The list of signs and symptoms mentioned in various sources for Paget's disease of bone includes the 42 symptoms listed below:
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The list of other diseases or medical conditions that may be on the differential diagnosis list of alternative diagnoses for Paget's disease of bone includes:
See the full list of 12 alternative diagnoses for Paget's disease of bone
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Clinical effects of Paget’s disease vary. Early stages may be asymptomatic, but when pain does develop, it’s usually severe and persistent and may coexist with impaired movement resulting from impingement of abnormal bone on the spinal cord or sensory nerve root. Such pain intensifies with weight bearing.
The patient with skull involvement shows characteristic cranial enlargement over frontal and occipital areas (hat size may increase) and may complain of headaches. Other deformities include kyphosis (spinal curvature due to compression fractures of pagetic vertebrae), accompanied by a barrel-shaped chest and asymmetrical bowing of the tibia and femur, which commonly reduces height. Pagetic sites are warm and tender and are susceptible to pathologic fractures after minor trauma. Pagetic fractures heal slowly and usually incompletely.
Bony impingement on the cranial nerves may cause blindness and hearing loss with tinnitus and vertigo. Other complications include hypertension, renal calculi, hypercalcemia, gout, heart failure, and a waddling gait (from softening of pelvic bones).
Source: Professional Guide to Diseases (Eighth Edition), 2005
Clinical features of Paget’s disease vary.
A patient in the early stages of the disease may be asymptomatic; however, when pain develops, it’s usually severe and persistent and may coexist with impaired movement resulting from impingement of abnormal bone on the spinal cord or sensory nerve root. Such pain intensifies with weight bearing.
The patient with skull involvement shows characteristic cranial enlargement over frontal and occipital areas (hat size may increase) and may complain of headaches. Other deformities include kyphosis (spinal curvature due to compression fractures of vertebrae), accompanied by a barrel-shaped chest and asymmetrical bowing of the tibia and femur, which can reduce height. Pagetic sites are warm and tender and are susceptible to pathologic fractures after minor trauma. Pagetic fractures heal slowly, and for many patients they never completely heal.
Bony impingement on the cranial nerves may cause blindness and hearing loss with tinnitus and vertigo. Other complications include hypertension, renal calculi, hypercalcemia, gout, heart failure, and a waddling gait (from softening of pelvic bones).
Source: Handbook of Diseases, 2003
When considering symptoms of Paget's disease of bone, it is also important to consider Paget's disease of bone as a possible cause of other medical conditions. The Disease Database lists the following medical conditions that Paget's disease of bone may cause:
Onset of Paget's disease of bone: usually 50-70 years of age
These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:
Full list of premium articles on symptoms and diagnosis
The symptom information on this page attempts to provide a list of some possible signs and symptoms of Paget's disease of bone. This signs and symptoms information for Paget's disease of bone has been gathered from various sources, may not be fully accurate, and may not be the full list of Paget's disease of bone signs or Paget's disease of bone symptoms. Furthermore, signs and symptoms of Paget's disease of bone may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Paget's disease of bone symptoms.
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