The list of signs and symptoms mentioned in various sources for Neurofibromatosis-2 includes the 35 symptoms listed below:
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Signs and symptoms of NF-1 vary greatly from one family to another and within members of the same family. A patient with seemingly mild symptoms initially may develop more severe problems later.
An infant with this form may present with only café-au-lait spots or may also have congenital glaucoma, plexiform neurofibromas, or pseudoarthrosis. About 90% of patients have Lisch nodules on the iris; as many as 15% develop optic pathway gliomas, which may cause a significant loss of vision.
Cutaneous and other neurofibromas may begin to develop or become more prominent at puberty; pregnancy may exacerbate tumor growth. Some tumors become malignant; approximately 8% of patients develop neurofibrosarcoma (cancer of the nerve sheath). Other less-specific features may include other types of tumors (such as meningiomas), short stature, seizures, speech and learning disabilities, mental retardation (occasionally), and abnormalities of the cerebral, GI, and renal arteries.
The first sign of NF-2 is usually a central nervous system tumor, such as a spinal or intracranial meningioma, an acoustic neuroma, and occasionally a schwannoma or spinal astrocytoma. Cutaneous neurofibromas may be less conspicuous in this form, and café-au-lait spots may be minimal or even absent. Learning disabilities and other less-specific features characteristic of NF-1 aren't typically seen in NF-2.
Source: Professional Guide to Diseases (Eighth Edition), 2005
NF2 is characterized by bilateral (occurring on both sides of the body) tumors on the eighth cranial nerve. The tumors cause pressure damage to neighboring nerves. To determine whether an individual has NF2, a physician looks for bilateral eighth nerve tumors and similar signs and symptoms in a parent, sibling, or child. Affected individuals may notice hearing loss as early as the teen years. Other early symptoms may include tinnitus (ringing noise in the ear) and poor balance. Headache, facial pain, or facial numbness, caused by pressure from the tumors, may also occur. (Source: excerpt from NINDS Neurofibromatosis Information Page: NINDS)
When considering symptoms of Neurofibromatosis-2, it is also important to consider Neurofibromatosis-2 as a possible cause of other medical conditions. The Disease Database lists the following medical conditions that Neurofibromatosis-2 may cause:
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The symptom information on this page attempts to provide a list of some possible signs and symptoms of Neurofibromatosis-2. This signs and symptoms information for Neurofibromatosis-2 has been gathered from various sources, may not be fully accurate, and may not be the full list of Neurofibromatosis-2 signs or Neurofibromatosis-2 symptoms. Furthermore, signs and symptoms of Neurofibromatosis-2 may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Neurofibromatosis-2 symptoms.
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