Arm fracture | 0.39% | 1 in 255 | 1.1 million | 17,819 annual cases in Victoria 1996 of radius/ulna (DHS-VIC) |
| 274. Sports Injuries | 0.38% | 1 in 260 | 1 million | 17,478 annual cases in Victoria 1996 (DHS-VIC) |
| 275. Skin Cancer | 0.37% | 1 in 272 | 1 million | more than 1 million annually (mostly the less dangerous types: basal and squamous) |
| 276. Sjogren's Syndrome | 0.37% | 1 in 272 | 1 million | 1 to 4 million people with Sjogren’s Syndrome (NIAMS) |
| 277. Connective tissue disorders | 0.37% | 1 in 272 | 1 million | estimated 1 million people in USA with heritable connective tissue disorder (NIAMS) |
| 278. Genital warts | 0.37% | 1 in 272 | 1 million | 1 million annual cases in the USA (NIAID) |
| 279. Pelvic Inflammatory Disease | 0.37% | 1 in 272 | 1 million | 1 million women have a PID episode each year (NIAID) |
| 280. Aphasia | 0.37% | 1 in 272 | 1 million | 1 million Americans (NINDS) |
| 281. Kidney stones | 0.37% | 1 in 272 | 1 million | more than 1 million cases (1996, NIDDK) |
| 282. Hemochromatosis | 0.37% | 1 in 272 | 1 million | more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK); 1-in-200 to 1-in-300 |
| 283. Parkinson's Disease | 0.37% | 1 in 272 | 1 million | 1 million people (unreliable estimate) |
| 284. Dog bite | 0.37% | 1 in 272 | 1 million | 1 million cases (unreliable estimate) |
| 285. Heritable Disorders of Connective Tissue | 0.37% | 1 in 272 | 1 million | estimated 1 million people in USA with heritable connective tissue disorder (NIAMS) |
| 286. Ankle injuries | 0.37% | 1 in 272 | 1 million | 1 million annually (NIAMS); 85% are ankle sprains. |
| 287. Hemochromatosis type 1 | 0.37% | 1 in 272 | 1 million | 1 million people suffer from hemochromatosis type 1 in the US, Genetics Home Reference website |
| 288. Accidental Eye Injury | 0.36% | 1 in 277 | 978,987 | 16,413 annual cases in Victoria 1996 (DHS-VIC) |
| 289. Selective IgA Deficiency | 0.33% | 1 in 300 | 906,666 | 1 in 300 (NIDCD); 1 in 600 (NIAID); 1 in 333 Caucasians. |
| 290. Multiple endocrine neoplasia type 2 | 0.33% | 1 in 300 | 906,666 | about 1 per 300 000 people suffer from multiple endocrine neoplasia type 1 in the US, Genetics Home Reference website |
| 291. Glutaricaciduria I | 0.33% | 1 in 300 | 906,666 | estimated 1 per 300 people from the Ojibwa population of Canada suffer from glutaric academia type I, Genetics Home Reference website |
| 292. HIV/AIDS | 0.33% | 1 in 302 | 900,000 | 900,000 Americans (NIAID, quarter are unaware) |
| 293. Ankle sprain | 0.31% | 1 in 320 | 850,000 | 850,000 annually (NIAMS) |
| 294. Interstitial cystitis | 0.31% | 1 in 321 | 847,000 | 847,000 in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003) |
| 295. Neuralgia | 0.30% | 1 in 333 | 816,000 | 3 per 1000 - NHIS95 (neuralgia or neuritis unspecified) |
| 296. Scoliosis | 0.30% | 1 in 333 | 816,000 | 3-per-1,000 to 5-per-1000 children (NIAMS) |
| 297. Variegate porphyria | 0.30% | 1 in 333 | 816,000 | approximately 3 per 1,000 white South Africans suffer from variegate porphyria, Genetics Home Reference website |
| 298. Gonorrhea | 0.29% | 1 in 339 | 800,000 | 800,000 cases (CDC estimate/NIAID) |
| 299. Chronic Hepatitis B | 0.28% | 1 in 362 | 750,000 | 750,000 people in the United States (NIAID) |
| 300. Gout | 0.28% | 1 in 363 | 748,000 | 275 per 100,000 people (NIAMS) |
| 301. Maple syrup urine disease | 0.26% | 1 in 384 | 706,493 | estimated 1 per 385 infants suffer from maple syrup urine disease in the Old Order Mennonite population, Genetics Home Reference website |
