The list of signs and symptoms mentioned in various sources for Multiple endocrine neoplasia includes the 15 symptoms listed below:
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Clinical effects of MEN may develop in various combinations and orders, depending on the glands involved. The most common manifestation of MEN I is hyperparathyroidism, followed by ulcer due to Zollinger-Ellison syndrome (marked by increased gastrin production from non-beta islet cell tumors of the pancreas). Hypoglycemia may result from pancreatic beta islet cell tumors, with increased insulin production. When MEN I affects the parathyroids, it produces signs of hyperparathyroidism, including hypercalcemia (because the parathyroids are primarily responsible for the regulation of calcium and phosphorus levels). When MEN causes pituitary tumor, it’s most commonly a prolactinoma, but can be a growth hormone or corticotropin, or even a nonsecretory adenoma.
Characteristic features of MEN II with medullary carcinoma of the thyroid include enlarged thyroid mass, with resultant increased calcitonin and, occasionally, ectopic corticotropin, causing Cushing’s syndrome. With tumors of the adrenal medulla, symptoms include headache, tachyarrhythmias, and hypertension; with adenomatosis or hyperplasia of the parathyroids, symptoms result from renal calculi.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Multiple endocrine neoplasia (MEN) is a group of rare diseases caused by genetic defects that lead to hyperplasia (abnormal multiplication or increase in the number of normal cells in normal arrangement in a tissue) and hyperfunction (excessive functioning) of two or more components of the endocrine system. (Source: Genes and Disease by the National Center for Biotechnology)
When these glands go into overdrive, the result can be: excessive calcium in the bloodstream (resulting in kidney stones or kidney damage); fatigue; weakness; muscle or bone pain; constipation; indigestion; and thinning of bones. (Source: Genes and Disease by the National Center for Biotechnology)
These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:
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The symptom information on this page attempts to provide a list of some possible signs and symptoms of Multiple endocrine neoplasia. This signs and symptoms information for Multiple endocrine neoplasia has been gathered from various sources, may not be fully accurate, and may not be the full list of Multiple endocrine neoplasia signs or Multiple endocrine neoplasia symptoms. Furthermore, signs and symptoms of Multiple endocrine neoplasia may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Multiple endocrine neoplasia symptoms.
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