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Diseases » Osteomalacia » Glossary

Glossary for Osteomalacia

Acid phosphatase deficiency: A group of inherited metabolic bone disorders varying in degree of severity and characterized a deficiency of alkaline phosphate which affects bone mineralization.
Acid-Base Imbalance: A disruption to the normal acid-base equilibrium in the body. There are four main groups of disorder involving an acid-base imbalance: respiratory acidosis or alkalosis and metabolic acidosis or alkalosis. Obviously the severity of symptoms is determined by the degree of imbalance.
Adult hypophosphatasia: An rare inherited bone disorder due to an inborn error of metabolism characterized by a deficiency of alkaline phosphate. The condition involves the early loss of primary teeth and childhood rickets followed by a reasonable health until mid-adulthood when dental and skeletal abnormalities again become prevalent.
Aluminium toxicity: High body levels of aluminium resulting in symptoms. Usually occurs in patients with renal impairment.
Bone pain: Bone pain or tenderness is aching or other discomfort in one or more bones.
Celiac Disease: Digestive intolerance to gluten in the diet.
Cholestasis: A condition where the bile flow is impaired or completely halted.
Cystinosis: A rare biochemical disorder involving the accumulation of a chemical called cystine in various parts of the body which can cause harmful effects.
Fanconi renotubular syndrome: A condition where the kidneys are unable to reabsorb glucose and amino acids and hence they are excreted in the urine. The condition may be inherited or occur as a result of heavy metal toxicity, malignancy and myeloma.
Fanconi syndrome: Fanconi syndrome that occurs secondary to the accumulation of crystals of light-chain immunoglobulin molecules in the kidney tubules which affects their functioning.
Fibromyalgia: A difficult to diagnose condition affecting the muscles and/or joints
Fractures: Fracture of a bone; also "broken bone".
Genu varum: The presence of bowed legs - knees are apart and ankles are together while standing. Causes of the anomaly include certain intrauterine positions, rickets and various bone disorders.
Hereditary primary Fanconi disease: A rare inherited disorder characterized by defective reabsorption of various substances such as phosphate, potassium, amino acids and glucose which manifests as a wide range of abnormalities and problems.
Hypocalcaemia: Decreased concentration of calcium in the blood.
Hypocalcemia: Low levels of calcium in the blood
Hypophosphatasia: A rare genetic disorder characterized by short limbs, dwarfism and general lack of bone calcification.
Hypophosphatemia: Low blood phosphate levels. Causes include malnourishment, chronic alcoholism excessive carbohydrate consumption, malabsorption, phosphaturia, liver failure, respiratory alkalosis and certain genetic disorders.
Hypophosphatemia, Familial: An inherited disorder involving low blood phosphate levels due to problems with the transport of phosphate and problems with vitamin D metabolism. Vitamin D and phosphates are not properly absorbed from the kidneys which can lead to bone problems if not treated.
Leg pain: Pain affecting the leg
Malabsorption: Failure to digest nutrients properly
Malabsorption syndrome: is an alteration in the ability of the intestine to absorb nutrients adequately into the bloodstream
Metastatic cancer: Any cancer that has spread to other parts of the body.
Multiple Myeloma: A rare malignant cancer that occurs in the bone marrow. More common in skull, spine, rib cage, pelvis and legs.
Muscle weakness: A condition which is characterized by an inability of the muscles to function at their full strenght
Myopathy: General name for any disease of the muscles.
Myositis: One of the underlying causes for muscle weakness/myopathy.
Osteoporosis: Bone thinning and weakening from bone calcium depletion.
Pathological fracture: The occurrence of a fracture a bone of the body caused by a disease state
Primary biliary cirrhosis: Primary biliary cirrhosis is a chronic and progressive cholestatic disease of the liver.
Proximal Renal Tubular Acidosis: This is a condition that is characterised by a metabolic acidosis state caused by impairment of a persons renal function
Proximal muscle weakness: Weakness of the proximal muscles
Renal Tubular Acidosis: A rare disorder where the kidneys secrete too much hydrogen and don't reabsorb enough bicarbonate which can result in symptoms such as excessive blood acidity and loss of potassium.
Renal osteodystrophy: Lack of bone mineralization due to kidney disease.
Renal tubular acidosis progressive nerve deafness: A kidney disorder where progressive nerve deafness is associated with the kidney's is inability to effectively remove acid from the blood and excrete it into the urine. The defect occurs in the distant portion of the kidney tubules whose job is to remove acid from the blood and excrete it through the urine.
Renal tubular acidosis, distal: A kidney disorder where the kidney is unable to effective remove acid from the blood and excrete it into the urine. The defect occurs in the distant portion of the kidney tubules whose job is to remove acid from the blood and excrete it through the urine.
Renal tubular acidosis, distal - type I: A kidney disorder where the kidney is unable to effective remove acid from the blood and excrete it into the urine. The defect occurs in the distant portion of the kidney tubules whose job is to remove acid from the blood and excrete it through the urine. Type I also involves potassium level abnormalities.
Renal tubular acidosis, distal - type III: A kidney disorder where the kidney is unable to effective remove acid from the blood and excrete it into the urine. The defect occurs in the distant portion of the kidney tubules whose job is to remove acid from the blood and excrete it through the urine. Type III involves the potassium level abnormalities of type I as well as bicarbonate level abnormalities resulting from excessive bicarbonate removal from the blood at the proximal part of the kidney tubules.
Renal tubular acidosis, distal, autosomal dominant: A rare kidney disorder characterized mainly by increased urine alkalinity and high blood acidity due to abnormal kidney functioning.
Rickets: A rare condition where a lack of Vitamin D results in bone disease as it is essential for the process of bone calcification.
Toni-Fanconi syndrome type 1:
Vitamin D deficiency: Deficiency of vitamin D
Weak bones: Weakening of the bones
Wilson's Disease: Wilson disease, or hepatolenticular degeneration, is a neurodegenerative disease of copper metabolism.