Causes of Peripheral neuropathy

List of causes of Peripheral neuropathy

Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Peripheral neuropathy) that could possibly cause Peripheral neuropathy includes:

• Diabetic peripheral neuropathy - diabetes is a very common cause
• Charcot-Marie-Tooth syndrome - a genetic syndrome causing peripheral neuropathy
• Uremia
• AIDs
• Nutritional deficiencies
• Nerve entrapment
• Nerve compression (see Nerve symptoms)
• Carpal tunnel syndrome
• Trauma
• Penetrating injuries
• Contusions
• Fractures
• Dislocated bones
• Prolonged use of crutches
• Staying in one position for too long
• Tumor
• Intraneural hemorrhage
• Cold exposure
• Radiation exposure
• Certain medicines
• Certain toxic substances
• Atherosclerosis
• Systemic lupus erythematosus
• Scleroderma
• Sarcoidosis
• Rheumatoid arthritis
• Polyarteritis nodosa

More causes: see full list of causes for Peripheral neuropathy

Causes of Peripheral neuropathy (Diseases Database):

The follow list shows some of the possible medical causes of Peripheral neuropathy that are listed by the Diseases Database:

• Oxaliplatin
• Ataxia telangiectasia
• Vincristine
• Neurilemmoma
• Chronic idiopathic axonal polyneuropathy
• Legionella pneumophila
• Klumpke paralysis
• Carpal tunnel syndrome
• Benign symmetrical lipomatosis of Madelung
• Ethambutol
• Familial alphalipoprotein deficiency
• Mercury
• Paraneoplastic syndrome
• Mitochondrial trifunctional protein deficiency
• Neurofibromatosis type 1
• Arylsulphatase A deficiency
• Amphotericin B
• Pernicious anaemia
• Fracture of bone
• POEMS syndrome
• Vitamin B6 deficiency
• Benign monoclonal gammopathy
• Arsenicals
• Refsum's disease
• Amyloid polyneuropathy (Portuguese)
• Parvovirus B19 infection
• Spondylosis
• Porphobilinogen synthase deficiency
• Hereditary sensory and autonomic neuropathy type 4
• Trigeminal causalgia
• Alpha-methylacyl-CoA racemase deficiency
• Systemic sclerosis
• Zalcitabine
• Pituitary tumour (growth hormone secreting)
• Hypophosphataemia
• Shy-Drager syndrome
• Renal failure, chronic
• Melarsoprol
• Malabsorption syndrome
• Mycoplasma pneumoniae
• Disulfiram
• Gold salts
• Thalidomide
• Paget's disease of bone
• Cholestanol storage disease
• Polyradiculoneuropathy, chronic inflammatory
• Clioquinol
• Superior orbital fissure syndrome
• Paclitaxel
• Isoniazid
• Arsenic trioxide
• Diabetes mellitus type 1
• Cockayne syndrome
• Vasculitis
• McLeod neuroacanthocytosis syndrome
• Myeloma
• Altretamine
• Hereditary sensorimotor neuropathy type 2
• Thiamine (Vitamin B1) deficiency
• Vitamin B12 deficiency
• Metronidazole
• Acute disseminated encephalomyelitis
• Haemochromatosis
• Lamivudine
• Compartment syndrome
• Didanosine
• Hereditary sensorimotor neuropathy type 3
• Colchicine
• Mixed essential cryoglobulinaemia
• Amiodarone
• Neurofibromatosis type 2
• MELAS
• Cisplatin
• Non-Hodgkin's lymphoma
• Stavudine
• Bortezomib
• Infraorbital nerve dehiscence
• Nitrofurantoin

Causes of Peripheral neuropathy: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Peripheral neuropathy.

Peripheral Edema: Differential Diagnosis
(In a Page: Signs and Symptoms)

• Venous insufficiency
  –Caused by incompetent venous valves
  –Skin characteristically has superficial varicose veins associated with a reddish-brown pretibial discoloration (“venous stasis skin changes”)
  –Swelling is typically worse after legs are held in a dependent position and is least noticeable after a night's sleep
• Congestive heart failure
  –Associated with pitting peripheral edema
  –Other signs of heart failure include a third heart sound, cardiomegaly, and hepatomegaly
• Cellulitis
  –Usually unilateral
  –Edematous legs are typically red, warm, and inflamed
  –The patient may exhibit signs of systemic toxicity with fever and leukocytosis
  • Deep venous thrombosis
    –Typically unilateral swelling
    –May exhibit a palpable cord representing a thrombosed vein
    –Homan's sign (pain in the calf with passive dorsiflexion of the foot)
    –Virchow's triad (hypercoagulable states, venous stasis, and vessel injury) are risk factors
  • Cirrhosis
    –Advanced liver disease results in hypoalbuminemia and poor venous return through cirrhotic liver tissue
    –Other stigmata of chronic liver disease include caput medusae, ascites, and spider angiomata
  • Nephrotic syndrome
    –Glomerular damage results in protein loss and decreased oncotic pressure
  • Less common etiologies (“zebras”) include filariasis (lymphatic infection by Wuchereria bancrofti worm), myxedema (seen in patients with severe hypothyroidism), Milroy's disease (congenital lymphedema), chronic lymphedema (e.g., lymphatic damage due to surgery, such as vein harvesting for CABG), and gout

READ BOOK EXCERPT ONLINE »

