As with all medical conditions, there may be many causal factors. Further relevant information on causes of Perimenopause may be found in:
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❑ Physiologic menopause, the normal decline in ovarian function due to aging, begins in most women between ages 45 and 55, on average 51, and results in infrequent ovulation, decreased menstrual function and, eventually, cessation of menstruation.
❑ Pathologic (premature) menopause, the gradual or abrupt cessation of menstruation before age 40, occurs idiopathically in about 5% of women in the United States. However, certain diseases, especially severe infections and reproductive tract tumors, may cause pathologic menopause by seriously impairing ovarian function. Other factors that may precipitate pathologic menopause include malnutrition, debilitation, extreme emotional stress, excessive radiation exposure, and surgical procedures that impair ovarian blood supply.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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