What is Neuroleptic Malignant Syndrome?

What is Neuroleptic Malignant Syndrome?

• Neuroleptic Malignant Syndrome: A severe, potentially fatal reaction to antipsychotic drugs.
• Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
  Source - Diseases Database

Neuroleptic Malignant Syndrome: Introduction

Types of Neuroleptic Malignant Syndrome:

Broader types of Neuroleptic Malignant Syndrome:

• Brain conditions
• more types...»

How serious is Neuroleptic Malignant Syndrome?

Complications of Neuroleptic Malignant Syndrome: see complications of Neuroleptic Malignant Syndrome
Prognosis of Neuroleptic Malignant Syndrome: Early identification of and treatment for individuals with neuroleptic malignant syndrome improves outcome. (Source: excerpt from NINDS Neuroleptic Malignant Syndrome Information Page: NINDS)

What causes Neuroleptic Malignant Syndrome?

Causes of Neuroleptic Malignant Syndrome: see causes of Neuroleptic Malignant Syndrome

What are the symptoms of Neuroleptic Malignant Syndrome?

Symptoms of Neuroleptic Malignant Syndrome: see symptoms of Neuroleptic Malignant Syndrome

Complications of Neuroleptic Malignant Syndrome: see complications of Neuroleptic Malignant Syndrome

Neuroleptic Malignant Syndrome: Testing

Diagnostic testing: see tests for Neuroleptic Malignant Syndrome.

Misdiagnosis: see misdiagnosis and Neuroleptic Malignant Syndrome.

How is it treated?

Treatments for Neuroleptic Malignant Syndrome: see treatments for Neuroleptic Malignant Syndrome
Research for Neuroleptic Malignant Syndrome: see research for Neuroleptic Malignant Syndrome

Organs Affected by Neuroleptic Malignant Syndrome:

Organs and body systems related to Neuroleptic Malignant Syndrome include:

• Brain

Name and Aliases of Neuroleptic Malignant Syndrome

Main name of condition: Neuroleptic Malignant Syndrome

NMS, supersensitivity syndrome

Research the causes of these diseases that are similar to, or related to, Neuroleptic Malignant Syndrome:

• Creatinine kinase
• Levodopa
• Parkinson's disease
• Dopaminergic drugs
• Delirium
• Fever
• Metabolic acidosis
• Hypertensive crisis
• Diaphoresis
• Muscle rigidity

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