Clinical Trials for Nephritis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Nephritis is grouped into the following categories:-

• View by trial name
• View by drugs used in Nephritis clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Nephritis:

• Immune System Related Kidney Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Aspreva Lupus Management Study (ALMS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Mycophenolate mofetil,Intravenous cyclophosphamide (active comparator, induction),Azathioprine (active comparator, maintenance)
• Study of LJP 394 in Lupus Patients With History of Renal Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - abetimus sodium (LJP 394)
• TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL ) - This study is currently recruiting patients (Current: 23 Nov 2006) - infliximab,azathioprine
• Study of Systemic Lupus Erythematosus - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide and Fludarabine to Treat Lupus Nephritis - This study has been completed (Current: 23 Nov 2006) - SQ Fludarabine
• Safety and Efficacy Study of LJP 394 (Abetimus Sodium) to Treat Lupus Kidney Disease - This study has been completed (Current: 23 Nov 2006) - Abetimus sodium (LJP 394)
• Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) - This study is no longer recruiting patients (Current: 23 Nov 2006) - CTLA4-IgG4m (RG2077)
• Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis. - This study is currently recruiting patients (Current: 23 Nov 2006) - Mycophenolate mofetil
• Study to Assess the Efficacy and Safety of FK506 Combined With MMF in Lupus Nephritis (III/IV/V) - This study is currently recruiting patients (Current: 23 Nov 2006) - FK506 and MMF(drug)
• To Compare the Efficacy and Safety of FK506 vs IVC in the Treatment of Class III-IV LN - This study has been completed (Current: 23 Nov 2006) - FK506 (Tacrolimus)
• Lupus Nephritis: Role of Environmental and Occupational Exposures - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006) - tacrolimus
• MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis - This study has been completed (Current: 23 Nov 2006) - Mycophenolate mofetil
• To Compare the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006) - tacrolimus and mycophenolate mofetil
• BG9588 (Anti-CD40L Antibody) to Treat Lupus Nephritis - This study has been completed (Current: 23 Nov 2006)
• A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With ISN/RPS Class III or IV Lupus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006) - Rituximab
• A Study of CellCept (Mycophenolate Mofetil) in Management of Patients With Lupus Nephritis. - This study is no longer recruiting patients (Current: 23 Nov 2006) - mycophenolate mofetil [CellCept]
• Induction Treatment of Proliferative Lupus Nephritis With Leflunomide Combined With Prednisone - This study has been completed (Current: 23 Nov 2006) - leflunomide combined with prednisone
• Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) - This study is currently recruiting patients (Current: 23 Nov 2006) - darbepoetin alfa
• Five-Year Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006) - cyclophosphamide-prednisone-azathioprine
• Sirolimus Therapy for Idiopathic and Lupus Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Sirolimus
• Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old - This study is currently recruiting patients (Current: 23 Nov 2006)
• Contrast-Enhanced US of Spleen, Liver and Kidney - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis - This study is no longer recruiting patients (Current: 23 Nov 2006) - doripenum
• Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis - This study is no longer recruiting patients (Current: 23 Nov 2006) - doripenum
• A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections - This study is no longer recruiting patients (Current: 23 Nov 2006) - Levofloxacin
• Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - ACE I, ATA II and Statins
• A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux - This study has been completed (Current: 23 Nov 2006) - sulfamethoxazole/trimethoprim or nitrofurantoin prophylaxis
