As with all medical conditions, there may be many causal factors. Further relevant information on causes of Paget's disease of bone may be found in:
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The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand, where it’s seen in up to 5% of the elderly population. Although its exact cause is unknown, one theory holds that early viral infection causes a dormant skeletal infection that erupts many years later as Paget’s disease. Genetic factors are also suspected.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Paget’s disease occurs worldwide but is more common in Europe, Australia, and New Zealand, where it’s seen in up to 5% of the elderly population.
Although its exact cause is unknown, one theory holds that early viral infection (possibly with mumps virus) causes a dormant skeletal infection that erupts many years later as Paget’s disease. In 5% of the patients, the involved bone will undergo malignant changes.
Source: Handbook of Diseases, 2003
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