Myelodysplastic syndrome

Introduction: Myelodysplastic syndrome

Description of Myelodysplastic syndrome

Myelodysplastic syndrome (medical condition): A group of syndromes characterized by a disruption in the production of blood cells. Often the bone marrow increases production of various blood cells but because many of them are defective, they are destroyed before the reach the blood stream. See also Myelodysplastic syndromes:
  »Introduction: Myelodysplastic syndromes
  »Symptoms of Myelodysplastic syndromes

Myelodysplastic syndrome: a heterogeneous group of clonal hematopoietic stem cell disorders characterized by the presence of dysplastic changes in one or more of hematopoietic lineages. The common clinical picture may include anemia, infections, and bleeding problems. Occurs generally in elderly patients, or those with prior exposure to leukemogenic agents. Transformation rates to acute leukemia range from 10-80%. Cytogenetic abnormalities are associated with a poor prognosis. SYN: preleukemia, smoldering leukemia.
Source: Stedman's Medical Spellchecker, © 2006 Lippincott Williams & Wilkins. All rights reserved.

Myelodysplastic syndrome: Disease in which the bone marrow does not function normally. Also called preleukemia or smoldering leukemia.
Source: National Institute of Health

Myelodysplastic syndrome: A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series. Refractory anemia is uncommon. It is primarily a disease of older adults. The median survival exceeds 5 years. (WHO, 2001) -- 2003
Source: Diseases Database

Myelodysplastic syndrome: Conditions in which the bone marrow shows qualitative and quantitative changes suggestive of a preleukemic process, but having a chronic course that does not necessarily terminate as acute leukemia.
Source: MeSH 2007

Myelodysplastic syndrome: Rare Disease

Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Myelodysplastic syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Myelodysplastic syndrome, or a subtype of Myelodysplastic syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet

Ophanet, a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Myelodysplastic syndrome as a "rare disease".

Source - Orphanet

Myelodysplastic syndrome as a Disease

Myelodysplastic syndrome: Another name for Myelodysplastic syndromes (or close medical condition association).
  »Introduction: Myelodysplastic syndromes
  »Symptoms of Myelodysplastic syndromes

Myelodysplastic syndrome: Myelodysplastic syndrome is listed as a type of (or associated with) the following medical conditions in our database: Bone Marrow Conditions

Symptoms of Myelodysplastic syndrome (Myelodysplastic syndromes)

Some of the symptoms of Myelodysplastic syndrome incude:

• Fatigue
• Lightheadedness
• Fever
• Bruising
• Splenomegaly

See full list of 26 symptoms of Myelodysplastic syndrome (Myelodysplastic syndromes)

Terms associated with Myelodysplastic syndrome:

Terms Similar to Myelodysplastic syndrome:

• Dysmyelopoietic syndrome
• Preleukemia syndrome
• Refractory anaemia

Source: Diseases Database

• MDS (Myelodysplastic syndromes)

Source - NIH

• Dysmyelopoietic Syndromes

Source - MeSH 2007

More specific terms for Myelodysplastic syndrome:

• Anemia, Refractory
• Anemia, Sideroblastic
• Hemoglobinuria, Paroxysmal
• Leukemia, Myeloid

Source - MeSH 2007

Broader terms for Myelodysplastic syndrome

• Bone Marrow Diseases

Source - MeSH 2007

Hierarchical classifications of Myelodysplastic syndrome

The following list attempts to classify Myelodysplastic syndrome into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Hemic and Lymphatic Diseases
  • Hematologic Diseases
    • Bone Marrow Diseases
      • Myelodysplastic Syndromes

External links related to: Myelodysplastic syndrome

• eMedicine - Myelodysplastic Syndrome : Article by Glenda H Grawe, MD
• New WHO classification of malignant hematological diseases
• National Cancer Institute - Myelodysplastic Syndromes Treatment
• eMedicine - Myelodysplastic Syndrome : Article by Emmanuel C Besa, MD
• eMedicine - Myelodysplasia : Article by Sharon M Castellino, MD, FAAP

Source: Diseases Database

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