Clinical Trials for Preeclampsia
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Preeclampsia is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Preeclampsia:
- Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - labetalol (seizure prevention),MgSO4 (seizure prevention)
- The Relaxation and Blood Pressure in Pregnancy (REBIP) Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Calcium for Pre-Eclampsia Prevention (CPEP) - This study has been completed (Current: 23 Nov 2006) - calcium
- Oral Calcium in Pregnant Women With Hypertension - This study has been completed (Current: 23 Nov 2006) - calcium
- Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia - This study has been completed (Current: 23 Nov 2006) - magnesium sulfate,nimodipine
- Regulation of Placental Vascular Reactivity in Pregnancy-Induced Hypertension - This study has been completed (Current: 23 Nov 2006)
- Renin and Prorenin in Pregnancy - This study has been completed (Current: 23 Nov 2006)
- Angiotensinogen Variants and Adverse Pregnancy Outcomes - This study has been completed (Current: 23 Nov 2006)
- Hypertensive and Normal Pregnancy--Calcium Metabolism and Renin-Angiotensin - SCOR in Hypertension - This study has been completed (Current: 23 Nov 2006)
- Antioxidant Therapy to Prevent Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Vitamin C and E
- Cardiovascular and Autonomic Reactivity in Women With a History of Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - alpha methyldopa
- Prevention of Pre-Term Birth by Treatment of Periodontal Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Vitamins C and E or placebo
- Sildenafil Citrate for the Treatment of Established Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- the Implications of Pathogenesis of Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- L-Arginine in Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - L-arginine
- Efficacy Study of Digibind for Treatment of Severe Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Anti-digoxin antibody (FAB fragment)
- Disease Modification in Toxaemia of Pregnancy. - This study is currently recruiting patients (Current: 23 Nov 2006) - Recombinant human activated protein C or drotrecogin alpha
- Hypertonic Saline Use in Preeclampsia - This study has been completed (Current: 23 Nov 2006) - 2% buffered hypertonic saline administration
- CHIPS (Control of Hypertension in Pregnancy Study): A Pilot Trial - This study has been completed (Current: 23 Nov 2006)
- ECLAXIR:Search for an Association Between CX3CR1 V249I Polymorphism, Preeclampsia and Endothelial Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006) - methyldopa,labetalol,nifedipine,clonidine
- Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction - This study is currently recruiting patients (Current: 23 Nov 2006) - Epidural ropivacaine
- Hemodynamic Measurements in Women With Serious Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Endothelial and Left Ventricular Function in Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Prospective Study in Pregnant Women With Hypercoagulopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Prevalence Study of Sleep Apnea in Women With Preeclampsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- LMWH to Prevent Preeclampsia and Fetal Growth Restriction - This study has been terminated (Current: 23 Nov 2006) - Dalteparin
- Glomerular Injury of Preeclampsia - This study has been completed (Current: 23 Nov 2006) - L-Arginine Supplementation
- Coenzyme Q10 Supplementation and Development of Preeclampsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Coenzyme Q10
- Evaluation of the Safety of Relaxin in Severe Preeclampsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - recombinant human relaxin
- Mechanism of Thrombocytopenia in Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
- Leptin and Cytokines in Diabetic Pregnancy - Physiologic or Pathogenic Role - This study is currently recruiting patients (Current: 23 Nov 2006)
- Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia - This study has been completed (Current: 23 Nov 2006) - abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
- Family Study on Preeclampsia - This study has been completed (Current: 23 Nov 2006)
- Antioxidant Supplementation in Pregnant Women With Low Antioxidant Status - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Vitamin C 1000mg and E 400IU
- Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - labetalol (seizure prevention),MgSO4 (seizure prevention)
- Calcium for Pre-Eclampsia Prevention (CPEP) - This study has been completed (Current: 23 Nov 2006) - calcium
- Oral Calcium in Pregnant Women With Hypertension - This study has been completed (Current: 23 Nov 2006) - calcium
- Renin and Prorenin in Pregnancy - This study has been completed (Current: 23 Nov 2006)
- Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia - This study has been completed (Current: 23 Nov 2006) - magnesium sulfate,nimodipine
- Prevention of Pre-Term Birth by Treatment of Periodontal Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Efficacy Study of Digibind for Treatment of Severe Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Anti-digoxin antibody (FAB fragment)
- Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction - This study is currently recruiting patients (Current: 23 Nov 2006) - Epidural ropivacaine
- Prospective Study in Pregnant Women With Hypercoagulopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Glomerular Injury of Preeclampsia - This study has been completed (Current: 23 Nov 2006) - L-Arginine Supplementation
- The Relaxation and Blood Pressure in Pregnancy (REBIP) Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Evaluation of the Safety of Relaxin in Severe Preeclampsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - recombinant human relaxin
- Antioxidant Therapy to Prevent Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Vitamin C and E
- Cardiovascular and Autonomic Reactivity in Women With a History of Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - alpha methyldopa
- Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Vitamins C and E or placebo
- Prevalence Study of Sleep Apnea in Women With Preeclampsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- LMWH to Prevent Preeclampsia and Fetal Growth Restriction - This study has been terminated (Current: 23 Nov 2006) - Dalteparin
- Mechanism of Thrombocytopenia in Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
- Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia - This study has been completed (Current: 23 Nov 2006) - abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
- Family Study on Preeclampsia - This study has been completed (Current: 23 Nov 2006)
- Antioxidant Supplementation in Pregnant Women With Low Antioxidant Status - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Vitamin C 1000mg and E 400IU
- Hypertonic Saline Use in Preeclampsia - This study has been completed (Current: 23 Nov 2006) - 2% buffered hypertonic saline administration
- Angiotensinogen Variants and Adverse Pregnancy Outcomes - This study has been completed (Current: 23 Nov 2006)
- Hypertensive and Normal Pregnancy--Calcium Metabolism and Renin-Angiotensin - SCOR in Hypertension - This study has been completed (Current: 23 Nov 2006)
- Sildenafil Citrate for the Treatment of Established Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- L-Arginine in Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006) - L-arginine
- Disease Modification in Toxaemia of Pregnancy. - This study is currently recruiting patients (Current: 23 Nov 2006) - Recombinant human activated protein C or drotrecogin alpha
- Endothelial and Left Ventricular Function in Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- the Implications of Pathogenesis of Pre-Eclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- ECLAXIR:Search for an Association Between CX3CR1 V249I Polymorphism, Preeclampsia and Endothelial Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
- Hemodynamic Measurements in Women With Serious Preeclampsia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Coenzyme Q10 Supplementation and Development of Preeclampsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Coenzyme Q10
- Leptin and Cytokines in Diabetic Pregnancy - Physiologic or Pathogenic Role - This study is currently recruiting patients (Current: 23 Nov 2006)
- Regulation of Placental Vascular Reactivity in Pregnancy-Induced Hypertension - This study has been completed (Current: 23 Nov 2006)
- Treatment Targets for Chronic Hypertension in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006) - methyldopa,labetalol,nifedipine,clonidine
- Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence. - This study is currently recruiting patients (Current: 23 Nov 2006)
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Preeclampsia:
The trial data on this page has been sourced from
Rate This Website
What do you think about the features of this website?
Take our user survey and have your say:
Website User Survey
Medical Tools & Articles:
Tools & Services:
Medical Articles:
Forums & Message Boards
- Ask or answer a question at the Boards:
