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The fluorescent treponemal antibody-absorption test identifies antigens of T. pallidum in tissue, ocular fluid, cerebrospinal fluid (CSF), tracheobronchial secretions, and exudates from lesions. This is the most sensitive test available for detecting syphilis in all stages. Once reactive, it remains so permanently.
Other appropriate procedures include the following:
❑ Venereal Disease Research Laboratory (VDRL) slide test and rapid plasma reagin test (RPR) detect nonspecific antibodies. Both tests, if positive, become reactive within 1 to 2 weeks after the primary lesion appears or 4 to 5 weeks after the infection begins.
❑ CSF examination identifies neurosyphilis when the total protein level is above 40 mg/dl, the VDRL slide test is reactive, and the cell count exceeds five mononuclear cells/µl.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Identifying T. pallidum from a lesion on a dark-field examination provides immediate diagnosis of syphilis. This method is most effective when moist lesions are present, as in primary, secondary, and prenatal syphilis.
The fluorescent treponemal antibody-absorption test identifies antigens of T. pallidum tissue, ocular fluid, cerebrospinal fluid (CSF), tracheobronchial secretions, and exudates from lesions. This is the most sensitive test available for detecting syphilis in all stages. After it becomes reactive, it remains so permanently.
Other appropriate procedures include the following:
❑ Venereal Disease Research Laboratory (VDRL) slide test and rapid plasma reagin test detect nonspecific antibodies. Both tests, if positive, become reactive within 1 to 2 weeks after the primary lesion appears or 4 to 5 weeks after the infection begins.
❑ CSF examination identifies neurosyphilis when the total protein level is above 40 mg/100 ml, VDRL slide test is reactive, and CSF cell count exceeds five mononuclear cells/µl.
Source: Handbook of Diseases, 2003
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