Conditions listing Osteogenesis imperfecta as a symptom may also be potential underlying causes of Osteogenesis imperfecta. Our database lists the following as having Osteogenesis imperfecta as a symptom of that condition:
Causes: Osteogenesis imperfecta:
Also
known as "brittle bone disease," this disorder arises from
mutations in the two genes that make type I collagen, a protein
important to bones and skin. These mutations cause the body to
make either too little or poor-quality type I
collagen.
(Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS)
The following medical news items are relevant to causes of Osteogenesis imperfecta:
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Osteogenesis imperfecta may be found in:
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Osteogenesis imperfecta.
Osteogenesis imperfecta can result from autosomal dominant inheritance of a defect in the amount of Type I collagen, an important part of the bone matrix. Clinical signs may result from defective osteoblastic activity and a defect of mesenchymal collagen (embryonic connective tissue) and its derivatives (sclerae, bones, and ligaments). The reticulum fails to differentiate into mature collagen or causes abnormal collagen development, leading to immature and coarse bone formation. Cortical bone thinning also occurs.
Type I, the most common form of osteogenesis imperfecta, occurs in about 1 in 30,000 live births. Both types I and IV are thought to be inherited as an autosomal dominant trait. Types II and III are believed to be inherited as an autosomal recessive trait.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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