What is Malignant hyperthermia?

What is Malignant hyperthermia?

• Malignant hyperthermia: A very rare genetic disorder where sufferers suffer episodes of adverse reactions when certain anesthetics or muscle relaxants are administered.
• Malignant hyperthermia: usually inherited reaction to general anesthesia manifested as a sudden, rapid rise in temperature, hypermetabolism, and skeletal muscle rigidity; mutation is in the calcium release channel of skeletal muscle sarcoplasmic reticulum.
  Source - Diseases Database
• Malignant hyperthermia: hereditary condition in which certain anesthetics (e.g., halothane) cause high body temperatures and muscle rigidity.
  Source - WordNet 2.1

Malignant hyperthermia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Malignant hyperthermia, or a subtype of Malignant hyperthermia, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Malignant hyperthermia as a "rare disease".
Source - Orphanet

Malignant hyperthermia: Introduction

How serious is Malignant hyperthermia?

Complications of Malignant hyperthermia: see complications of Malignant hyperthermia

What causes Malignant hyperthermia?

Causes of Malignant hyperthermia: see causes of Malignant hyperthermia

What are the symptoms of Malignant hyperthermia?

Symptoms of Malignant hyperthermia: see symptoms of Malignant hyperthermia

Complications of Malignant hyperthermia: see complications of Malignant hyperthermia

Malignant hyperthermia: Testing

Diagnostic testing: see tests for Malignant hyperthermia.

Misdiagnosis: see misdiagnosis and Malignant hyperthermia.

How is it treated?

Treatments for Malignant hyperthermia: see treatments for Malignant hyperthermia
Research for Malignant hyperthermia: see research for Malignant hyperthermia

Name and Aliases of Malignant hyperthermia

Main name of condition: Malignant hyperthermia

hyperthermia of anesthesia, malignant hyperpyrexia, fulminating hyperpyrexia, MH, Malignant fever, Pharmacogenic myopathy, Pharmacogenetic myopathy of anesthesia

Malignant hyperpyrexia, King-Denborough syndrome Source - Diseases Database

Fulminating hyperpyrexia, MH, Malignant fever, Malignant hyperpyrexia, Pharmacogenic myopathy
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Research the causes of these diseases that are similar to, or related to, Malignant hyperthermia:

• General anaesthetics
• Succinylcholine
• Rhabdomyolysis
• Hypercapnia
• Hyperthermia
• Electrolyte imbalance
• Dantrolene sodium

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