| 302. Spinal fracture | 0.26% | 1 in 388 | 700,000 | more than 700,000 spinal fractures annually in the USA (the number caused by osteoporosis) |
| 303. Poisoning | 0.26% | 1 in 391 | 694,829 | 11,649 annual cases in Victoria 1996 (DHS-VIC) |
| 304. Edentulism | 0.25% | 1 in 400 | 681,706 | 11,429 annual cases in Victoria 1996 (DHS-VIC) |
| 305. Acute Appendicitis | 0.25% | 1 in 400 | 680,000 | 25 per 10,000 (age 10-17), 1-2 per per 10,000 (under 4) |
| 306. Red-green color vision defects | 0.25% | 1 in 400 | 680,000 | estimated 0.5% of females of Northern European ancestry suffer from red-green color vision defects, Genetics Home Reference website |
| 307. Pulmonary embolism | 0.24% | 1 in 418 | 650,000 | approximately 650,000 cases annually in the USA |
| 308. Bacterial vaginosis | 0.24% | 1 in 424 | 640,000 | 16% of pregnant women (DSTD) |
| 309. Gall bladder conditions | 0.23% | 1 in 438 | 620,031 | 10,395 annual cases of gallbladder and bile duct disease in Victoria 1996 (DHS-VIC) |
| 310. Caesarian Section | 0.22% | 1 in 453 | 600,000 | more than 600,000 annually |
| 311. Polycystic kidney disease | 0.22% | 1 in 453 | 600,000 | 600,000 Americans |
| 312. Hysterectomy | 0.22% | 1 in 461 | 590,000 | 590,000 annually |
| 313. Inflammatory bowel disease | 0.20% | 1 in 500 | 544,000 | 1 in 500 (NIAID); 300,000 people to 500,000 people NIDDK |
| 314. Klinefelter syndrome | 0.20% | 1 in 500 | 544,000 | 1 per 500 - 1,000 males are affected by Klinefelter syndrome, Genetics Home Reference website |
| 315. Congenital hip dislocation | 0.20% | 1 in 500 | 544,000 | about 2 per 1000 births; up to 4 per 1000 |
| 316. Sickle Cell Anemia | 0.20% | 1 in 500 | 544,000 | estimated 1 per 1,000 Hispanic Americans are affected by sickle cell disease in the US, Genetics Home Reference website |
| 317. Autism | 0.20% | 1 in 500 | 544,000 | 1 in 500 to 1 in 2,500 (NIMH); 1-in-1000 to 2-in-1000, depending on diagnostic criteria |
| 318. Nonaffective Psychosis | 0.20% | 1 in 500 | 544,000 | estimated 0.2% adults (USSG) |
| 319. Somatization Disorder | 0.20% | 1 in 500 | 544,000 | estimated 0.2% adults (USSG) |
| 320. Postpartum psychosis | 0.20% | 1 in 500 | 544,000 | 1 in 500 to 1,000 new mothers |
| 321. Cerebral Palsy | 0.20% | 1 in 500 | 544,000 | 2 to 2.5 per 1,000 births (FMC) |
| 322. Traumatic Brain Injury | 0.20% | 1 in 500 | 544,000 | 0.2% of population has an acquired brain injury in Australia 1998 (Australia’s Health 2004, AIHW) |
| 323. Temporal arteritis | 0.20% | 1 in 500 | 544,000 | 200 per 100,000 people over 50. |
| 324. Intussusception | 0.20% | 1 in 500 | 544,000 | about 2 per 1000 cases in infants |
| 325. Hypertrophic cardiomyopathy | 0.20% | 1 in 500 | 544,000 | 0.2 percent of the U.S. population |
| 326. Sudden Infant Death Syndrome | 0.20% | 1 in 500 | 544,000 | 2 per 1,000 |
| 327. Gaucher disease type 1 | 0.20% | 1 in 500 | 544,000 | 1 per 500 - 1,000 people of Ashkenazi Jewish heritage are affected by type 1 Gaucher disease, Genetics Home Reference website |
| 328. Autosomal dominant polycystic kidney disease | 0.20% | 1 in 503 | 540,000 | 540,000 Americans approximately (90% of PKD) |
| 329. Hand fracture | 0.20% | 1 in 507 | 536,287 | 8,991 annual cases in Victoria 1996 (DHS-VIC) |
| 330. Crohn's disease | 0.18% | 1 in 544 | 500,000 | 500,000 Americans |
| 331. Chronic Fatigue Syndrome | 0.18% | 1 in 544 | 500,000 | 500,000 Americans (CDC/NIAID) |
| 332. Shingles | 0.18% | 1 in 544 | 500,000 | 500,000 cases (NIAID) |
