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Investigating symptoms of pituitary tumor, hypoglycemia, hypercalcemia, or GI hemorrhage may lead to a diagnosis of MEN. Diagnostic tests must be used to carefully evaluate each affected endocrine gland. For example, radioimmunoassay showing increased levels of gastrin in patients with peptic ulceration and Zollinger-Ellison syndrome suggests the need for follow-up studies for MEN I because 50% of patients with Zollinger-Ellison syndrome have MEN. After confirmation of MEN, family members must also be assessed for this inherited syndrome.
Magnetic resonance imaging or computed tomography scan of the abdomen may show pancreatic tumor. Insulin test may show increased levels and fasting blood sugar may be low.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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