Alexander Disease

Introduction: Alexander Disease

Description of Alexander Disease

Alexander Disease (medical condition): Brain myelin disorder causing mental degeneration.

See also:

Alexander Syndrome:
  »Introduction: Alexander Syndrome
  »Symptoms of Alexander Syndrome
  »Treatments for Alexander Syndrome

Alexander Disease: [MIM*203450] a rare, fatal degenerative disease of the central nervous system of infants, characterized by psychomotor retardation, seizures, and paralysis; megaloencephaly is associated with widespread leukodystrophic changes, especially in the frontal lobes.
Source: Stedman's Medical Spellchecker, © 2006 Lippincott Williams & Wilkins. All rights reserved.

Alexander Disease: A rare inherited disorder of myelin formation. Alexander disease is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal, subpial, and periventricular areas of the BRAIN.
Source: Diseases Database

Alexander Disease: A rare inherited disorder of myelin formation. Alexander disease is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal, subpial, and periventricular areas of the BRAIN.
Source: MeSH 2007

Alexander Disease: Rare Disease

Ophanet

Ophanet, a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Alexander Disease as a "rare disease".

Source - Orphanet

Alexander Disease as a Disease

Alexander Disease: Another name for Alexander Syndrome (or close medical condition association).
  »Introduction: Alexander Syndrome
  »Symptoms of Alexander Syndrome
  »Treatments for Alexander Syndrome

Alexander Disease: Related Diseases

Alexander Disease: Alexander Disease is listed as a type of (or associated with) the following medical conditions in our database:

• Leukodystrophy
• Brain conditions
• Genetic Disease
• Spinal Cord Disorders

Symptoms of Alexander Disease (Alexander Syndrome)

Some of the symptoms of Alexander Disease incude:

• Mental retardation
• Physical retardation
• Dementia
• Brain enlargement
• Head enlargement

See full list of 23 symptoms of Alexander Disease (Alexander Syndrome)

Treatments for Alexander Disease (Alexander Syndrome)

Treatments for Alexander Disease (Alexander Syndrome) include:

• Symptomatic and supportive treatments

Read more about treatments for Alexander Disease

Treatment of Alexander Disease: For more treatment information about Alexander Disease, see treatment of Alexander Syndrome (Alexander Disease)

Alexander Disease: Article Excerpts about Alexander Syndrome

Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath — the fatty covering which acts as an insulator — on nerve fibers in the brain. (Source: excerpt from NINDS Alexander Disease Information Page: NINDS)

Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath — the fatty covering which acts as an insulator — on nerve fibers in the brain. (Source: excerpt from NINDS Alexander Disease Information Page: NINDS)

Terms associated with Alexander Disease:

Terms Similar to Alexander Disease:

• Fibrinoid leukodystrophy

Source: Diseases Database

Broader terms for Alexander Disease

• Hereditary Central Nervous System Demyelinating Diseases
• Heredodegenerative Disorders, Nervous System

Source - MeSH 2007

Hierarchical classifications of Alexander Disease

The following list attempts to classify Alexander Disease into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Nervous System Diseases
  • Demyelinating Diseases
    • Hereditary Central Nervous System Demyelinating Diseases
      • Alexander Disease

MeSH 2007 Hierarchy

• Nervous System Diseases
  • Neurodegenerative Diseases
    • Heredodegenerative Disorders, Nervous System
      • Alexander Disease

MeSH 2007 Hierarchy

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities
  • Genetic Diseases, Inborn
    • Heredodegenerative Disorders, Nervous System
      • Alexander Disease

External links related to: Alexander Disease

• Search Jablonski's Syndromes Database
• Alexander disease
• Alexander Disease - MedPix™ Medical Image Database and Teaching Files
• OMIM - ALEXANDER DISEASE
• Alexander disease - Genetics Home Reference
• GeneReviews: Alexander Disease
• Alexander's disease - MedPix™ Medical Image Database and Teaching Files
• Alexander's disease - MedPix™ Medical Image Database and Teaching Files

Source: Diseases Database

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