Inheritance and Genetics of Pancreatic cancer

Racial Patterns for Pancreatic cancer:

Racial Details for Pancreatic cancer: African Americans are more likely than Asians, Hispanics, or whites to get pancreatic cancer. (Source: excerpt from What You Need To Know About Cancer of the Pancreas: NCI)

Pancreatic cancer: Genetics Information

Genetics of Pancreatic cancer: About 90% of human pancreatic carcinomas show a loss of part of chromosome 18. In 1996, a possible tumor suppressor gene, DPC4 (Smad4), was discovered from the section that is lost in pancreatic cancer, so may play a role in pancreatic cancer. There is a whole family of Smad proteins in vertebrates, all involved in signal transduction of transforming growth factor b (TGFb) related pathways. Other tumor suppressor genes include p53 and Rb, which, if mutated or absent from the genome can contribute to cancerous growth in a variety of tissues. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Pancreatic cancer refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

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