Osteogenesis imperfecta

Osteogenesis imperfecta: Introduction

Osteogenesis imperfecta: People with osteogenesis imperfecta (OI) have bones that fracture easily, low muscle mass, and joint and ligament laxity. (Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS) ... more about Osteogenesis imperfecta.

Osteogenesis imperfecta: Weak bones ("brittle bone disease") and loose joints. More detailed information about the symptoms, causes, and treatments of Osteogenesis imperfecta is available below.

Symptoms of Osteogenesis imperfecta

• Brittle bones
• Fractures
• Fracturing easily
• Low muscle mass
• Newborn born with multiple fractures - in severe cases
• more symptoms...»

See full list of 15 symptoms of Osteogenesis imperfecta

Home Diagnostic Testing

Home medical testing related to Osteogenesis imperfecta:

• Osteoporosis & Bone Health: Home Testing:
  • Home Osteoporosis Tests
  • Home Bone Loss Tests
• more tests...»

Osteogenesis imperfecta: Complications

Review possible medical complications related to Osteogenesis imperfecta:

• Fractures
• Scoliosis
• Respiratory problems
• Otosclerosis
• Hearing loss
• more complications...»

Medical Textbooks Online about Osteogenesis imperfecta

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Wrongly Diagnosed with Osteogenesis imperfecta?

• Misdiagnosis of Osteogenesis imperfecta
• Failure to diagnose Osteogenesis imperfecta
• Hidden causes of Osteogenesis imperfecta (possibly wrongly diagnosed)
• Undiagnosed: Osteogenesis imperfecta

Misdiagnosis and Osteogenesis imperfecta

Look for Van der Hoeve's syndrome in cases of osteogenesis imperfecta: Van Der Hoeve's syndrome is characterised by a triad of osteogenesis imperfecta, otosclerosis and blue sclera. It occurs due to a defect in collagen synthesis which affects the bones, sclera and the ear ossicles. Defect in collagen synthesis causes multiple fractures in osteogenesis imperfecta, fixation of the footplate of stapes hence causing limited mobility of the stapes causing deafness in otosclerosis and the blue sclera appearance is due to the excessively thin sclera reflecting the uveal tissue. Osteogenesis imperfecta must be differentiated from other conditions such as Battered baby syndrome, juvenile osteoporosis and steroid induced osteoporosis....read more »

Read more about Misdiagnosis and Osteogenesis imperfecta

Osteogenesis imperfecta: Research Doctors & Specialists

Research related physicians and medical specialists:

• Bone, Joint and Orthopedic Specialists:
  • Orthopedic Surgery
  • Neuromusculoskeletal Medicine
  • Rheumatology (Arthritis / Joint Pain)
• more specialists...»

Other doctor, physician and specialist research services:

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Causes of Osteogenesis imperfecta

Read more about causes of Osteogenesis imperfecta.

More information about causes of Osteogenesis imperfecta:

• Osteogenesis imperfecta as a symptom
• Medical news summaries relating to Causes of Osteogenesis imperfecta

Treatments for Osteogenesis imperfecta

• Supportive treatment, orthopedic supports
• Various treatments for fractures
• Genetic counselling
• more treatments...»

Read more about treatments for Osteogenesis imperfecta

Latest Treatments for Osteogenesis imperfecta

• Physiotherapy
• Orthotic support
• Biphosphonates
• Pamidronate
• Growth hormone
• more treatments...»

See full list of 9 latest treatments for Osteogenesis imperfecta

News Archives for Osteogenesis imperfecta

Medical news articles related to Osteogenesis imperfecta include:

• Do Antidepressants Make Bones Brittle?
• more health news...»

Source: HealthDay News

Evidence Based Medicine Research for Osteogenesis imperfecta

Medical research articles related to Osteogenesis imperfecta include:

• Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK
• A systematic review of the effectiveness of strategies for reducing fracture risk in children with juvenile idiopathic arthritis with additional data on long-term risk of fracture and cost of disease management
• I would like information about the genetics of Osteogenesis Imperfecta. I have a female baby patient whose paternal cousin is affected.
• Bisphosphonate therapy for osteogenesis imperfecta
• Risk factor assessment for osteoporosis and/or increased fracture risk in men.
• more research...»

Click here to find more evidence-based articles on the TRIP Database

Videos for Osteogenesis imperfecta

Patient Surveys for Osteogenesis imperfecta

• Patient Profile Survey
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• Survey about the symptoms of your Osteogenesis imperfecta
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Prognosis for Osteogenesis imperfecta

Prognosis for Osteogenesis imperfecta: There are four major types of OI ranging in severity from mild to lethal. (Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS)

More about prognosis of Osteogenesis imperfecta

Reseach about Osteogenesis imperfecta

Visit our research pages for current research about Osteogenesis imperfecta treatments.

Clinical Trials for Osteogenesis imperfecta

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Osteogenesis imperfecta include:

• Bisphosphonate Treatment of Osteogenesis Imperfecta - This study is currently recruiting patients (Current: 23 Nov 2006) - Zoledronic Acid
• Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta - This study is currently recruiting patients (Current: 23 Nov 2006) - Teriparatide (FORTEO)
• Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta - This study is currently recruiting patients (Current: 23 Nov 2006) - Zoledronic Acid
• Growth Hormone Therapy in Osteogenesis Imperfecta - This study is currently recruiting patients (Current: 23 Nov 2006) - Humatrope,GRH,Nutropin
• Evaluation and Intervention for the Effects of Osteogenesis Imperfecta - This study is currently recruiting patients (Current: 23 Nov 2006)
• more trials...»

See full list of 10 Clinical Trials for Osteogenesis imperfecta

Statistics for Osteogenesis imperfecta

• Medical statistics for Osteogenesis imperfecta
• Prevalence and incidence statistics for Osteogenesis imperfecta
• Death and Mortality statistics for Osteogenesis imperfecta
• Society statistics for Osteogenesis imperfecta

Osteogenesis imperfecta: Broader Related Topics

• Bone conditions
• Connective tissue disorders
• Heritable Disorders of Connective Tissue
• Genetic Disease
• more types...»

Types of Osteogenesis imperfecta

Types of Osteogenesis imperfecta

• Osteogenesis imperfecta congenita - affecting newborns
• Osteogenesis imperfecta tarda
• more types...»

Read more about Types of Osteogenesis imperfecta

Stories from Users Related to Osteogenesis imperfecta

• Diagnosing Brittle Bones!help!!

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User Interactive Forums

Read about other experiences, ask a question about Osteogenesis imperfecta, or answer someone else's question, on our message boards:

• I can not get a diagnosis. Please help.
• Tell us your medical story.
• Share your misdiagnosis story.
• What is the best treatment for this?
• See all the forums.

Article Excerpts about Osteogenesis imperfecta

People with osteogenesis imperfecta (OI) have bones that fracture easily, low muscle mass, and joint and ligament laxity. (Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS)

Definitions of Osteogenesis imperfecta:

Autosomal dominant COLLAGEN DISEASES resulting from defective biosynthesis of COLLAGEN TYPE I and characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. There are four major types, I-IV. - (Source - Diseases Database)

Autosomal dominant disorder of connective tissue characterized by brittle bones that fracture easily - (Source - WordNet 2.1)

Osteogenesis imperfecta is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Osteogenesis imperfecta, or a subtype of Osteogenesis imperfecta, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Osteogenesis imperfecta as a "rare disease".
Source - Orphanet