Drug Causes of Primary pulmonary hypertension

Medication causes list:

The list of possible medications or substances mentioned in sources as possibe causes of Primary pulmonary hypertension includes:

• Aminorex fumarate
• Dexfenfluramine
• Fenfluramine

Medication causes:

Prescription Medications for the Treatment of Obesity: NIDDK (Excerpt)

Primary pulmonary hypertension (PPH) is a rare but potentially fatal disorder that affects the blood vessels in the lungs and results in death within 4 years in 45 percent of its victims. It should be noted that the vast majority of cases of PPH have occurred in patients who were taking fenfluramine or dexfenfluramine, either alone or in combination. There have been only a few case reports of PPH in patients taking phentermine alone, although the possibility that phentermine alone may be associated with PPH cannot be ruled out. No cases of PPH have been reported with sibutramine, but because of the low incidence of this disease in the underlying population, it is not known whether or not sibutramine may cause this disease. (Source: excerpt from Prescription Medications for the Treatment of Obesity: NIDDK)

NHLBI, Facts About Primary Pulmonary Hypertension: NHLBI (Excerpt)

Between 1967 and 1973, a 10-fold increase in unexplained pulmonary hypertension was reported in central Europe. The rise was subsequently traced to aminorex fumarate, an amphetamine-like drug introduced in Europe in 1965 to control appetite. Only about 1 in 1,000 people who took the drug developed PPH. When they stopped taking the drug, some improved considerably; in others, the disease kept getting worse. Once aminorex was removed from the market, the incidence of PPH went down to normal levels.

More recently, in the United States and France, several cases of PPH have been associated with the appetite suppressants, fenfluramine and dexfenfluramine. (Source: excerpt from NHLBI, Facts About Primary Pulmonary Hypertension: NHLBI)

About medication causes:

Another misdiagnosis possibility is that a particular medication or substance may be the real cause of the disease. Certain medications, chemicals, toxins or substances may possibly be underlying causes of Primary pulmonary hypertension. Side effects of medications, or exposure to toxins, chemicals, or other substances may cause a symptom or condition. Hence, they become possible underlying causes of Primary pulmonary hypertension but are often misdiagnosed or overlooked as a cause. For a general overview of this misdiagnosis issue, see Medication Underlying Cause Misdiagnosis.

 » Next page: Associated Conditions of Primary pulmonary hypertension

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• Associated Conditions of Primary pulmonary hypertension
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