| 333. Inguinal hernia | 0.18% | 1 in 544 | 500,000 | 500,000 cases (NIDDK) |
| 334. Pneumococcal pneumonia | 0.18% | 1 in 544 | 500,000 | 500,000 cases annually (NIAID) |
| 335. Bedsores | 0.17% | 1 in 573 | 474,692 | 474,692 new cases of decubitus ulcer occurred in the US 2000-2002 (Patient Safety in American Hospitals, Health Grades 2004) |
| 336. Viral Hepatitis | 0.17% | 1 in 601 | 452,000 | about 452,000 annual cases based on incidence of HepA, HepB, HepC, and HepD (NIDDK 1990-1992) |
| 337. Chronic Nonulcer dyspepsia | 0.16% | 1 in 612 | 444,000 | 444,000 new cases (1975/NIDDK) |
| 338. Premature Birth | 0.16% | 1 in 618 | 440,000 | 440,000 cases (unreliable estimate) |
| 339. Benign Prostate Hyperplasia | 0.16% | 1 in 627 | 433,216 | 7,263 annual cases in Victoria 1996 (DHS-VIC) |
| 340. Liver conditions | 0.15% | 1 in 679 | 400,000 | 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 341. Postpartum depression | 0.15% | 1 in 679 | 400,000 | 10% of pregnancies. |
| 342. Chronic liver disease | 0.15% | 1 in 679 | 400,000 | 400,000 people |
| 343. Cirrhosis of the liver | 0.15% | 1 in 679 | 400,000 | 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994) |
| 344. Ocular Herpes | 0.15% | 1 in 679 | 400,000 | 400,000 Americans have had some form |
| 345. Pernicious anemia | 0.15% | 1 in 680 | 399,454 | 399,455 people in the USA 1996 1 |
| 346. End-stage renal disease | 0.14% | 1 in 693 | 392,022 | 392,023 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003) |
| 347. Multiple Sclerosis | 0.14% | 1 in 700 | 388,571 | 1-in-700 (NIAID) |
| 348. Cleft palate | 0.14% | 1 in 700 | 388,571 | about 1 in 700 births |
| 349. Dementia | 0.14% | 1 in 738 | 368,320 | 6,175 annual cases in Victora 1996 (DHS-VIC) |
| 350. Intestinal obstruction | 0.13% | 1 in 746 | 364,563 | 6,112 annual cases in Victoria 1996 (DHS-VIC) |
| 351. Burns | 0.13% | 1 in 754 | 360,507 | 6,044 annual cases in Victora 1996 for fires/burns/scalds (DHS-VIC) |
| 352. Ankylosing Spondylitis | 0.13% | 1 in 775 | 350,879 | 129 of every 100,000 people in the US (Mayo Clinic) |
| 353. Type 1 diabetes | 0.12% | 1 in 800 | 340,000 | 1-in-800 (NIAID) |
| 354. Down Syndrome | 0.12% | 1 in 800 | 340,000 | 1-in-800 overall births |
| 355. Genital system cancer | 0.12% | 1 in 841 | 323,210 | 323,210 new cases for genital system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004) |
| 356. Neural tube defect | 0.12% | 1 in 864 | 314,703 | 11.57 per 10,000 births with neural tube defects in the UK 2002 (University of Ulster, 2003) |
| 357. Shoulder Fracture | 0.12% | 1 in 867 | 313,624 | 5,258 annual cases in Victoria 1996 of clavicle/scapula/humerus (DHS-VIC) |
| 358. Scleroderma | 0.11% | 1 in 906 | 300,000 | estimated 300,000 Americans (NWHIC) |
| 359. Hip fracture | 0.11% | 1 in 906 | 300,000 | more than 300,000 hip fractures annually (the number due to osteoporosis) |
| 360. Machinery accidents | 0.11% | 1 in 942 | 288,453 | 4,836 annual cases in Victoria 1996 (DHS-VIC) |
| 361. Kidney Dialysis | 0.11% | 1 in 946 | 287,493 | 287,494 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003) |
| 362. Natural accidents | 0.10% | 1 in 958 | 283,800 | 4,758 annual cases in Victoria 1996 of natural/environmental factors (DHS-VIC) |
| 363. Triple-X syndrome | 0.10% | 1 in 1,000 | 272,000 | 1 per 1,000 newborn girls suffer from triple X syndrome, Genetics Home Reference website |
| 364. Tourette Syndrome | 0.10% | 1 in 1,000 | 272,000 | estimated 1-10 per 1,000 children have Tourette syndrome, Genetics Home Reference website |
