Suramin

Introduction: Suramin

Description of Suramin

Suramin: A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.(NCI04)
Source: Diseases Database

Suramin: naphthalenesulfonate antitrypanosomal and antifilarial agent; also suppresses adrenocortical cells and is used in treatment of adrenocortical cancer.
Source: CRISP

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Source: MeSH 2007

Terms associated with Suramin:

Broader terms for Suramin

• Naphthalenesulfonates

Source - MeSH 2007

• antiprotozoal agent
• carbopolycyclic compound

Source - CRISP

Hierarchical classifications of Suramin

The following list attempts to classify Suramin into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Organic Chemicals
  • Hydrocarbons
    • Hydrocarbons, Cyclic
      • Hydrocarbons, Aromatic
        • Polycyclic Hydrocarbons, Aromatic
          • Naphthalenes
            • Naphthalenesulfonates
              • Suramin

MeSH 2007 Hierarchy

• Organic Chemicals
  • Sulfur Compounds
    • Sulfur Acids
      • Sulfonic Acids
        • Arylsulfonic Acids
          • Arylsulfonates
            • Naphthalenesulfonates
              • Suramin

MeSH 2007 Hierarchy

• Polycyclic Compounds
  • Polycyclic Hydrocarbons, Aromatic
    • Naphthalenes
      • Naphthalenesulfonates
        • Suramin

External links related to: Suramin

• Centers for Disease Control and Prevention: National Center for Infectious Diseases - Scientific Resources Program (SRP)
• MedDet

Source: Diseases Database

Interesting Medical Articles:

• Symptoms of the Silent Killer Diseases
• Online Diagnosis
• Self Diagnosis Pitfalls
• Pitfalls of Online Diagnosis
• Research Your Symptoms
• Diseases & Medical Conditions
• Medical Diagnosis
• [Full list of premium articles on symptoms, diseases, and diagnosis]

Medical dictionaries:

• Medical dictionary,
• Medical Acronymns/Abbreviations

More Medical Dictionary Topics

T-E fistula

Find out more

Search to find out more about Suramin:

powered by Search the Web Search wrongdiagnosis.com

 » Next page: Surdocardiac syndrome

Rate This Website

What do you think about the features of this website? Take our user survey and have your say:

Website User Survey

Medical Tools & Articles:

Tools & Services:

• Bookmark this page
• Symptom Search
• Symptom Checker
• Medical Dictionary
• Give your feedback

Medical Articles:

• Disease & Treatments Search
• Misdiagnosis Center
• Full list of interesting articles

Forums & Message Boards

• Ask or answer a question at the Boards:
• I cannot get a diagnosis. Please help.
• Tell us your medical story.
• Share your misdiagnosis story.
• What is the best treatment for my condition?
• See all the Boards.

Enter your search terms Submit search form
Search The Web Search wrongdiagnosis.com

Common Health Mistakes

Symptom
Checker

Search Specialists by State and City