Peripheral Neuropathy: Differential Overview
(Field Guide to Bedside Diagnosis)

❑ Diabetes

❑ Alcohol

❑ Vitamin B₁₂ deficiency

❑ Drugs

❑ Carcinomatous

❑ Lead

❑ Guillain-Barré

❑ Tabes dorsalis

❑ Syringomyelia

❑ Polyarteritis nodosa

❑ Amyloidosis

❑ Polymyositis

❑ Pellagra

❑ Arsenic

❑ Porphyria

❑ Wallenberg syndrome

❑ Thalamic lesion

❑ Brown-Sequard syndrome

READ BOOK EXCERPT ONLINE »

Peripheral neuropathy as a complication of other conditions:

Other conditions that might have Peripheral neuropathy as a complication may, potentially, be an underlying cause of Peripheral neuropathy. Our database lists the following as having Peripheral neuropathy as a complication of that condition:

• Alcoholism
• Chronic Inflammatory Demyelinating Polyneuropathy
• Diabetes
• Diabetic neuropathy
• Diabetic Peripheral Neuropathy
• Lupus
• Pinched Nerve
• Polyarteritis nodosa
• Porphyria
• Sjogren's Syndrome
• Type 1 diabetes
• Type 2 diabetes

Peripheral neuropathy as a symptom:

Conditions listing Peripheral neuropathy as a symptom may also be potential underlying causes of Peripheral neuropathy. Our database lists the following as having Peripheral neuropathy as a symptom of that condition:

• AIDS-Related Opportunistic Infections
• Alcohol-induced pseudo-Cushing syndrome
• Amyloidosis
• Angiofollicular lymph hyperplasia
• Autoimmune Diseases of the Nervous System
• Celiac disease, susceptibility to 1
• Celiac disease, susceptibility to 10
• Celiac disease, susceptibility to 11
• Celiac disease, susceptibility to 12
• Celiac disease, susceptibility to 13
• Celiac disease, susceptibility to 2
• Celiac disease, susceptibility to 3
• Celiac disease, susceptibility to 4
• Celiac disease, susceptibility to 5
• Celiac disease, susceptibility to 6
• Celiac disease, susceptibility to 7
• Celiac disease, susceptibility to 8
• Celiac disease, susceptibility to 9
• Cerebrotendinous Xanthomatosus
• Cervical hypertrichosis - peripheral neuropathy
• Cervical hypertrichosis neuropathy
• Charcot-Marie-Tooth disease with ptosis and parkinsonism
• Churg-Strauss Syndrome
• Cockayne syndrome
• Congenital disorder of glycosylation type 1A
• De Sanctis-Cacchione syndrome
• Deafness peripheral - neuropathy - arterial disease
• Desmin related myopathy
• Diabetes
• Diabetic neuropathy
• Hepatorenal tyrosinemia
• Hypobetalipoproteinaemia - ataxia - hearing loss
• Hypomyelination - congenital cataract
• Hypomyelination and congenital cataract
• Idiopathic hypereosinophilic syndrome
• Immunoglobulinic amyloidosis
• Inclusion Body Myositis
• Lead poisoning
• Lupus
• Metabolic Syndrome
• Microscopic Polyangiitis
• Mitochondrial neurogastrointestinal encephalopathy syndrome
• Mitochondrial trifunctional protein deficiency
• Neuropathy, distal hereditary motor, type VIIA
• Polyradiculoneuropathy
• Refsum Disease
• Refsum disease with increased pipecolic acidemia
• Rosenberg-Chutorian Syndrome
• Selenium - overuse
• Spastic paraplegia 23
• Spastic paraplegia 30, autosomal recessive
• Spinocerebellar ataxia, Machado-Joseph type III
• Subacute myelo-optico neuropathy syndrome
• Toluene sniffing syndrome
• Type 2 diabetes
• Tyrosinemia
• Vitamin B6 - adverse effects
• Waldenström Macroglobulinemia

Medications or substances causing Peripheral neuropathy:

The following drugs, medications, substances or toxins are some of the possible causes of Peripheral neuropathy as a symptom. This list is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

• Dapsone
• Avlosulfon
• Cytarabine Hydrochloride
• Cytosar-U
• Chloramphenicol

See full list of 28 medications causing Peripheral neuropathy

Drug interactions causing Peripheral neuropathy:

When combined, certain drugs, medications, substances or toxins may react causing Peripheral neuropathy as a symptom.

The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

• Stavudine and hydroxyurea interaction
• Zerit and hydroxyurea interaction
• Zerit XR and hydroxyurea interaction
• Stavudine and didanosine interaction
• Zerit and didanosine interaction

See full list of 44 drug interactions causing Peripheral neuropathy

Medical news summaries relating to Peripheral neuropathy:

The following medical news items are relevant to causes of Peripheral neuropathy:

• Diabetes: the simple facts
• Diabetic neuropathy causal link
• Diuretics and diabetes

Cause statistics for Peripheral neuropathy:

The following are statistics from various sources about the causes of Peripheral neuropathy:

• 26% of diabetic adults attending specialist diabetes services had peripheral neuropathy in Australia 2002 (NADC, 2003, Australia’s Health 2004, AIHW)

Related information on causes of Peripheral neuropathy:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Peripheral neuropathy may be found in:

• Risk factors for Peripheral neuropathy
• Medications that may cause Peripheral neuropathy
• Hidden causes of Peripheral neuropathy