The list of signs and symptoms mentioned in various sources for N syndrome includes the 46 symptoms listed below:
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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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Signs of acute leukemia are sudden onset of high fever accompanied by thrombocytopenia and abnormal bleeding, such as nosebleeds, gingival bleeding, purpura, ecchymoses, petechiae, easy bruising after minor trauma, and prolonged menses. Nonspecific signs and symptoms, such as low-grade fever, weakness, and lassitude, may persist for days or months before visible symptoms appear. Other insidious signs and symptoms include pallor, chills, and recurrent infections. In addition, ALL, AML, and acute monoblastic leukemia may cause dyspnea, anemia, fatigue, malaise, tachycardia, palpitations, systolic ejection murmur, and abdominal or bone pain. When leukemic cells cross the blood-brain barrier and thereby escape the effects of systemic chemotherapy, the patient may develop meningeal leukemia (confusion, lethargy, headache).
Source: Professional Guide to Diseases (Eighth Edition), 2005
CLL is the most benign and the most slowly progressive form of leukemia. Clinical signs derive from the infiltration of leukemic cells in bone marrow, lymphoid tissue, and organ systems.
In early stages, patients usually complain of fatigue, malaise, fever, and nodal enlargement. They're particularly susceptible to infection.
In advanced stages, patients may experience severe fatigue and weight loss, with liver or spleen enlargement, bone tenderness, and edema from lymph node obstruction. Pulmonary infiltrates may appear when lung parenchyma is involved. Skin infiltrations, manifested by macular to nodular eruptions, occur in about one-half of the cases of CLL.
As the disease progresses, bone marrow involvement may lead to anemia, pallor, weakness, dyspnea, tachycardia, palpitations, bleeding, and infection. Opportunistic fungal, viral, and bacterial infections commonly occur in late stages.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Signs and symptoms of acute leukemia are the sudden onset of high fever accompanied by thrombocytopenia and abnormal bleeding, such as nosebleeds, gingival bleeding, purpura, ecchymoses, petechiae, easy bruising after minor trauma, and prolonged menses. Nonspecific signs and symptoms — such as low-grade fever, weakness, and lassitude — may persist for days or months before visible signs appear.
Other insidious signs and symptoms include pallor, chills, and recurrent infections. In addition, ALL, AML, and acute monoblastic leukemia may cause dyspnea, anemia, fatigue, malaise, tachycardia, palpitations, systolic ejection murmur, and abdominal or bone pain. When leukemic cells cross the blood-brain barrier and thereby escape the effects of systemic chemotherapy, the patient may develop meningeal leukemia, characterized by confusion, lethargy, and headache.
Source: Handbook of Diseases, 2003
Chronic lymphocytic leukemia is the most benign and the most slowly progressive form of leukemia. Signs and symptoms derive from the infiltration of leukemic cells in bone marrow, lymphoid tissue, and organ systems.
In early stages, patients usually complain of fatigue, malaise, fever, and nodal enlargement. They’re particularly susceptible to infection, which may be fatal.
In advanced stages, patients may experience severe fatigue and weight loss, with liver or spleen enlargement, bone tenderness, and edema from lymph node obstruction. Pulmonary infiltrates may appear when lung parenchyma is involved. Skin infiltrations, manifested by macular to nodular eruptions, occur in about one-half of the cases of chronic lymphocytic leukemia.
As the disease progresses, bone marrow involvement may lead to anemia, pallor, weakness, dyspnea, tachycardia, palpitations, bleeding, or infection. Opportunistic fungal, viral, and bacterial infections commonly occur in late stages and result in fatal septicemia.
Source: Handbook of Diseases, 2003
Typically, CGL induces these signs and symptoms:
❑ anemia (fatigue, weakness, decreased exercise tolerance, pallor, dyspnea, tachycardia, and headache)
❑ thrombocytopenia, with resulting bleeding and clotting disorders (retinal hemorrhage, ecchymoses, hematuria, melena, bleeding gums, nosebleeds, and easy bruising)
❑ hepatosplenomegaly, with abdominal discomfort and pain; splenic infarction from leukemic cell infiltration.
Other signs and symptoms include sternal and rib tenderness from leukemic infiltrations of the periosteum; low-grade fever; weight loss; anorexia; renal calculi or gouty arthritis from increased uric acid excretion; occasionally, prolonged infection and ankle edema; and, rarely, priapism and vascular insufficiency.
Source: Handbook of Diseases, 2003
These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:
Full list of premium articles on symptoms and diagnosis
The symptom information on this page attempts to provide a list of some possible signs and symptoms of N syndrome. This signs and symptoms information for N syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of N syndrome signs or N syndrome symptoms. Furthermore, signs and symptoms of N syndrome may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed N syndrome symptoms.
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