Cure Research for Preeclampsia
Cure Research discussion for Preeclampsia:
REPORT of the WORKING GROUP on RESEARCH on HYPERTENSION DURING PREGNANCY: NHLBI (Excerpt)
Furthermore, a
small trial of antioxidant therapy (1,000 mg vitamin C and 400 IU of vitamin E)
resulted in a reduced incidence of preeclampsia when begun at 22 weeks gestation
in women at high risk for the syndrome. Thus, the closest thing to a treatment
target in the field is anti-oxidant therapy based on this collection of
hypotheses and data. However, effectiveness in large populations and, even more
importantly, safety for the fetus, are not established.
(Source: excerpt from REPORT of the WORKING GROUP on RESEARCH on HYPERTENSION DURING PREGNANCY: NHLBI)
REPORT of the WORKING GROUP on RESEARCH on HYPERTENSION DURING PREGNANCY: NHLBI (Excerpt)
Treatment and
prevention trials have been disappointing to date. However, several recent
studies have suggested causal links between oxidative stress, depletion of
vitamin C, low levels of the endogenous vasodilator nitric oxide, and the
development of preeclampsia, suggest that there may be a role for anti-oxidant
vitamins in the prevention of preeclampsia. A clinical trial should be
undertaken testing the hypothesis that anti-oxidant vitamins can reduce the risk
of preeclampsia, reduce maternal and fetal mortality, and increase
birthweight. Such a trial, and all other clinical trials, also should
incorporate study of biomarkers and other measures of risk factors and determine
predictors and early pathophysiological changes of preeclampsia in low-risk and
high-risk populations. A protocol for a similar trial has been developed in the
National Institute of Child Health and Human Development's (NICHD)
Maternal-Fetal Medicine Units Network and the possibility of a collaborative
arrangement of the NHLBI with NICHD in conducting such a trial should be
explored. It might be effective to utilize this same resource for a study for
the treatment of preexisting hypertension in pregnancy.
(Source: excerpt from REPORT of the WORKING GROUP on RESEARCH on HYPERTENSION DURING PREGNANCY: NHLBI)
Medical research for Preeclampsia: medical news summaries:
The following medical news items
are relevant to medical research for Preeclampsia:
Clinical trials for Preeclampsia
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