Amifostine: A phosphorylated aminosulfhydryl compound. After dephosphorylation by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, amifostine binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. (NCI04)
Source: Diseases Database
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Source: MeSH 2007
Source - MeSH 2007
Source - MeSH 2007
The following list attempts to classify Amifostine into categories where each line is subset of the next.
Source: Diseases Database
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