Neurofibromatosis-1: Genetic disorder often leading to tumors on nerves. More detailed information about the symptoms, causes, and treatments of Neurofibromatosis-1 is available below.
See full list of 22 symptoms of Neurofibromatosis-1
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Read more about Misdiagnosis and Neurofibromatosis-1
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Prognosis for Neurofibromatosis-1: NF1 is usually mild, though it can sometimes be severe.
More about prognosis of Neurofibromatosis-1
Visit our research pages for current research about Neurofibromatosis-1 treatments.
The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.
Some of the clinical trials listed on ClinicalTrials.gov for Neurofibromatosis-1 include:
See full list of 12 Clinical Trials for Neurofibromatosis-1
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Type 1 (peripheral) neurofibromatosis (von Recklinghausen's disease), is the most common type of neurofibromatosis. It is characterized clinically by cutaneous and subcutaneous tumors with patches of hyperpigmentation. The hyperpigmented skin areas, are present from birth and found anywhere on the body surface. They can vary markedly in size and color. The dark brown areas are called cafe-au-lait spots. The multiple cutaneous and subcutaneous tumors are nerve sheath neoplasms, called neurofibromas. They can develop anywhere along the peripheral nerve fibers. Neurofibromas can become quite large, causing a major disfigurement, eroding bone, and compressing various peripheral nerve structures. Type 1 neurofibromatosis has dominant inheritance, with a gene locus on the proximal long arm of chromosome 17. -- 2003 - (Source - Diseases Database)
Neurofibromatosis-1 is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Neurofibromatosis-1, or a subtype of Neurofibromatosis-1,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Neurofibromatosis-1 as a "rare disease".
Source - Orphanet
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