Diseases » Protein S deficiency » Introduction

Protein S deficiency

Protein S deficiency: Introduction

Protein S deficiency: A genetic condition where a person faces an increased risk of blood clot formation. It is characterized by a deficiency of functioning protein S which is a protein needed to regulate the blood clotting process. The homozygous form of the condition carries a much higher risk of thrombosis with severe thrombosis often occurring at birth. More detailed information about the symptoms, causes, and treatments of Protein S deficiency is available below.

Symptoms of Protein S deficiency

• Thrombosis
• Deep vein thrombosis
• Pulmonary embolism
• Purpura fulminans
• more symptoms...»

Read more about symptoms of Protein S deficiency

Protein S deficiency: Complications

Review possible medical complications related to Protein S deficiency:

• Cerebral vein thrombosis
• Mesenteric vein thrombosis
• Postphlebitic syndrome
• Death due to blood clots
• more complications...»

Disease Topics Related To Protein S deficiency

Research the causes of these diseases that are similar to, or related to, Protein S deficiency:

• Venous thrombosis
• Disseminated intravascular coagulation
• Deep venous thrombosis
• Thrombophilia
• more related diseases...»

Wrongly Diagnosed with Protein S deficiency?

• Misdiagnosis of Protein S deficiency
• Failure to diagnose Protein S deficiency
• Undiagnosed: Protein S deficiency

Misdiagnosis and Protein S deficiency

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms of multiple sclerosis). See symptoms of Vitamin B12 deficiency or misdiagnosis of multiple sclerosis....read more »

Read more about Misdiagnosis and Protein S deficiency

Evidence Based Medicine Research for Protein S deficiency

Medical research articles related to Protein S deficiency include:

• For a woman using a 3rd generation combined oral contraceptive for the treatment of breakthrough bleeding whilst using the progestogen-only implant is she at a higher risk of developing venous thromboembolism than is she were to use a 2nd generation combi
• Diagnosis, evaluation and management of the hypertensive disorders of pregnancy
• Second Trimester Pregnancy Loss
• For women with Factor V Leiden and a history deep vein thrombosis, and now using permanent warfarin therapy, can the levonorgestrel-releasing intrauterine system be used safely?
• Thromboembolic disease in pregnancy and the puerperium : acute management
• more research...»

Click here to find more evidence-based articles on the TRIP Database

Videos for Protein S deficiency

See full list of 4 related videos

Reseach about Protein S deficiency

Visit our research pages for current research about Protein S deficiency treatments.

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Definitions of Protein S deficiency:

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523) - (Source - Diseases Database)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Protein S deficiency as a "rare disease".
Source - Orphanet

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