| 365. Anorexia Nervosa | 0.10% | 1 in 1,000 | 272,000 | estimated 0.1% adults (USSG); estimated 0.5 to 3.7 percent females (NIMH); 1% of adolescent girls (NWHIC) |
| 366. Wolf-Parkinson-White syndrome | 0.10% | 1 in 1,000 | 272,000 | 1-3 per 1,000 people suffer from Wolff-Parkinson-White syndrome worldwide, Genetics Home Reference website |
| 367. Clubfoot | 0.10% | 1 in 1,000 | 272,000 | about 1 per 1,000 births2. |
| 368. Noonan Syndrome | 0.10% | 1 in 1,000 | 272,000 | estimated 1 per 1,000 - 2,500 people are affected by Noonan syndrome, Genetics Home Reference website |
| 369. Ankle fracture | 0.10% | 1 in 1,048 | 259,524 | 4,351 annual cases in Victoria 1996 (DHS-VIC) |
| 370. Face fracture | 0.09% | 1 in 1,063 | 255,826 | 4,289 annual cases in Victoria 1996 (DHS-VIC) |
| 371. Digestive system cancer | 0.09% | 1 in 1,063 | 255,640 | 255,640 new cases for digestive system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004) |
| 372. Wrist fracture | 0.09% | 1 in 1,088 | 250,000 | at least 250,000 wrist fractures (the number caused by osteoporosis annually in the USA) |
| 373. Fractured femur | 0.09% | 1 in 1,155 | 235,486 | 3,948 annual cases in Victoria 1996 (DHS-VIC) |
| 374. Foot fracture | 0.08% | 1 in 1,240 | 219,262 | 3,676 annual cases in Victoria 1996 (DHS-VIC) |
| 375. Fractured Lower Leg | 0.08% | 1 in 1,304 | 208,466 | 3,495 annual cases in Victoria 1996 (DHS-VIC) |
| 376. Breast Cancer | 0.08% | 1 in 1,326 | 205,000 | 205,000 annual cases (SEER 2002 estimate); 180,000 annual cases (NCI); only about 1,000 men |
| 377. Von Hippel-Lindau Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 378. Zollinger-Ellison syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 379. Lichen sclerosis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 380. Immune Thrombocytopenic Purpura | 0.07% | 1 in 1,359 | 200,000 | rare. |
| 381. Behcet's Disease | 0.07% | 1 in 1,359 | 200,000 | rare in the USA; more common in Middle East, Asia, and Japan. |
| 382. Penile candidiasis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 383. Ascariasis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 384. Zellweger Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 385. Congenital SMA with arthrogryposis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 386. Agenesis of the corpus callosum | 0.07% | 1 in 1,359 | 200,000 | rare |
| 387. Aicardi syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 388. Empty Sella Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 389. Hydranencephaly | 0.07% | 1 in 1,359 | 200,000 | rare |
| 390. Klippel Feil Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 391. Mobius syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 392. Chediak-Higashi Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 393. Machado-Joseph Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 394. Kearns-Sayre Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 395. Alpers Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 396. Agnosia | 0.07% | 1 in 1,359 | 200,000 | rare |
| 397. Alexander Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 398. Alternating Hemiplegia | 0.07% | 1 in 1,359 | 200,000 | rare |
| 399. Binswanger's Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 400. Brown-Sequard Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 401. Fabry's Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 402. Fahr's Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 403. Hallervorden-Spatz disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 404. Joubert Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 405. Krabbé Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 406. Landau-Kleffner Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 407. Microcephaly | 0.07% | 1 in 1,359 | 200,000 | rare |
