Docetaxel

Introduction: Docetaxel

Description of Docetaxel

Docetaxel: A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)
Source: Diseases Database

Terms associated with Docetaxel:

Terms Similar to Docetaxel:

• Docetaxol

Source: Diseases Database

The following terms can be used for Docetaxel

• paclitaxel

Source: CRISP

External links related to: Docetaxel

• Taxanes in Cancer Treatment
• Second-line chemotherapy for non-small cell lung cancer (Cochrane Review)
• Taxotere 20mg and 80mg concentrate and solvent for infusion , SPC from the eMC
• Breast cancer - taxanes - review (No. 30)
• Lung cancer - docetaxel, paclitaxel, gemcitabine and vinorelbine (No. 26) - obsolete, updated by and incorporated into the guideline on the diagnosis and treatment of lung cancer (CG24)
• Taxane containing regimens for metastatic breast cancer (Cochrane Review)
• Taxotere Online, Description, Chemistry, Ingredients - Docetaxel - RxList Monographs
• CancerSourceMD.Com Drug Guide
• RxMed: Pharmaceutical Information - TAXOTERE

Source: Diseases Database

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