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Treatment must eradicate the tumors. Subsequent therapy controls residual symptoms. In MEN I, peptic ulceration is usually the most urgent clinical feature, so primary treatment emphasizes control of bleeding or resection of necrotic tissue. In hypoglycemia caused by insulinoma, oral administration of diazoxide or glucose can keep blood glucose levels within acceptable limits. Subtotal (partial) pancreatectomy is required to remove the tumor. Because all parathyroid glands have the potential for neoplastic enlargement, subtotal parathyroidectomy may also be required along with transsphenoidal hypophysectomy. In MEN II, treatment of an adrenal medullary tumor includes antihypertensives and resection of the tumor. Bromocriptine may be used for pituitary tumors that secrete prolactin. Hormonal replacement therapy is necessary when glands are removed or secretion is inadequate.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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