Mastocytosis

Introduction: Mastocytosis

Mastocytosis: Mastocytosis is a group of disorders in both children and adults caused by the presence of too many mast cells in a person's body. Located in skin, the ... more about Mastocytosis.

Mastocytosis: A disorder where excessive amounts of mast cells proliferate in organs such as the skin, liver, bone, spleen and gastrointestinal tract. Mast cells occur in connective tissue and defend the body against disease by releasing histamine to stimulate the immune system. More detailed information about the symptoms, causes, and treatments of Mastocytosis is available below.

Symptoms of Mastocytosis

• Itching
• Bone pain
• Muscle pain
• Abdominal discomfort
• Nausea

See full list of 33 symptoms of Mastocytosis

Medical Textbooks Online about Mastocytosis

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Wrongly Diagnosed with Mastocytosis?

• Underlying causes of Mastocytosis (possibly wrongly diagnosed)

Causes of Mastocytosis

• Cancer
• Blood disorders

Read more about causes of Mastocytosis

More information about causes of Mastocytosis:

• Underlying causes of Mastocytosis

Videos for Mastocytosis

Patient Surveys for Mastocytosis

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Reseach about Mastocytosis

Visit our research pages for current research about Mastocytosis treatments.

Clinical Trials for Mastocytosis

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Mastocytosis include:

• Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes - This study is currently recruiting patients (Current: 23 Nov 2006) - imatinib mesylate
• A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Blood Related Cancers - This study is currently recruiting patients (Current: 23 Nov 2006) - AMN107
• Phase II PKC412 in Aggressive Systemic Mastocytosis and Mast Cell Leukemia - This study is currently recruiting patients (Current: 23 Nov 2006) - PKC 412
• Study of Factors Regulating Mast Cell Proliferation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Mast Cell Precursors - This study is currently recruiting patients (Current: 23 Nov 2006)

See full list of 15 Clinical Trials for Mastocytosis

Statistics for Mastocytosis

• Medical statistics for Mastocytosis
• Prevalence and incidence statistics for Mastocytosis
• Death and Mortality statistics for Mastocytosis
• Society statistics for Mastocytosis

Types of Mastocytosis

• Cutaneous mastocytosis
• Systemic mastocytosis
• Diffuse mastrocytosis
• Mastocytoma
• Urticaria pigmentosa

See full list of 6 Types of Mastocytosis

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Article Excerpts about Mastocytosis

Mastocytosis is a group of disorders in both children and adults caused by the presence of too many mast cells in a person's body. Located in skin, the linings of the stomach and intestine, as well as other sites, mast cells may play an important role in helping defend these tissues from disease. By releasing chemical "alarms" such as histamine, mast cells attract other key players of the immune defense system to areas of the body where they are needed. (Source: excerpt from Mastocytosis, NIAID Fact Sheet: NIAID)

Definitions of Mastocytosis:

A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems. Recent data suggest that most variants of mastocytosis are clonal disorders. (WHO, 2001) -- 2003 - (Source - Diseases Database)

Mastocytosis is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Mastocytosis, or a subtype of Mastocytosis, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)