Amsacrine

Introduction: Amsacrine

Description of Amsacrine

Amsacrine (medical condition): Some evidence indicates that exposure to Amsacrine has a possible link to an increased risk of developing cancer in humans. The carcinogenicity of the substance may be influenced by the duration and level of exposure. Amsacrine is used primarily as a chemotherapy drug to treat leukemia.

See also:

Possible human carcinogenic exposure - Amsacrine:
  »Introduction: Possible human carcinogenic exposure - Amsacrine
  »Symptoms of Possible human carcinogenic exposure - Amsacrine

Amsacrine: An aminoacridine derivative with potent antineoplastic properties. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. (NCI04)
Source: Diseases Database

Amsacrine: Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Source: MeSH 2007

Amsacrine as a Disease

Amsacrine: Another name for Possible human carcinogenic exposure - Amsacrine (or close medical condition association).
  »Introduction: Possible human carcinogenic exposure - Amsacrine
  »Symptoms of Possible human carcinogenic exposure - Amsacrine

Symptoms of Amsacrine (Possible human carcinogenic exposure - Amsacrine)

Some of the symptoms of Amsacrine incude:

• Increased risk of cancer

Read more about symptoms of Amsacrine (Possible human carcinogenic exposure - Amsacrine)

Terms associated with Amsacrine:

Terms Similar to Amsacrine:

• m-AMSA

Source - MeSH 2007

Broader terms for Amsacrine

• Aminoacridines

Source - MeSH 2007

Hierarchical classifications of Amsacrine

The following list attempts to classify Amsacrine into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Heterocyclic Compounds
  • Heterocyclic Compounds, 3-Ring
    • Acridines
      • Aminoacridines
        • Amsacrine

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