Glossary for Machado-Joseph Disease

• Arm weakness: Weakness of one or both arms
• Ataxia: It is a neurological sign and symptom consisting of gross lack of co-ordination of muscle movements.
• Autosomal Dominant Genetic Diseases: Any conditions that are related to any non-sex-determining chromosome
• Autosomal Genetic Diseases: Any conditions that are related to any non-sex-determining chromosome
• Clumsiness: Clumsy motions or poor coordination
• Death: The cessation of life
• Dominant Genetic Diseases: Genetic disease where the mutated gene is dominant
• Genetic Disease: Any disease that is handed down to oneself through the chromosomes of ones parents
• Leg weakness: Muscle weakness of the leg
• Pneumonia: Infection of the lung by bacteria, viruses or fungus.
• Spasticity: Continuous contraction or stiffness of muscles.
• Spinocerebellar ataxia 2: A disorder involving degeneration of the brain and spinal cord and causing progressive coordination difficulty and other symptoms. Symptom generally become more severe earlier than in spinocerebellar ataxia 1.
• Spinocerebellar ataxia 3: A rare genetic disorder (chromosome 14q32.1defect) characterized by . Gait ataxia and dysarthria (speech disorder) also occur and are symptoms common to all the spinocerebellar ataxia types. The duration of the disease is 1-20 years.
• Staggering gait: When a patients gait is staggering in nature

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