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Atazanavir sulfate: A synthetic antiviral agent. As a symmetric azapeptide agent structurally different from other HIV protease inhibitors, atazanavir selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. This agent does not elevate serum lipids, a common problem with other protease inhibitors. (NCI04)
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