| 408. Miller Fisher Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 409. Moyamoya Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 410. Parry Romberg Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 411. Pelizaeus-Merzbacher Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 412. Primary Lateral Sclerosis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 413. Progressive Supranuclear Palsy | 0.07% | 1 in 1,359 | 200,000 | rare |
| 414. Rasmussen's Encephalitis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 415. Sandhoff Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 416. Schilder's Disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 417. Septo-Optic Dysplasia | 0.07% | 1 in 1,359 | 200,000 | rare |
| 418. Soto's Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 419. Stiff-Person Syndrome | 0.07% | 1 in 1,359 | 200,000 | rare |
| 420. Subacute Sclerosing Panencephalitis | 0.07% | 1 in 1,359 | 200,000 | rare - because of the rarity of measles due to vaccination programs. |
| 421. Ménétrier's disease | 0.07% | 1 in 1,359 | 200,000 | rare |
| 422. Goodpasture syndrome | 0.07% | 1 in 1,359 | 200,000 | rare. |
| 423. Encephaloceles | 0.07% | 1 in 1,359 | 200,000 | rare |
| 424. Ramsay Hunt Syndrome Type 2 | 0.07% | 1 in 1,359 | 200,000 | rare |
| 425. Narcolepsy | 0.07% | 1 in 1,359 | 200,000 | 200,000 Americans (NHLBI estimate); 50,000 diagnosed. |
| 426. Mastocytosis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 427. Cutaneous mastocytosis | 0.07% | 1 in 1,359 | 200,000 | rare |
| 428. Restrictive cardiomyopathy | 0.07% | 1 in 1,359 | 200,000 | rare |
| 429. Prostate Cancer | 0.07% | 1 in 1,439 | 189,000 | 189,000 annual cases in USA (SEER 2002 estimate); 168,665 new cases (NIDDK) |
| 430. Respiratory system cancer | 0.07% | 1 in 1,458 | 186,550 | 186,550 new cases for respiratory system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004) |
| 431. Norwalk-like viruses | 0.07% | 1 in 1,502 | 181,000 | estimated 181,000 cases annually in USA (CDC-OC) |
| 432. Aortic aneurysm | 0.07% | 1 in 1,537 | 176,913 | 2,966 annual cases in Victoria 1996 (DHS-VIC) |
| 433. Hydrocephalus | 0.06% | 1 in 1,547 | 175,711 | 6.46 per 10,000 births in the UK 2002 for hydrocephaly (University of Ulster, 2003) |
| 434. Lung cancer | 0.06% | 1 in 1,605 | 169,400 | 169,400 annual cases (SEER 2002 estimate: lung and bronchus cancers) |
| 435. Charcot-Marie-Tooth Disorder | 0.06% | 1 in 1,813 | 150,000 | 150,000 people are affected by Charcot-Marie-Tooth disease in the US, Genetics Home Reference website |
| 436. Adult respiratory distress syndrome | 0.06% | 1 in 1,813 | 150,000 | 150,000 adults (NHLBI) |
| 437. Colorectal cancer | 0.05% | 1 in 1,834 | 148,300 | 148,300 annual cases = 107,300 annual cases of colon cancer and 41,000 annual cases of rectum cancer(SEER 2002 estimate) |
| 438. Hepatorenal tyrosinemia | 0.05% | 1 in 1,845 | 147,345 | 1 per 1,846 people from the Saguenay-La St. Jean region of Quebec suffer from tyrosinemia type 1, Genetics Home Reference website |
| 439. Preeclampsia | 0.05% | 1 in 1,858 | 146,320 | 146,320 cases (1998/NHLBI); about 5% of pregnancies. |
| 440. Ménière's disease | 0.05% | 1 in 1,973 | 137,847 | about 10,000 people in Australia |
