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Diseases » Plague » Causes
 

Causes of Plague

Plague Causes: Book Excerpts

Plague as a symptom:

Conditions listing Plague as a symptom may also be potential underlying causes of Plague. Our database lists the following as having Plague as a symptom of that condition:

What causes Plague?

Causes: Plague: Yersinia pestis bacteria

CDC Plague Home Page: DVBID (Excerpt)

People usually get plague from being bitten by a rodent flea that is carrying the plague bacterium or by handling an infected animal. (Source: excerpt from CDC Plague Home Page: DVBID)

Facts About Plague: CDC-OC (Excerpt)

Plague is caused by Yersinia pestis bacillus. (Source: excerpt from Facts About Plague: CDC-OC)

Related information on causes of Plague:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Plague may be found in:

Causes of Plague: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Plague.

Plague: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

Plague is usually transmitted to humans through the bite of a flea from an infected rodent host, such as a rat, squirrel, prairie dog, or hare. (See Carrier of bubonic plague.) Occasionally, transmission occurs from handling infected animals or their tissues. Bubonic plague is notorious for the historic pandemics in Europe and Asia during the Middle Ages, which in some areas killed up to two-thirds of the population. This form is rarely transmitted from person to person. However, the untreated bubonic form may progress to a secondary pneumonic form, which is transmitted by contaminated respiratory droplets (coughing) and is highly contagious. In the United States, the primary pneumonic form usually occurs after inhalation of Y. pestis in a laboratory.

Sylvatic (wild rodent) plague remains endemic in South America, the Near East, central and Southeast Asia, north central and southern Africa, Mexico, and western United States and Canada. In the United States, its incidence has been rising, a possible reflection of different bacterial strains or environmental changes that favor rodent growth in certain areas. Plague tends to occur between May and September; between October and February it usually occurs in hunters who skin wild animals. One attack confers permanent immunity.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Plague: Causes
(Handbook of Diseases)

The bite of a flea from an infected rodent host — such as a rat, squirrel, prairie dog, or hare — is the typical transmission route to humans. Occasionally, transmission occurs from handling infected animals or their tissues. Bubonic plague is notorious for the historic pandemics in Europe and Asia during the Middle Ages, which in some areas killed up to two-thirds of the population. This form is rarely transmitted from person to person. However, the untreated bubonic form may progress to a highly contagious, secondary pneumonic form, which is transmitted by contaminated respiratory droplets. In the United States, the primary pneumonic form usually occurs after inhalation of Y. pestis in a laboratory.

Endemic areas in the United States are California, Utah, Arizona, Nevada, and New Mexico. Bubonic and pneumonic plague can occur.

» READ BOOK EXCERPT ONLINE »

Source: Handbook of Diseases, 2003

Plague: Plague - pathophysiology
(The 5-Minute Pediatric Consult)

  • Dermatologic portal of entry:
    • Yersinia pestis is most commonly transmitted from fleas to humans via the regurgitation of the organism into the bite during the flea’s blood meal (into a foregut already obstructed with plague organisms). Rodents, dogs, cats, and rabbits can thereby act as reservoirs of infection (by harboring infected fleas). Alternatively, direct skin inoculation of organisms from infected animal tissue or blood can occur through breaks in the skin typically occuring when hunters are skinning quarry.
    • Lymphatic spread of infection to the regional lymph nodes creates a localized inflammatory response (bubo).
    • Subsequent hematogenous spread of the organism to other organs results in the production of greater levels of bacterial endotoxin (septicemic plague).
    • Both the bubonic and septicemic presentations of plague can progress to pneumonic plague if untreated.
  • Respiratory portal of entry:
    • Pneumonic plague: Acquired via contact with the saliva or respiratory droplets (either from a human or more commonly in the US, from a cat with plague pneumonia)
  • Incubation period:
    • Usually 2–6 days between exposure and 1st presentation of symptoms, but this period can be shorter for pneumonic plague.

Plague - etiology

The illness commonly known as the plague is caused by Y. pestis, a Gram-negative pleomorphic bacillus that is part of the Enterobacteriaceae family.

» READ BOOK EXCERPT ONLINE »

Source: The 5-Minute Pediatric Consult, 2008


 » Next page: Risk Factors for Plague

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