• Cause of Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Genetic Markers for Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lamivudine for Chronic Hepatitis B - This study has been completed (Current: 23 Nov 2006) - Lamivudine
• Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) - This study is currently recruiting patients (Current: 23 Nov 2006) - Pirfenidone
• Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis - This study has been completed (Current: 23 Nov 2006)
• Alternate Day Prednisone or Daily Fish Oil Supplements in Patients With Immunoglobulin A Nephropathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - omega-3 fatty acids,prednisone
• Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis - This study has been completed (Current: 23 Nov 2006) - Dexamethasone
• Pilot Study of Enalapril and Renal Function in Patients With IgA Nephropathy - This study has been completed (Current: 23 Nov 2006) - enalapril
• Permeability Factor Protein in Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006) - Cyclophosphamide
• Sirolimus for Focal Segmental Glomerulosclerosis - This study has been completed (Current: 23 Nov 2006) - Sirolimus
• Retinoids for Minimal Change Disease and Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006) - Retinoids for Podocyte Disease
• Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney - This study has been completed (Current: 23 Nov 2006) - Spironolactone,Irbesartan
• Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT) - This study is currently recruiting patients (Current: 23 Nov 2006) - Mycophenolate Mofetil (MMF),Cyclosporin (CSA)
• Treatment of Patients With Idiopathic Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Cyclophosphamide and steroids
• Mycophenolate Mofetil in Membranous Nephropathy - This study has been completed (Current: 23 Nov 2006) - mycophenolate mofetil orally 1000 mg twice a day (BID),prednisone 0,5 mg/kg orally on alternate days,intravenous (i.v.) methylprednisolone 1000 mg, total 9
• Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis - This study has been completed (Current: 23 Nov 2006) - pentoxifylline
• Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil Versus Intravenous Cyclophosphamide Pulses in the Treatment of Crescentic IgA Nephropathy - This study has been completed (Current: 23 Nov 2006) - Mycophenolate mofetil
• Tacrolimus Treatment of Patients With Idiopathic Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Tacrolimus
• Tacrolimus Treatment of Patients With Idiopathic Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006) - Tacrolimus
• Mycophenolate Mofetil (MMF) in Patients With IgA Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Mycophenolate Mofetil
• Calcitriol in the Treatment of IgA Nephropathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Calcitriol
• Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis - This study has been completed (Current: 23 Nov 2006) - Ng-monomethyl-L-arginine (drug)
• Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft - This study has been completed (Current: 23 Nov 2006)
• Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Rapidly Progressive Glomerulonephritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - pentoxifylline
• Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome - This study has been completed (Current: 23 Nov 2006) - tacrolimus combined with prednisone
• Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy - This study has been completed (Current: 23 Nov 2006) - ENALAPRIL VALSARTAN METHYLPREDNISONE
• ACEi/ARB Alone Versus ACEi/ARB Plus Steroids in the Treatment of Primary IgA Nephropathy, a RCT - This study is no longer recruiting patients (Current: 23 Nov 2006) - prednisone + Inhibace/Cozaar,Inhibace/Cozaar
• Pilot Trial of Treatment of Poor-Prognosis Iga Nephropathy With Low Exposure to Sirolimus. - This study is currently recruiting patients (Current: 23 Nov 2006) - sirolimus
• Study of LJP 394 (Abetimus Sodium) in Lupus Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - abetimus sodium (LJP 394)
• Monoclonal Antibody Treatment for Systemic Lupus Erythematosus - This study is currently recruiting patients (Current: 23 Nov 2006) - MRA

