6-7 per 100,000 people are affected by osteogenesis imperfecta worldwide, Genetics Home Reference website ... see also overview of Osteogenesis imperfecta.
approx 1 in 16,666 or 0.01% or 16,320 people in USA [Source statistic for calcuation: "6-7 per 100,000 people are affected by osteogenesis imperfecta worldwide, Genetics Home Reference website" -- see also general information about data sources]
Osteogenesis imperfecta is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Osteogenesis imperfecta, or a subtype of Osteogenesis imperfecta, affects less than 200,000 people in the US population.
Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Osteogenesis imperfecta as a "rare disease". More information about Osteogenesis imperfecta is available from Orphanet
about 1 in 10,0001. ... see also overview of Osteogenesis imperfecta.
approx 1 in 10,000 or 0.01% or 27,200 people in USA [Source statistic for calcuation: "about 1 in 10,0001." -- see also general information about data sources]
27,199 per year, 2,266 per month, 523 per week, 74 per day, 3 per hour, 0 per minute, 0 per second. [Source statistic for calculation: "about 1 in 10,0001." -- see also general information about data sources]
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Osteogenesis imperfecta.
Osteogenesis imperfecta can result from autosomal dominant inheritance of a defect in the amount of Type I collagen, an important part of the bone matrix. Clinical signs may result from defective osteoblastic activity and a defect of mesenchymal collagen (embryonic connective tissue) and its derivatives (sclerae, bones, and ligaments). The reticulum fails to differentiate into mature collagen or causes abnormal collagen development, leading to immature and coarse bone formation. Cortical bone thinning also occurs.
Type I, the most common form of osteogenesis imperfecta, occurs in about 1 in 30,000 live births. Both types I and IV are thought to be inherited as an autosomal dominant trait. Types II and III are believed to be inherited as an autosomal recessive trait.
Source: Professional Guide to Diseases (Eighth Edition), 2005
~1 in 20,000
Source: The 5-Minute Pediatric Consult, 2008
The term 'prevalence' of Osteogenesis imperfecta usually refers to the estimated population
of people who are managing Osteogenesis imperfecta at any given time.
The term 'incidence' of Osteogenesis imperfecta refers to the annual diagnosis rate,
or the number of new cases of Osteogenesis imperfecta diagnosed each year.
Hence, these two statistics types can differ:
a short-lived disease like flu can have high annual incidence but low prevalence,
but a life-long disease like diabetes has a low annual incidence but high prevalence.
For more information see about prevalence and incidence statistics.
Footnotes:
1. Pathophysiology of Disease, Stephen J. McPhee, Vishwanash R. Lingappa, Willim F. Ganong, Jack D. Lang, Prentice Hall, 1995
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