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Glossary for Paget's disease of bone

  • Angioid streaks: Streaks that radiate out from the optic nerve head under the retina. The streaks may be red, brown or grey. The streaks resemble blood vessels and hence the term angioid. The streaks represent tiny breaks in the elastic membrane of the retina (Bruch's membrane). The anomaly is often associated with conditions such as Paget's disease, sickle cell anemia, Ehlers-Danlos syndrome and pseudoxanthoma elasticum.
  • Arthritis: General name for any type of joint inflammation, but often means age-related osteoarthritis.
  • Bone cancer: Malignancy that occurs in the bone
  • Bone changes: Changes to the bones as a symptom
  • Bone pain: Bone pain or tenderness is aching or other discomfort in one or more bones.
  • Brain compression: Internal compression of the brain
  • Conductive hearing loss: Hearing loss due to a defect in the external auditory canal or middle ear.
  • Congestive Heart Failure: Inadequate pumping and decline of heart function common in the elderly.
  • Fibrous Dysplasia: A rare condition where fibrous tissues develops instead of normal bone tissue. One or more bones may be affected and bones in the legs, head and chest are the usual ones affected.
  • Fractures: Fracture of a bone; also "broken bone".
  • Genu varum: The presence of bowed legs - knees are apart and ankles are together while standing. Causes of the anomaly include certain intrauterine positions, rickets and various bone disorders.
  • Heart disease: Any of various heart conditions.
  • Hip Arthritis: Inflammation of the hip joint. The inflammation can be the result of such things as degenerative joint disease, gout, infection, trauma and autoimmune conditions.
  • Hyperparathyroidism: Increased secretion of parathyroid hormone from the parathyroid glands.
  • Hypertension: High blood pressure
  • Kyphosis: Outward curvature of the spine at the back causing hunching or Dowager's hump
  • Metastatic cancer: Any cancer that has spread to other parts of the body.
  • Multiple Myeloma: A rare malignant cancer that occurs in the bone marrow. More common in skull, spine, rib cage, pelvis and legs.
  • No symptoms: The absence of noticable symptoms.
  • Osteitis: Inflammation of the bone.
  • Osteoporosis: Bone thinning and weakening from bone calcium depletion.
  • Osteosarcoma: Osteosarcoma is the most common type of malignant bone cancer, accounting for 35% of primary bone malignancies. There is a preference for the metaphyseal region of tubular long bones. 50% of cases occur around the knee.
  • Paget's Disease: Breast carcinoma involving nipple and areola.
  • Pathological fracture: The occurrence of a fracture a bone of the body caused by a disease state
  • Pelvis conditions: Any condition that affects the pelvis
  • Peripheral neuropathy: Peripheral neuropathy is the term for damage to nerves of the peripheral nervous system, which may be caused either by diseases of the nerve or from the side-effects of systemic illness.
  • Respiratory syncytial virus: Viral respiratory infection serious in young infants.
  • Secondary Bone Cancer: Tumour development in bone as a result of spread from a primary malignant tumour from another body site (usually lung bronchus, breast and prostate)
  • Sensorineural hearing loss: Hearing loss due to abnormal functioning or damage to the hearing nerve or the cochlea (inner ear) or the part of the brain that processes sound. The hearing problem may be present at birth or may be acquired through such things as aging, excessive noise or diseases such as meningitis.
  • Spinal conditions: Any condition that affects the spine
  • Swollen bone: Enlarged, swollen, or misshapen bones
  • Vague symptoms: Vague, unclear, mild or non-specific symptoms


 » Next page: Clinical Trials for Paget's disease of bone

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