Drugs used in Clinical Trials for Nephritis

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Nephritis:

• ACE I, ATA II and Statins - Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Abetimus Sodium (Ljp 394) - Study of LJP 394 (Abetimus Sodium) in Lupus Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Abetimus Sodium (Ljp 394) - Study of LJP 394 in Lupus Patients With History of Renal Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Abetimus sodium (LJP 394) - Safety and Efficacy Study of LJP 394 (Abetimus Sodium) to Treat Lupus Kidney Disease - This study has been completed (Current: 23 Nov 2006)
• Azathioprine (active comparator, maintenance) - Aspreva Lupus Management Study (ALMS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Azathioprine - TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL ) - This study is currently recruiting patients (Current: 23 Nov 2006)
• CTLA4-IgG4m (RG2077) - Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Calcitriol - Calcitriol in the Treatment of IgA Nephropathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Cyclophosphamide and steroids - Treatment of Patients With Idiopathic Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide-Prednisone-Azathioprine - Five-Year Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Permeability Factor Protein in Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclosporin (CSA) - Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Darbepoetin Alfa - Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis - This study has been completed (Current: 23 Nov 2006)
• Doripenum - Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Doripenum - Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• ENALAPRIL VALSARTAN METHYLPREDNISONE - Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy - This study has been completed (Current: 23 Nov 2006)
• Enalapril - Pilot Study of Enalapril and Renal Function in Patients With IgA Nephropathy - This study has been completed (Current: 23 Nov 2006)
• FK506 (Tacrolimus) - To Compare the Efficacy and Safety of FK506 vs IVC in the Treatment of Class III-IV LN - This study has been completed (Current: 23 Nov 2006)
• FK506 and MMF(drug) - Study to Assess the Efficacy and Safety of FK506 Combined With MMF in Lupus Nephritis (III/IV/V) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Infliximab - TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL ) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Inhibace/Cozaar - ACEi/ARB Alone Versus ACEi/ARB Plus Steroids in the Treatment of Primary IgA Nephropathy, a RCT - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravenous (I.V.) Methylprednisolone 1000 Mg, Total 9 - Mycophenolate Mofetil in Membranous Nephropathy - This study has been completed (Current: 23 Nov 2006)
• Intravenous cyclophosphamide (active comparator, induction) - Aspreva Lupus Management Study (ALMS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Irbesartan - Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney - This study has been completed (Current: 23 Nov 2006)
• Lamivudine - Lamivudine for Chronic Hepatitis B - This study has been completed (Current: 23 Nov 2006)
• Leflunomide Combined With Prednisone - Induction Treatment of Proliferative Lupus Nephritis With Leflunomide Combined With Prednisone - This study has been completed (Current: 23 Nov 2006)
• Levofloxacin - A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Levofloxacin - A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections - This study is no longer recruiting patients (Current: 23 Nov 2006)
• MRA - Monoclonal Antibody Treatment for Systemic Lupus Erythematosus - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil (MMF) - Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil Orally 1000 Mg Twice A Day (Bid) - Mycophenolate Mofetil in Membranous Nephropathy - This study has been completed (Current: 23 Nov 2006)
• Mycophenolate Mofetil [Cellcept] - A Study of CellCept (Mycophenolate Mofetil) in Management of Patients With Lupus Nephritis. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil - Mycophenolate Mofetil (MMF) in Patients With IgA Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate mofetil - Aspreva Lupus Management Study (ALMS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate mofetil - MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis - This study has been completed (Current: 23 Nov 2006)
• Mycophenolate mofetil - Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate mofetil - Mycophenolate Mofetil Versus Intravenous Cyclophosphamide Pulses in the Treatment of Crescentic IgA Nephropathy - This study has been completed (Current: 23 Nov 2006)
• Ng-monomethyl-L-arginine (drug) - Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis - This study has been completed (Current: 23 Nov 2006)
• Omega-3 Fatty Acids - Alternate Day Prednisone or Daily Fish Oil Supplements in Patients With Immunoglobulin A Nephropathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pentoxifylline - Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Rapidly Progressive Glomerulonephritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Pentoxifylline - Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis - This study has been completed (Current: 23 Nov 2006)
• Pirfenidone - Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisone + Inhibace/Cozaar - ACEi/ARB Alone Versus ACEi/ARB Plus Steroids in the Treatment of Primary IgA Nephropathy, a RCT - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Prednisone 0,5 Mg/Kg Orally On Alternate Days - Mycophenolate Mofetil in Membranous Nephropathy - This study has been completed (Current: 23 Nov 2006)
• Prednisone - Alternate Day Prednisone or Daily Fish Oil Supplements in Patients With Immunoglobulin A Nephropathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Retinoids for Podocyte Disease - Retinoids for Minimal Change Disease and Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rituximab - A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With ISN/RPS Class III or IV Lupus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006)
• SQ Fludarabine - Cyclophosphamide and Fludarabine to Treat Lupus Nephritis - This study has been completed (Current: 23 Nov 2006)
• Sirolimus - Pilot Trial of Treatment of Poor-Prognosis Iga Nephropathy With Low Exposure to Sirolimus. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sirolimus - Sirolimus Therapy for Idiopathic and Lupus Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sirolimus - Sirolimus for Focal Segmental Glomerulosclerosis - This study has been completed (Current: 23 Nov 2006)
• Spironolactone - Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney - This study has been completed (Current: 23 Nov 2006)
• Sulfamethoxazole/Trimethoprim Or Nitrofurantoin Prophylaxis - A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux - This study has been completed (Current: 23 Nov 2006)
• Tacrolimus And Mycophenolate Mofetil - To Compare the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tacrolimus Combined With Prednisone - Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome - This study has been completed (Current: 23 Nov 2006)
• Tacrolimus - Tacrolimus Treatment of Patients With Idiopathic Focal Segmental Glomerulosclerosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tacrolimus - Tacrolimus Treatment of Patients With Idiopathic Membranous Nephropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tacrolimus - Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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