What is Protein S deficiency?

What is Protein S deficiency?

• Protein S deficiency: A genetic condition where a person faces an increased risk of blood clot formation. It is characterized by a deficiency of functioning protein S which is a protein needed to regulate the blood clotting process. The homozygous form of the condition carries a much higher risk of thrombosis with severe thrombosis often occurring at birth.
• Protein S deficiency: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
  Source - Diseases Database

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Protein S deficiency as a "rare disease".
Source - Orphanet

Protein S deficiency: Introduction

How serious is Protein S deficiency?

Complications of Protein S deficiency: see complications of Protein S deficiency

What are the symptoms of Protein S deficiency?

Symptoms of Protein S deficiency: see symptoms of Protein S deficiency

Complications of Protein S deficiency: see complications of Protein S deficiency

Protein S deficiency: Testing

Misdiagnosis: see misdiagnosis and Protein S deficiency.

How is it treated?

Treatments for Protein S deficiency: see treatments for Protein S deficiency
Research for Protein S deficiency: see research for Protein S deficiency

Name of Protein S deficiency

Main name of condition: Protein S deficiency

Research the causes of these diseases that are similar to, or related to, Protein S deficiency:

• Venous thrombosis
• Disseminated intravascular coagulation
• Deep venous thrombosis
• Thrombophilia

 » Next page: Prevalence and Incidence of Protein S deficiency

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