Mucopolysaccharidosis II (medical condition): Disorder of mucopolysaccharide metabolism in juveniles.
See also:
Mucopolysaccharidosis II:
»Introduction: Mucopolysaccharidosis II
»Symptoms of Mucopolysaccharidosis II
»Treatments for Mucopolysaccharidosis II
Mucopolysaccharidosis II: An inborn mucopolysaccharide metabolism disorder with iduronate-2-sulfatase deficiency. Clinical characteristics are similar to those in MPS I, except for the absence of corneal clouding and slower progression of the course of disease and central nervous system deterioration. Retinal degeneration may occur, but the cornea usually remains clear. Appearance is normal at birth with excessive growth taking place during first two years of life. Two types are recognized: A severe form (MPS IIA) which is characterized mainly by mental retardation and progressive physical deterioration and early death, and a mild form (MPS IIB) in which patients may survive into adulthood. MPS IIA usually occurs between 2 and 4 years of age with progressive deterioration, chronic diarrhea, recurrent ear infections, hearing impairment, communicating hydrocephalus with increased intracranial pressure, and death at about 10 and 15 years. Obstructive airway disease, cardiac valvular dysfunction, myocardial thickening, pulmonary hypertension, coronary disease, and myocardial infarction may be superimposed. MPS IIB is milder with preservation of intelligence. The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema. Death may occur in early adulthood, usually from airway obstruction or cardiac failure.
Source: Diseases Database
Mucopolysaccharidosis II: Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.
Source: MeSH 2007
These medical condition or symptom topics may be relevant to medical information for Mucopolysaccharidosis II:
Mucopolysaccharidosis II is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Mucopolysaccharidosis II, or a subtype of Mucopolysaccharidosis II,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Mucopolysaccharidosis II (medical condition): See Mucopolysaccharidosis II (disease information).
»Introduction: Mucopolysaccharidosis II
»Symptoms of Mucopolysaccharidosis II
»Treatments for Mucopolysaccharidosis II
Mucopolysaccharidosis II: Mucopolysaccharidosis II is listed as a type of (or associated with) the following medical conditions in our database:
MPS II, also called Hunter syndrome, affects juveniles and includes a mild and a severe form. Signs of the severe form are joint stiffness, mental deterioration, dwarfing, and progressive deafness. Death usually occurs by age 15. Symptoms of the mild form include short stature, limitation of motion, and features such as an enlarged forehead, lips, and tongue and misaligned teeth. (Source: excerpt from NINDS Mucopolysaccharidoses Information Page: NINDS)
MPS II, also called Hunter syndrome, affects juveniles and includes a mild and a severe form. Signs of the severe form are joint stiffness, mental deterioration, dwarfing, and progressive deafness. Death usually occurs by age 15. Symptoms of the mild form include short stature, limitation of motion, and features such as an enlarged forehead, lips, and tongue and misaligned teeth. (Source: excerpt from NINDS Mucopolysaccharidoses Information Page: NINDS)
These medical disease topics may be related to Mucopolysaccharidosis II:
Source: Diseases Database
Source - NIH
Source - MeSH 2007
Source - MeSH 2007
Source - MeSH 2007
The following list attempts to classify Mucopolysaccharidosis II into categories where each line is subset of the next.
Source: Diseases Database
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