| 441. Jacobs syndrome | 0.05% | 1 in 2,000 | 136,000 | 1-in-2000 approximately. |
| 442. Keratoconus | 0.05% | 1 in 2,000 | 136,000 | 1-in-2000 Americans |
| 443. Brugada Syndrome | 0.05% | 1 in 2,000 | 136,000 | estimated 5 per 10,000 people suffer from Brugada syndrome worldwide, Genetic Home Reference website |
| 444. 47 XYY syndrome | 0.05% | 1 in 2,000 | 136,000 | 1 per 1,000 males are born with 47,XYY syndrome, Genetics Home Reference website |
| 445. Gestational diabetes | 0.05% | 1 in 2,014 | 135,000 | 135,000 pregnant women get the condition every year; 3-5% of pregnant women. |
| 446. Chickenpox | 0.04% | 1 in 2,254 | 120,624 | 120,624 annually (1995); 46,016 annual cases notified in USA 1999 (MMWR 1999); 199.14 per 100,000 in Canada 20003 |
| 447. Hip Replacement | 0.04% | 1 in 2,266 | 120,000 | 120,000 annually (NIAMS); 120,000 annual hip replacement operations in the USA. |
| 448. Whiplash | 0.04% | 1 in 2,266 | 120,000 | 120,000 annually |
| 449. Carbon monoxide poisoning | 0.04% | 1 in 2,400 | 113,333 | 25,000 annual cases of home exposure in the UK |
| 450. Turner Syndrome | 0.04% | 1 in 2,500 | 108,800 | 1 per 2,500 live female births are affected by Turner syndrome, Genetics Home Reference website |
| 451. Autoimmune Lymphoproliferative Syndrome | 0.04% | 1 in 2,719 | 100,000 | very rare; NIAID mentions 58 individuals |
| 452. Neonatal lupus | 0.04% | 1 in 2,719 | 100,000 | very rare |
| 453. Lyme disease | 0.04% | 1 in 2,719 | 100,000 | estimated 100,000 cases annually (NIAID/USA) |
| 454. Androgen Insensitivity Syndrome | 0.04% | 1 in 2,719 | 100,000 | very rare |
| 455. Porencephaly | 0.04% | 1 in 2,719 | 100,000 | extremely rare |
| 456. Schizencephaly | 0.04% | 1 in 2,719 | 100,000 | extremely rare |
| 457. Hyperparathyroidism | 0.04% | 1 in 2,719 | 100,000 | 100,000 cases per year in the USA |
| 458. Retinitis Pigmentosa | 0.04% | 1 in 2,719 | 100,000 | 100,000 people have retinitis pigmentosa which can cause retinal deterioration and blindness in the US (Research to Prevent Blindness, NISE, NSF) |
| 459. Urinary system cancer | 0.04% | 1 in 2,764 | 98,400 | 98,400 new cases for urinary system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004) |
| 460. Septicemia | 0.04% | 1 in 2,767 | 98,300 | 1,648 annual cases in Victora 1996 (DHS-VIC) |
| 461. Accidental death | 0.03% | 1 in 2,906 | 93,591 | 93,592 annual cases in 2000 (CDC); 97,860 annual cases in 1999 (NVSR Sep 2001) |
| 462. Edwards Syndrome | 0.03% | 1 in 3,000 | 90,666 | 1 per 5,000 - 6,000 newborns are affected by Trisomy 18, Genetics Home Reference website |
| 463. Velocardiofacial syndrome | 0.03% | 1 in 3,000 | 90,666 | 1-in-3000 approximately. |
| 464. Fragile-X Syndrome | 0.03% | 1 in 3,000 | 90,666 | approximately 1 per 8,000 females suffer from fragile X syndrome, Genetics Home Reference website |
| 465. Familial emphysema | 0.03% | 1 in 3,000 | 90,666 | 70,000 Americans |
| 466. Neurofibromatosis-1 | 0.03% | 1 in 3,000 | 90,666 | 1 per 3,000 - 4,000 people suffer from neurofibromatosis type 1 worldwide, Genetics Home Reference website |
| 467. Neurofibromatosis | 0.03% | 1 in 3,000 | 90,666 | about 1 in 30004. |
| 468. Congenital hypothyroidsim | 0.03% | 1 in 3,000 | 90,666 | 1 per 3,000 - 4,000 newborns are affected by congenital hypothyroidsim in North America, Europe, Japan and Australia, Genetics Home Reference website |
| 469. Suffocation | 0.03% | 1 in 3,285 | 82,790 | 1,388 annual cases in Victoria 1996 of suffocation and foreign bodies (DHS-VIC) |