The list of signs and symptoms mentioned in various sources for Methotrexate toxicity includes the 11 symptoms listed below:
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Depending on poison (such as alcohol, cyanide, acetone, turpentine, or petroleum): headache, seizures, loss of consciousness, chest pain, muscle weakness, dizziness, nausea, vomiting
Source: Professional Guide to Diseases (Eighth Edition), 2005
Pain, edema, fever, skin discoloration, petechiae, ecchymoses, blebs, blisters, bloody wound discharge, necrosis
Source: Professional Guide to Diseases (Eighth Edition), 2005
Most snakebites happen on the arms and legs, below the elbow or knee. Bites to the head or trunk are most dangerous, but any bite into a blood vessel is dangerous, regardless of location.
Most pit viper bites that result in envenomation cause immediate and progressively severe pain and edema, local elevation in skin temperature, fever, skin discoloration, petechiae, ecchymoses, blebs, blisters, bloody wound discharge, and local necrosis. (See After a snakebite.)
Because pit viper venom is neurotoxic, pit viper bites may cause local and facial numbness and tingling, fasciculation and twitching of skeletal muscles, seizures (especially in children), extreme anxiety, difficulty speaking, fainting, weakness, dizziness, excessive sweating, occasional paralysis, mild to severe respiratory distress, headache, blurred vision, marked thirst and, in severe envenomation, coma and death. Pit viper venom may also impair coagulation and cause hematemesis, hematuria, melena, bleeding gums, and internal bleeding. Other symptoms of pit viper bites include tachycardia, lymphadenopathy, nausea, vomiting, diarrhea, hypotension, and shock.
The reaction to coral snakebite is usually delayed — sometimes up to several hours. These snakebites cause little or no local tissue reaction (local pain, swelling, or necrosis). However, because coral snake venom is neurotoxic, a reaction can progress swiftly, producing such effects as local paresthesia, drowsiness, nausea, vomiting, difficulty swallowing, marked salivation, dysphonia, ptosis, blurred vision, miosis, respiratory distress and possible respiratory failure, loss of muscle coordination and, possibly, shock with cardiovascular collapse and death.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Most snakebites happen on the arms and legs, below the elbow or knee. Bites to the head or trunk are most dangerous, but any bite into a blood vessel is dangerous, regardless of location.
Most pit viper bites that result in envenomation cause immediate and progressively severe pain and edema (the entire extremity may swell within a few hours), local elevation in skin temperature, fever, skin discoloration, petechiae, ecchymoses, blebs, blisters, bloody wound discharge, and local necrosis.
Because pit viper venom is neurotoxic, pit viper bites may cause local and facial numbness and tingling, fasciculation and twitching of skeletal muscles, seizures (especially in children), extreme anxiety, difficulty speaking, fainting, weakness, dizziness, excessive sweating, occasional paralysis, mild to severe respiratory distress, headache, blurred vision, marked thirst and, in severe envenomation, coma and death. Pit viper venom may also impair coagulation and cause hema-temesis, hematuria, melena, bleeding gums, and internal bleeding. Other symptoms of pit viper bites include tachycardia, lymphadenopathy, nausea, vomiting, diarrhea, hypotension, and shock.
The reaction to coral snakebite is usually delayed — sometimes up to several hours. These snakebites cause little or no local tissue reaction (local pain, swelling, or necrosis). However, because coral snake venom is neurotoxic, a reaction can progress swiftly, producing such effects as local paresthesia, drowsiness, nausea, vomiting, difficulty swallowing, marked salivation, dysphonia, ptosis, blurred vision, miosis, respiratory distress and possible respiratory failure, loss of muscle coordination and, possibly, shock with cardiovascular collapse and death.
Source: Handbook of Diseases, 2003
These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:
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The symptom information on this page attempts to provide a list of some possible signs and symptoms of Methotrexate toxicity. This signs and symptoms information for Methotrexate toxicity has been gathered from various sources, may not be fully accurate, and may not be the full list of Methotrexate toxicity signs or Methotrexate toxicity symptoms. Furthermore, signs and symptoms of Methotrexate toxicity may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Methotrexate toxicity symptoms.
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