Sulindac

Introduction: Sulindac

Description of Sulindac

Sulindac: a nonsteroidal anti-inflammatory drug (trade name Clinoril).
Source: WordNet 2.1

Sulindac: A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
Source: Diseases Database

Sulindac: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Source: MeSH 2007

Terms associated with Sulindac:

Terms Similar to Sulindac:

• Clinoril

Source - WordNet 2.1

Broader terms for Sulindac

• Indenes

Source - MeSH 2007

• nonsteroidal anti-inflammatory
• nonsteroidal anti-inflammatory drug
• NSAID

Source - WordNet 2.1

Hierarchical classifications of Sulindac

The following list attempts to classify Sulindac into categories where each line is subset of the next.

WordNet 2.1

• nonsteroidal anti-inflammatory,nonsteroidal anti-inflammatory drug,NSAID
• anti-inflammatory,anti-inflammatory drug
• medicament,medication,medicinal drug,medicine
• drug
• agent
• causal agency,causal agent,cause
• entity

Source: WordNet 2.1

MeSH 2007 Hierarchy:

• Organic Chemicals
  • Hydrocarbons
    • Hydrocarbons, Cyclic
      • Hydrocarbons, Aromatic
        • Polycyclic Hydrocarbons, Aromatic
          • Indenes
            • Sulindac

MeSH 2007 Hierarchy

• Polycyclic Compounds
  • Polycyclic Hydrocarbons, Aromatic
    • Indenes
      • Sulindac

External links related to: Sulindac

• eMedicine - Toxicity, Nonsteroidal Anti-inflammatory Agents : Article by Carlyn Ko, MD
• Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee (Cochrane Review)
• Clinoril Online, Description, Chemistry, Ingredients - Sulindac - RxList Monographs

Source: Diseases Database

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