Inheritance and Genetics of Pendred syndrome

Pendred syndrome: Genetics Information

Genetics of Pendred syndrome: In December of 1997, scientists at NIH's National Human Genome Research Institute used the physical map of human chromosome 7 to help identify an altered gene, PDS, thought to cause pendred syndrome. The normal gene makes a protein, called pendrin, that is found at significant levels only in the thyroid and is closely related to a number of sulfate transporters. When the gene for this protein is mutated, the person carrying it will exhibit the symptoms of Pendred syndrome. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Pendred syndrome refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

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